Non-factorizable contribution in nonleptonic weak interactions of K mesons

Two pion decays of K mesons, K_L-K_S mass difference, two photon and the Dalitz decays of K_L are studied systematically by assuming that their amplitude is given by a sum of factorizable and non-factorizable ones. The former is estimated by using a naive factorization while the latter is assumed to be dominated by dynamical contributions of various hadron states.Comment: 23 pages,1 figur

FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour

<p>Abstract</p> <p>Background</p> <p>Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly affects the behaviour of the choroid plexus epithelium (CPe). The purpose of this study was to investigate expression of Fgf2 in rodent and human developing CPe and possible function of Fgf2, using <it>in vitro </it>models. The application of Fgf2 to brain <it>in vivo </it>can affect the whole tissue, making it difficult to assess specific responses of the CPe.</p> <p>Methods</p> <p>Expression of Fgf2 was studied by immunohistochemistry in rodent and human embryonic choroid plexus. Effects of Fgf2 on growth, secretion, aggregation and gene expression was investigated using rodent CPe vesicles, a three-dimensional polarized culture model that closely mimics CPe properties <it>in vivo</it>, and rodent CPe monolayer cultures.</p> <p>Results</p> <p>Fgf2 was present early in development of the choroid plexus both in mouse and human, suggesting the importance of this ligand in Fgf signalling in the developing choroid plexus. Parallel analysis of Fgf2 expression and cell proliferation during CP development suggests that Fgf2 is not involved in CPe proliferation <it>in vivo</it>. Consistent with this observation is the failure of Fgf2 to increase proliferation in the tri-dimensional vesicle culture model. The CPe however, can respond to Fgf2 treatment, as the diameter of CPe vesicles is significantly increased by treatment with this growth factor. We show that this is due to an increase in cell aggregation during vesicle formation rather than increased secretion into the vesicle lumen. Finally, Fgf2 regulates expression of the CPe-associated transcription factors, <it>Foxj1 </it>and <it>E2f5</it>, whereas transthyretin, a marker of secretory activity, is not affected by Fgf2 treatment.</p> <p>Conclusion</p> <p>Fgf2 expression early in the development of both human and rodent choroid plexus, and its ability to modulate behaviour and gene expression in CPe, supports the view that Fgf signalling plays a role in the maintenance of integrity and function of this specialized epithelium, and that this role is conserved between rodents and humans.</p

Newly observed two-body decays of B mesons in a hybrid perspective

In consistency with the b --> c type of (quasi) two body decays, recently observed two body decays of B mesons are studied in a hybrid perspective in which their amplitude is given by a sum of factorizable and non-factorizable ones, and a role of the latter in these decays are discussed.Comment: 7 page

Non-factorizable long distance contributions in color suppressed decays of B mesons

$\bar B \to D\pi$, $D^*\pi$, $J/\psi\bar K$ and $J/\psi\pi$ decays are studied. Their amplitude is given by a sum of factorized and non-factorizable ones. The latter which is estimated by using a hard pion approximation is rather small in color favored $\bar B \to D\pi$ and $D^*\pi$ decays but still can efficiently interfere with the main amplitude given by the factorization. In the color suppressed $\bar B \to J/\psi\bar K$ and $J/\psi\pi$ decays, the non-factorizable contribution is very important. The sum of the factorized and non-factorizable amplitudes can reproduce well the existing experimental data on the branching ratios for the color favored $\bar B \to D\pi$ and $D^*\pi$ and the color suppressed $\bar B \to J/\psi \bar K$ and $J/\psi\pi$ decays by taking reasonable values of unknown parameters involved.Comment: 19 pages, Revte