A retrospective study on Equine Herpes Virus type-1 associated myeloencephalopathy in France (2008-2011)

peer reviewe

Pair Plasmas in the Central Engine of Active Galactic Nuclei

As the most promising model for the X-ray emission from a class of Active Galactic Nuclei (AGNs) represented by radio-quiet quasars and Seyfert nuclei, here we introduce the non-thermal pair cascade model, where soft photons are Comptonized by non-thermal electron-positron pair plasmas produced by (gamma)-rays. After summarizing the simplest model of this kind, the "homogeneous spherical cascade model", our most recent work on the "surface cascade model" is presented, where a geometrical effect is introduced. Many characteristics of this model are qualitatively similar to the homogeneous cascade model. However, an important difference is that (gamma)-ray depletion is much more efficient in the surface cascade, and consequently this model naturally satisfies the severe observational constraint imposed by the (gamma)-ray background radiation

Gelatin microparticles aggregates as three-dimensional scaffolding system in cartilage engineering

A three-dimensional (3D) scaffolding system for chondrocytes culture has been produced by agglomeration of cells and gelatin microparticles with a mild centrifuging process. The diameter of the microparticles, around 10 μ, was selected to be in the order of magnitude of the chondrocytes. No gel was used to stabilize the construct that maintained consistency just because of cell and extracellular matrix (ECM) adhesion to the substrate. In one series of samples the microparticles were charged with transforming growth factor, TGF-β1. The kinetics of growth factor delivery was assessed. The initial delivery was approximately 48 % of the total amount delivered up to day 14. Chondrocytes that had been previously expanded in monolayer culture, and thus dedifferentiated, adopted in this 3D environment a round morphology, both with presence or absence of growth factor delivery, with production of ECM that intermingles with gelatin particles. The pellet was stable from the first day of culture. Cell viability was assessed by MTS assay, showing higher absorption values in the cell/unloaded gelatin microparticle pellets than in cell pellets up to day 7. Nevertheless the absorption drops in the following culture times. On the contrary the cell viability of cell/TGF-β1 loaded gelatin microparticle pellets was constant during the 21 days of culture. The formation of actin stress fibres in the cytoskeleton and type I collagen expression was significantly reduced in both cell/gelatin microparticle pellets (with and without TGF-β1) with respect to cell pellet controls. Total type II collagen and sulphated glycosaminoglycans quantification show an enhancement of the production of ECM when TGF-β1 is delivered, as expected because this growth factor stimulate the chondrocyte proliferation and improve the functionality of the tissue.JLGR acknowledge the support of the Spanish Ministry of Education through project No. MAT2010-21611-C03-01 (including the FEDER financial support). The support of the Instituto de Salud Carlos III (ISCIII) through the CIBER initiative of the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) is also acknowledged

Disruptions, Disruptivity, and Safer Operating Windows in the High-β Spherical Torus NSTX

This paper discusses disruption rates, disruption causes, and disruptivity statistics in the high- βN National Spherical Torus Experiment (NSTX) [M. Ono, et al. Nuclear Fusion 40, 557 (2000)]. While the overall disruption rate is rather high, configurations with high βN , moderate q*, strong boundary shaping, sufficient rotation, and broad pressure and current profiles are found to have the lowest disruptivity; active n=1 control further reduces the disruptivity. The disruptivity increases rapidly for q*<2.7, which is substantially above the ideal MHD current limit. In quiescent conditions, qmin >1.25 is generally acceptable for avoiding the onset of core rotating n=1 kink/tearing modes; when EPM and ELM disturbances are present, the required qmin for avoiding those modes is raised to ~1.5. The current ramp and early flat-top phase of the discharges are prone to n=1 core rotating modes locking to the wall, leading to a disruption. Small changes to the discharge fueling during this phase can often mitigate the rotation damping associated with these modes and eliminate the disruption. The largest stored energy disruptions are those that occur at high current when a plasma current rampdown is initiated incorrectly

Three-dimensional distortions of the tokamak plasma boundary: boundary displacements in the presence of saturated MHD instabilities

The three-dimensional plasma boundary displacement induced by long-lasting core magnetohydrodynamic (MHD) instabilities has been measured in JET, MAST and NSTX. Only saturated instabilities are considered here since transient rapidly growing modes which degrade confinement and act as potential triggers for disruptions bring more fundamental concerns than boundary displacements. The measured displacements are usually small, although in extreme cases in MAST when the rotation braking is strong, a significant global displacement can be observed. The instability most likely to saturate and exist for many energy confinement times whilst distorting the boundary of ITER is the saturated internal kink, or helical core, which can be found in plasmas with a wide region of low magnetic shear such as the hybrid scenario. This mode can lead to non-negligible boundary displacements. Nonetheless, the boundary displacement resultant from core MHD instabilities in ITER is predicted to be less than ±1.5% of the minor radius, well within tolerable limits for heat loads to plasma-facing components

Atypical glandular cells in conventional cervical smears: Incidence and follow-up

BACKGROUND: Atypical glandular cells on cervical smears are often associated with clinically significant uterine lesions. The frequency and accuracy of AGC-NOS (i.e. atypical glandular cells, not otherwise specified) diagnoses, regardless of the gland cell type or the degree of suspicion, and their outcome were investigated. METHODS: From January 1, 1990 to December 31, 1999 a total of 261 patients had an AGC-NOS diagnosis made by conventional cervical Papanicolaou smear interpretation representing 0.05% of all Pap-smears analyzed at the national level. 191 (73.2%) patients had a subsequent histological examination, 8 samples were not representative by origin and were excluded. RESULTS: Out of 183 AGC-NOS diagnosed, 56.3% (103/183) were associated with tissue-proven precancerous and/or cancerous lesions, 44% being of endocervical and 56% of endometrial origin. 75% of all AGC-patients were asymptomatic. 66.7% (6/9) of the patients with subsequent invasive endocervical adenocarcinoma (AC) and 56% (28/50) of those patients with invasive endometrial AC were without clinical symptoms. 3 patients out of 9 with an invasive endocervical AC were 35 years of age or less. 10.1% and 12.3% of all 'new' tissue-proven invasive endocervical or endometrial AC respectively recorded by the national Morphologic Tumour Registry (MTR) were first identified by a cytological AGC-NOS diagnosis. CONCLUSION: Our findings emphasize the importance of the cytological AGC-category even in the absence of a precise origin or cell type specification. 56% of the AGC-diagnoses being associated with significant cancerous or precancerous conditions, a complete and careful evaluation is required

Effect of plasma shaping on performance in the National Spherical Torus Experiment

The National Spherical Torus Experiment (NSTX) has explored the effects of shaping on plasma performance as determined by many diverse topics including the stability of global magnetohydrodynamic (MHD) modes (e.g., ideal external kinks and resistive wall modes), edge localized modes (ELMs), bootstrap current drive, divertor flux expansion, and heat transport. Improved shaping capability has been crucial to achieving Βt ∼40%. Precise plasma shape control has been achieved on NSTX using real-time equilibrium reconstruction. NSTX has simultaneously achieved elongation κ∼2.8 and triangularity δ∼0.8. Ideal MHD theory predicts increased stability at high values of shaping factor S≡ q95 Ip (a Bt), which has been observed at large values of the S∼37 [MA (m·T)] on NSTX. The behavior of ELMs is observed to depend on plasma shape. A description of the ELM regimes attained as shape is varied will be presented. Increased shaping is predicted to increase the bootstrap fraction at fixed Ip. The achievement of strong shaping has enabled operation with 1 s pulses with Ip =1 MA, and for 1.6 s for Ip =700 kA. Analysis of the noninductive current fraction as well as empirical analysis of the achievable plasma pulse length as elongation is varied will be presented. Data are presented showing a reduction in peak divertor heat load due to increasing in flux expansion. © 2006 American Institute of Physics

Progress towards Steady State at Low Aspect Ratio on the National Spherical Torus Experiment (NSTX)

Modifications to the plasma control capabilities and poloidal field coils of the National Spherical Torus Experiment (NSTX) have enabled a significant enhancement in shaping capability which has led to the transient achievement of a record shape factor (S ≡ q95 (Iρ⁄ αΒτ)) of ∼41 (MA m−1 Τ−1) simultaneous with a record plasma elongation of κ ≡ β ⁄ α ∼ 3. This result was obtained using isoflux control and real-time equilibrium reconstruction. Achieving high shape factor together with tolerable divertor loading is an important result for future ST burning plasma experiments as exemplified by studies for future ST reactor concepts, as well as neutron producing devices, which rely on achieving high shape factors in order to achieve steady state operation while maintaining MHD stability. Statistical evidence is presented which demonstrates the expected correlation between increased shaping and improved plasma performance

Observation of a High Performance Operating Regime with Small Edge-Localized Modes in the National Spherical Torus Experiment

We report observation of a high performance scenario in the National Spherical Torus Experiment with very small edge-localized modes (ELMs). These ELMs have no measurable impact on stored energy and are consistent with high bootstrap current operation with line average density approaching Greenwald scaling. The ELM perturbation is observed to typically originate near the lower divertor region, as opposed to the outer midplane for ELMs described in the literature. If extrapolable, this scenario would provide an attractive operating regime for next step fusion experiment