Detection of Dark Matter Concentrations in the Field of Cl 1604+4304 from Weak Lensing Analysis

We present a weak-lensing analysis of a region around the galaxy cluster Cl 1604+4304 (z=0.897) on the basis of the deep observations with the HST/WFPC2. We apply a variant of Schneider's aperture mass technique to the observed WFPC2 field and obtain the distribution of weak-lensing signal-to-noise (S/N) ratio within the field. The resulting S/N map reveals a clear pronounced peak located about 1.7 arcmin (850h_{50}^{-1} kpc at z=0.897) southwest of the second peak associated with the optical cluster center determined from the dynamical analysis of Postman et al. A non-linear finite-field inversion method has been used to reconstruct the projected mass distribution from the observed shear field. The reconstructed mass map shows a super-critical feature at the location of the S/N peak as well as in the cluster central region. Assuming the redshift distribution of field galaxies, we obtain the total mass in the observed field to be 1.0 h_{50}^{-1} 10^{15} M_sun for =1.0. The estimated mass within a circular aperture of radius 280h_{50}^{-1} kpc centered on the dark clump is 2.4h_{50}^{-1} 10^{14} M_sun. We have confirmed the existence of the ` dark ' mass concentration from another deep HST observation with a slightly different ~20 arcsec pointing.Comment: 7 pages, 3 figure

Hawking Fluxes, Back reaction and Covariant Anomalies

Starting from the chiral covariant effective action approach of Banerjee and Kulkarni [Phys. Lett. B 659, 827(2008)], we provide a derivation of the Hawking radiation from a charged black hole in the presence of gravitational back reaction. The modified expressions for charge and energy flux, due to effect of one loop back reaction are obtained.Comment: 6 pages, no figures, minor changes and references added, to appear in Classical and Quantum Gravit

Gauge Theories in Noncommutative Homogeneous K\"ahler Manifolds

We construct a gauge theory on a noncommutative homogeneous K\"ahler manifold, where we employ the deformation quantization with separation of variables for K\"ahler manifolds formulated by Karabegov. A key point in this construction is to obtaining vector fields which act as inner derivations for the deformation quantization. We show that these vector fields are the only Killing vector fields. We give an explicit construction of this gauge theory on noncommutative ${\mathbb C}P^N$ and noncommutative ${\mathbb C}H^N$.Comment: 27 pages, typos correcte

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel.

Pexidartinib (PLX3397) is a small molecule tyrosine kinase and colony-stimulating factor-1 inhibitor with FDA breakthrough therapy designation for tenosynovial giant-cell tumor, and currently under study in several other tumor types, including breast cancer, non-Hodgkin's lymphoma, and glioblastoma. Here, we report a case of severe drug-induced liver injury requiring liver transplantation due to vanishing bile duct syndrome (VBDS) after exposure to pexidartinib in the I-SPY 2 Trial, a phase 2 multicenter randomized neoadjuvant chemotherapy trial in patients with Stage II-III breast cancer. We also review the current literature on this rare, idiosyncratic, and potentially life-threatening entity

Hawking radiation as tunneling from squashed Kaluza-Klein black hole

We discuss Hawking radiation from a five-dimensional squashed Kaluza-Klein black hole on the basis of the tunneling mechanism. A simple manner, which was recently suggested by Umetsu, is possible to extend the original derivation by Parikh and Wilczek to various black holes. That is, we use the two-dimensional effective metric, which is obtained by the dimensional reduction near the horizon, as the background metric. By using same manner, we derive both the desired result of the Hawking temperature and the effect of the back reaction associated with the radiation in the squashed Kaluza-Klein black hole background.Comment: 16 page

Subaru weak-lensing study of A2163: bimodal mass structure

We present a weak-lensing analysis of the merging cluster A2163 using Subaru/Suprime-Cam and CFHT/Mega-Cam data and discuss the dynamics of this cluster merger, based on complementary weak-lensing, X-ray, and optical spectroscopic datasets. From two dimensional multi-component weak-lensing analysis, we reveal that the cluster mass distribution is well described by three main components, including a two component main cluster A2163-A with mass ratio 1:8, and its cluster satellite A2163-B. The bimodal mass distribution in A2163-A is similar to the galaxy density distribution, but appears as spatially segregated from the brightest X-ray emitting gas region. We discuss the possible origins of this gas-dark matter offset and suggest the gas core of the A2163-A subcluster has been stripped away by ram pressure from its dark matter component. The survival of this gas core to the tidal forces exerted by the main cluster let us infer a subcluster accretion with a non-zero impact parameter. Dominated by the most massive component of A2163-A, the mass distribution of A2163 is well described by a universal Navarro-Frenk-White profile as shown by a one-dimensional tangential shear analysis, while the singular-isothermal sphere profile is strongly ruled out. Comparing this cluster mass profile with profiles derived assuming intracluster medium hydrostatic equilibrium (H.E.) in two opposite regions of the cluster atmosphere has allowed us to confirm the prediction of a departure from H.E. in the eastern cluster side, presumably due to shock heating. Yielding a cluster mass estimate of M_{500}=11.18_{-1.46}^{+1.64}\times10^{14}h^{-1}Msun, our mass profile confirm the exceptionally high mass of A2163, consistent with previous analyses relying on the cluster dynamical analysis and Yx mass proxy.Comment: 17 pages, 11 figures, ApJ, in press. Full resolution version is available at http://www.asiaa.sinica.edu.tw/~okabe/files/a2163_WL_astroph.pd

Joint Strong and Weak Lensing Analysis of the Massive Cluster Field J0850+3604

We present a combined strong and weak lensing analysis of the J085007.6+360428 (J0850) field, which was selected by its high projected concentration of luminous red galaxies and contains the massive cluster Zwicky 1953. Using Subaru/Suprime-Cam $BVR_{c}I_{c}i^{\prime}z^{\prime}$ imaging and MMT/Hectospec spectroscopy, we first perform a weak lensing shear analysis to constrain the mass distribution in this field, including the cluster at $z = 0.3774$ and a smaller foreground halo at $z = 0.2713$. We then add a strong lensing constraint from a multiply-imaged galaxy in the imaging data with a photometric redshift of $z \approx 5.03$. Unlike previous cluster-scale lens analyses, our technique accounts for the full three-dimensional mass structure in the beam, including galaxies along the line of sight. In contrast with past cluster analyses that use only lensed image positions as constraints, we use the full surface brightness distribution of the images. This method predicts that the source galaxy crosses a lensing caustic such that one image is a highly-magnified "fold arc", which could be used to probe the source galaxy's structure at ultra-high spatial resolution ($< 30$ pc). We calculate the mass of the primary cluster to be $\mathrm{M_{vir}} = 2.93_{-0.65}^{+0.71} \times 10^{15}~\mathrm{M_{\odot}}$ with a concentration of $\mathrm{c_{vir}} = 3.46_{-0.59}^{+0.70}$, consistent with the mass-concentration relation of massive clusters at a similar redshift. The large mass of this cluster makes J0850 an excellent field for leveraging lensing magnification to search for high-redshift galaxies, competitive with and complementary to that of well-studied clusters such as the HST Frontier Fields.Comment: Accepted for publication in The Astrophysical Journal; 14 pages, 13 figures, 3 table

The Surprisingly Steep Mass Profile of Abell 1689, from a Lensing Analysis of Subaru Images

Subaru observations of A1689 (z=0.183) are used to derive an accurate, model-independent mass profile for the entire cluster, r<2 Mpc/h, by combining magnification bias and distortion measurements. The projected mass profile steepens quickly with increasing radius, falling away to zero at r~1.0 Mpc/h, well short of the anticipated virial radius. Our profile accurately matches onto the inner profile, r<200 kpc/h, derived from deep HST/ACS images. The combined ACS and Subaru information is well fitted by an NFW profile with virial mass, (1.93 \pm 0.20)10^15 M_sun, and surprisingly high concentration, c_vir=13.7^{+1.4}_{-1.1}, significantly larger than theoretically expected (c_vir~4), corresponding to a relatively steep overall profile. A slightly better fit is achieved with a steep power-law model that has its 2D logarithmic slope -3 and core radius theta_c~1.7' (r_c~210 kpc/h), whereas an isothermal profile is strongly rejected. These results are based on a reliable sample of background galaxies selected to be redder than the cluster E/S0 sequence. By including the faint blue galaxy population a much smaller distortion signal is found, demonstrating that blue cluster members significantly dilute the true signal for r~400 kpc/h. This contamination is likely to affect most weak lensing results to date.Comment: 5 pages, 3 figures, to appear in ApJ

Asthma diagnosis and treatment - 1012. The efficacy of budesonide in the treatmetn of acute asthma in children: a double-blind, randomized, controlled trial.

Background Current evidence suggests that inhaled glucocorticoids (IGC) have a more profound topical none genomic effect on bronchial airways as compared to systemic glucocorticoids. The value of adding IGC to current therapy of acute asthma is not well established. Methods We conducted a double-blind, randomized, two-arm, parallel groups, controlled clinical trial to compare the addition of budesonide 1500 mcg or placebo (normal saline) to standard acute asthma treatment (albuterol and ipratropium bromide) administered in 3 divided mixed doses within 1 hour in the emergency department (ED). Children 2-12 years of age with moderate or severe acute asthma, scoring 8-15/15 on a well-validated scoring system were included. Both groups received a single dose of prednisone 2 mg/kg/day (max. 60 mg) at the beginning of therapy. The primary outcome was admission rate within 2-4 hours from starting therapy. Results A total of 723 children were enrolled in the study over 17 months duration, of whom 139 were allowed to re-enroll and be randomized to constitute 906 randomization assignments (458 on the treatment group and 448 on the control group); with baseline mean + SD asthma score of 10.63 + 1.73; age 5.52 + 2.76 years; 35% girls; 30.8% (16.5%) with baseline severe asthma score of ≥12 (≥ 13). Statistical Analysis plan allowed for the potential dependency in response due to reenrollments of a subset of children, using Generalized Linear Mixed Modeling (GLMM) techniques. Baseline demographic and clinical characteristics were not significantly different between the two randomized groups. Seventy-five out of 458 (16.4%) of the treatment group vs. 82/448 (18.3%) of the control group were admitted, (OR 0.85, CI: 0.59-1.23, p-value=0.39). Among the severe asthmatics with baseline score ≥13, treatment vs. placebo group, GLMM adjusted admission rate was 30% vs. 47%, indicating a 17% difference in admission rate in favor of the treatment group (adjusted OR of 0.49, CI: 0.25-0.95; p-value= 0.035) that indicated a 51% reduction in the risk of admission for the treatment vs. control group. Conclusions Children with baseline severe asthma score ≥13 who were treated with budesonide had a significant reduction in their admission rate