Increased Nitric Oxide Production and GFAP Expression in the Brains of Influenza A/NWS Virus Infected Mice

The cause of influenza to the brain was investigated using the A/NWS/33 influenza virus infected BALB/c mouse model. NOS-2 mRNA levels in the infected mouse brain was greater than in control mice in all brain regions examined, particularly in the olfactory bulb and hippocampus by 1 day p.i. On the contrary, no differences in NOS-1 or NOS-3 mRNA levels were found between infected and control mice. There was also a marked increase in the levels of metabolites of nitric oxide in the olfactory bulb and hippocampus. Immunohistochemistry showed positive staining for anti-NOS-2 primarily in the hippocampus of infected mice. Further, anti-NOS-2 and GFAP staining was mostly found around capillary blood vessels of the hippocampus starting early in the course of the disease. These results indicate that the NWS enhances the activation of astrocytes and NOS-2 expression which in turn enhances NO production and the expansion of capillary blood vessels

Value Functions and Transversality Conditions for Infinite-Horizon Optimal Control Problems

This paper investigates the relationship between the maximum principle with an infinite horizon and dynamic programming and sheds new light upon the role of the transversality condition at infinity as necessary and sufficient conditions for optimality with or without convexity assumptions. We first derive the nonsmooth maximum principle and the adjoint inclusion for the value function as necessary conditions for optimality that exhibit the relationship between the maximum principle and dynamic programming. We then present sufficiency theorems that are consistent with the strengthened maximum principle, employing the adjoint inequalities for the Hamiltonian and the value function. Synthesizing these results, necessary and sufficient conditions for optimality are provided for the convex case. In particular, the role of the transversality conditions at infinity is clarified

Photo-stimulated desorption from water and methane clusters on the surface of solid neon

Photo-stimulated desorption of ions from methane and water heterocluster on the surface of solid neon was studied. The desorption yields of the variety of photo-desorbed species showed strong dependence on the composition and the size of the mother cluster. It was found that the presence of a water molecule in the cluster significantly enhanced, or was almost essential for, the desorption of any species observed. Systematic investigation of the correlation between the cluster size and the desorption yield of each ion has revealed the mother cluster which yields the each desorbed ion