Evidence for a Finite Temperature Insulator

In superconductors the zero-resistance current-flow is protected from dissipation at finite temperatures (T) by virtue of the short-circuit condition maintained by the electrons that remain in the condensed state. The recently suggested finite-T insulator and the "superinsulating" phase are different because any residual mechanism of conduction will eventually become dominant as the finite-T insulator sets-in. If the residual conduction is small it may be possible to observe the transition to these intriguing states. We show that the conductivity of the high magnetic-field insulator terminating superconductivity in amorphous indium-oxide exhibits an abrupt drop, and seem to approach a zero conductance at T<0.04 K. We discuss our results in the light of theories that lead to a finite-T insulator

Frequency selective reflection and transmission at a layer composed of a periodic dielectric

The feasibility of using a periodic dielectric layer, composed of alternating bars having dielectric constants epsilon sub 1 and epsilon sub 2, as a frequency selective subreflector in order to permit feed separation in large aperture reflecting antenna systems was examined. For oblique incidence, it is found that total transmission and total reflection can be obtained at different frequencies for proper choices of epsilon sub 1, epsilon 2, and the geometric parameters. The frequencies of total reflection and transmission can be estimated from wave phenomena occurring in a layer of uniform dielectric constant equal to the average for the periodic layers. About some of the frequencies of total transmission, the bandwidth for 90% transmission is found to be 40%. However, the bandwidth for 90% reflection is always found to be much narrower; the greatest value found being 2.5%

Estimation of genetic parameters for first-lactation test-day milk yield in Holstein Friesian cows fitting random regression models

201

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.

Amyloid-β (Aβ) harbors numerous posttranslational modifications (PTMs) that may affect Alzheimer's disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED structure of an Aβ 20-34 fibril with and without the disease-associated PTM, L-isoaspartate, at position 23 (L-isoAsp23). Both wild-type and L-isoAsp23 protofilaments adopt β-helix-like folds with tightly packed cores, resembling the cores of full-length fibrillar Aβ structures, and both self-associate through two distinct interfaces. One of these is a unique Aβ interface strengthened by the isoaspartyl modification. Powder diffraction patterns suggest a similar structure may be adopted by protofilaments of an analogous segment containing the heritable Iowa mutation, Asp23Asn. Consistent with its early onset phenotype in patients, Asp23Asn accelerates aggregation of Aβ 20-34, as does the L-isoAsp23 modification. These structures suggest that the enhanced amyloidogenicity of the modified Aβ segments may also reduce the concentration required to achieve nucleation and therefore help spur the pathogenesis of AD

Excitation of guided waves in layered structures with negative refraction

We study the electromagnetic beam reflection from layered structures that include the so-called double-negative materials, also called left-handed metamaterials. We predict that such structures can demonstrate a giant lateral Goos-Hanchen shift of the scattered beam accompanied by splitting of the reflected and transmitted beams due to the resonant excitation of surface waves at the interfaces between the conventional and double-negative materials as well as due to excitation of leaky modes in the layered structures. The beam shift can be either positive or negative, depending on the type of the guided waves excited by the incoming beam. We also perform finite-difference time-domain simulations and confirm the major effects predicted analytically.Comment: 13 pqages, 10 figures. Also available at http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-2-48

Structure-based inhibitors of amyloid beta core suggest a common interface with tau.

Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which track with cognitive decline in humans. Here, we report the crystal structure of an Aβ core segment determined by MicroED and in it, note characteristics of both fibrillar and oligomeric structure. Using this structure, we designed peptide-based inhibitors that reduce Aβ aggregation and toxicity of already-aggregated species. Unexpectedly, we also found that these inhibitors reduce the efficiency of Aβ-mediated tau aggregation, and moreover reduce aggregation and self-seeding of tau fibrils. The ability of these inhibitors to interfere with both Aβ and tau seeds suggests these fibrils share a common epitope, and supports the hypothesis that cross-seeding is one mechanism by which amyloid is linked to tau aggregation and could promote cognitive decline

Genetic analysis of milk yield in first-lactation Holstein-Friesian in Ethiopia: A lactation average vs random regression test-day model analysis

201

Solving a "Hard" Problem to Approximate an "Easy" One: Heuristics for Maximum Matchings and Maximum Traveling Salesman Problems

We consider geometric instances of the Maximum Weighted Matching Problem (MWMP) and the Maximum Traveling Salesman Problem (MTSP) with up to 3,000,000 vertices. Making use of a geometric duality relationship between MWMP, MTSP, and the Fermat-Weber-Problem (FWP), we develop a heuristic approach that yields in near-linear time solutions as well as upper bounds. Using various computational tools, we get solutions within considerably less than 1% of the optimum. An interesting feature of our approach is that, even though an FWP is hard to compute in theory and Edmonds' algorithm for maximum weighted matching yields a polynomial solution for the MWMP, the practical behavior is just the opposite, and we can solve the FWP with high accuracy in order to find a good heuristic solution for the MWMP.Comment: 20 pages, 14 figures, Latex, to appear in Journal of Experimental Algorithms, 200