Can Common Crawl Reliably Track Persistent Identifier (PID) Use Over Time

We report here on the results of two studies using two and four monthly web crawls respectively from the Common Crawl (CC) initiative between 2014 and 2017, whose initial goal was to provide empirical evidence for the changing patterns of use of so-called persistent identifiers. This paper focusses on the tooling needed for dealing with CC data, and the problems we found with it. The first study is based on over $10^{12}$ URIs from over $5 * 10^9$ pages crawled in April 2014 and April 2017, the second study adds a further $3 * 10^9$ pages from the April 2015 and April 2016 crawls. We conclude with suggestions on specific actions needed to enable studies based on CC to give reliable longitudinal information.Comment: 7 pages, 1 figure, submitted to TempWeb201

ECONOMIC SURPLUS AND THE DISTRIBUTIONAL CONSEQUENCES OF DEREGULATING TOBACCO PRODUCTION

Reservations on technical and theoretical grounds in the use of the consumer surplus approach to measure benefits of government programs have often appeared in the literature. Therefore, this paper uses an alternative approach in a case study to estimate the annual economic surplus created in South Carolina from deregulating tobacco production. Impacts of deregulation on cropping patterns and income on representative tobacco farms, and distribution of benefits in the economy are examined. Results of this study indicate that deregulation stimulates the economy and would increase the net value added by $5.8 million in the long run.Agricultural and Food Policy,

Letter from Henry S. Thompson.

Letter concerning position as instructor of modern languages in the Utah Agricultural College

Precision Astrometry of a Sample of Speckle Binaries and Multiples with the Adaptive Optics Facilities at the Hale and Keck II Telescopes

Using the adaptive optics facilities at the 200-in Hale and 10-m Keck II, we observed in the near infrared a sample of 12 binary and multiple stars and one open cluster. We used the near diffraction limited images of these systems to measure the relative separations and position angles between their components. In this paper, we investigate and correct for the influence of the differential chromatic refraction and chip distortions on our relative astrometric measurements. Over one night, we achieve an astrometric precision typically well below 1 miliarcsecond and occasionally as small as 40 microarcseconds. Such a precision is in principle sufficient to astrometrically detect planetary mass objects around the components of nearby binary and multiple stars. Since we have not had sufficiently large data sets for the observed sample of stars to detect planets, we provide the limits to planetary mass objects based on the obtained astrometric precision.Comment: 18 pages, 8 figures, 9 tables, to appear in MNRA

LNK suppresses interferon signaling in melanoma.

LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth and survival in adverse conditions. Forced expression of LNK inhibits signaling by interferon-STAT1 and suppresses interferon (IFN) induced cell cycle arrest and cell apoptosis. In contrast, silencing LNK expression by either shRNA or CRISPR-Cas9 potentiates the killing effect of IFN. The IFN-LNK signaling is tightly regulated by a negative feedback mechanism; melanoma cells exposed to IFN upregulate expression of LNK to prevent overactivation of this signaling pathway. Our study reveals an unappreciated function of LNK in melanoma and highlights the critical role of the IFN-STAT1-LNK signaling axis in this potentially devastating disease. LNK may be further explored as a potential therapeutic target for melanoma immunotherapy

Sexuality and Affection among Elderly German Men and Women in Long-Term Relationships: Results of a Prospective Population-Based Study

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The study was funded by the German Federal Ministry for Families, Senior Citizens, Women and Youth (AZ 314-1722-102/16; AZ 301-1720-295/2), the Ministry for Science, Research and Art Baden-Württemberg, and the University of Rostock (FORUN 989020; 889048)

Measuring and Modelling the Redshift Evolution of Clustering: the Hubble Deep Field North

(abridged) The evolution of galaxy clustering from z=0 to z=4.5 is analyzed using the angular correlation function and the photometric redshift distribution of galaxies brighter than I_{AB}\le 28.5 in the HDF North. The reliability of the photometric redshift estimates is discussed on the basis of the available spectroscopic redshifts, comparing different codes and investigating the effects of photometric errors. The redshift bins in which the clustering properties are measured are then optimized to take into account the uncertainties of the photometric redshifts. The results show that the comoving correlation length has a small decrease in the range 0<z<1 followed by an increase at higher z. We compare these results with the theoretical predictions of a variety of cosmological models belonging to the general class of CDM. The comparison with the expected mass clustering evolution indicates that the observed high-redshift galaxies are biased tracers of the dark matter with an effective bias b strongly increasing with redshift. Assuming an Einstein-de Sitter universe, we obtain b\simeq 2 at z=2 and b\simeq 5 at z=4. A comparison of the clustering amplitudes that we measured at z=3 with those reported for LBG suggests that the clustering depends on the abundance of the objects: more abundant objects are less clustered, as expected in the paradigm of hierarchical galaxy formation. The strong clustering and high bias measured at z=3 are consistent with the expected density of massive haloes predicted for the various cosmologies here considered. At z=4, the strong clustering observed in the HDF requires a significant fraction of massive haloes to be already formed by that epoch. This feature could be a discriminant test for the cosmological parameters if confirmed by future observations.Comment: 23 pages, Latex using MN style, figures enclosed. Version accepted for publication in MNRA

Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?

LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGEmyd mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular dystrophy. Up-regulation of LARGE has previously been proposed as a therapy for the secondary dystroglycanopathies: overexpression in cells compensates for defects in multiple dystroglycanopathy genes. Counterintuitively, LARGE overexpression in an FKRP-deficient mouse exacerbates pathology, suggesting that modulation of α-DG glycosylation requires further investigation. Here we demonstrate that transgenic expression of human LARGE (LARGE-LV5) in the LARGEmyd mouse restores α-DG glycosylation (with marked hyperglycosylation in muscle) and that this corrects both the muscle pathology and brain architecture. By quantitative analyses of LARGE transcripts we also here show that levels of transgenic and endogenous LARGE in the brains of transgenic animals are comparable, but that the transgene is markedly overexpressed in heart and particularly skeletal muscle (20–100 fold over endogenous). Our data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP: in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle. Moreover, correction of LARGEmyd brain pathology with only moderate, near-physiological LARGE expression suggests a generous therapeutic window

Tidal Heating Models for the Radii of the Inflated Transiting Giant Planets WASP-4b, WASP-6b, WASP-12b, and TrES-4

In order to explain the inflated radii of some transiting extrasolar giant planets, we investigate a tidal heating scenario for the inflated planets WASP-4b, WASP-6b, WASP-12b, WASP-15b, and TrES-4. To do so, we assume that they retain a nonzero eccentricity, possibly by dint of continuing interaction with a third body. We calculate the amount of extra heating in the envelope that is then required to fit the radius of each planet, and we explore how this additional power depends on the planetary atmospheric opacity and on the mass of a heavy-element central core. There is a degeneracy between the core mass $M_{\rm core}$ and the heating $\dot{E}_{\rm heating}$. Therefore, in the case of tidal heating, there is for each planet a range of the couple $\{M_{\rm core},e^2/Q'_p\}$ that can lead to the same radius, where $Q'_p$ is the tidal dissipation factor and $e$ is the eccentricity. With this in mind, we also investigate the case of the non-inflated planet HAT-P-12b, which can admit solutions combining a heavy-element core and tidal heating. A substantial improvement of the measured eccentricities of such planetary systems could simplify this degeneracy by linking the two unknown parameters $\{M_{\rm core},Q'_p\}$. Further independent constraints on either of these parameters would, through our calculations, constrain the other.Comment: Accepted in ApJ; 17 pages, 3 figures, 6 tables (emulateapj format); expanded explanatory tex