Dominance and Innovation

Do dominant or less dominant firms innovate more? Theoretically it has been shown that within an asymmetric mixed strategy game of a patent race, the less dominant firm invests more than the dominant firm. But the empirical data on patent races is divided. In this paper, we argue that the decisions that concern strategic choice in innovation may be influenced by expected relative returns. Our approach, which we call the returns-based beliefs approach, is based upon subjective probabilities. It combines a decision analytic solution concept and Luce’s (1959) probabilistic choice model. In particular, we show how the use of the returns-based beliefs approach provides support for the thesis that dominant firms invest more in R&D within an asymmetric mixed strategy game. Consequently, we argue that the returns-based beliefs approach is more in line with recent empirical studies of innovation. We also provide empirical evidence using UK R&D data across a range of industries from 2001-2006 that shows that firms’ spending on R&D is related more to their own profitability than that of their competitors, which is consistent with the returns-based beliefs approach. We discuss the managerial implications of our theoretical approach and the empirical findings

Divine competition: Religious organizations and service provision in India

This paper examines religious and non-religious service provision by religious organisations in India. We present a stylized Hotelling-style model in which two religious organisations differentiate hemselves on the strength of religious beliefs in order to compete in attracting adherents. We show in the model two central predictions: first,that the organisations will differentiate themselves on the strength of religious beliefs. Second, that in equilibrium, economic inequality makes the organisations increase their provision of non-religious services. To test this, we present unique primary survey dataon the economics of religion, collected by us between 2006 and 2010 from 568 Hindu, Muslim, Christian, Sikh and Jain religious organisations spread across 7 Indian states. We use these data to demonstrate that the organisations have substantially increasedtheir provision of non-religious services. We also provide quantitative evidence based oneconometric testing to highlight that religious organisations are differenting themselves on the strength of religious beliefs with respect to other organisations, and are also providing higher education and health services as economic inequality increases in India

The Results of Treatment with Streptomycin Plus Pyrazinamide in Patients with Active Pulmonary Tuberculosis Despite Prolonged Treatment with Isoniazid Plus PAS

This report presents the findings during a year or more of observation of 20 South Indian patients who, after an initial course of isoniazid plus PAS, were treated with streptomycin plus pyrazinamide for active pulmonary tuberculosis. The combination of streptomycin plus pyrazinamide was chosen, first, because of its likely therapeutic effectiveness, since all the patients had streptomycin-sensitive strains of bacilli, secondly, because it presented an opportunity to study supervised drug administration in domiciliary patients in a community in which the selfadministration of antituberculosis drugs could not be depended on (Fox, 1958 ; Tuberculosis Chemotherapy Centre, 1959, 1960 ; Velu et al., 1960). The patients were either unsuitable for or unwilling to undergo surgery

Communication and Marketing of Services by Religious Organizations in India

Marketing communication is a vital strategic tool for religious organizations to achieve competitive differentiation. The determinants of religious organizations’ use of direct and indirect communication channels offers valuable insights into their modus operandi. This paper uses novel primary survey data on 568 Hindu, Muslim, Christian, Sikh and Jain organizations spread over 7 major states in India that we collected over the period 2006-2008, to investigate the determinants of communication channel selection by religious organizations. The findings suggest that state-specific effects for Karnataka, Maharashtra, Uttar Pradesh and West Bengal; and religion-specific fixed effects for Muslims play a predominant and persistent role in communication channel selection decisions. Religious organizations adopt direct channels more extensively to communicate changes to non-religious service provision. In a competitive framework, religious organizations also use indirect channels more extensively in response to information received about competitors. Additionally, intensive market competition leads religious organizations to increase their use of direct channels in response to information received about competitors through direct channels. Collectively, the findings suggest that across all religions in India, marketing communication plays a very important role for religious organizations in order for them to differentiate themselves from other competitors

Colloidal Assemblies of Oriented Maghemite Nanocrystals and their NMR Relaxometric Properties

Elevated-temperature polyol-based colloidal-chemistry approach allows for the development of size-tunable (50 and 86 nm) assemblies of maghemite iso-oriented nanocrystals, with enhanced magnetization. 1H-Nuclear Magnetic Resonance (NMR) relaxometric experiments show that the ferrimagnetic cluster-like colloidal entities exhibit a remarkable enhancement (4 to 5 times) in the transverse relaxivity, if compared to that of the superparamagnetic contrast agent Endorem, over an extended frequency range (1-60 MHz). The marked increase of the transverse relaxivity r2 at a clinical magnetic field strength (1.41 T), which is 405.1 and 508.3 mM-1 s-1 for small and large assemblies respectively, allows to relate the observed response to the raised intra-aggregate magnetic material volume fraction. Furthermore, cell tests with murine fibroblast culture medium confirmed the cell viability in presence of the clusters. We discuss the NMR dispersion profiles on the basis of relaxivity models to highlight the magneto-structural characteristics of the materials for improved T2-weighted magnetic resonance images.Comment: Includes supporting informatio

Divine Competition: Religious Organisations and Service Provision in India

This paper examines religious and non-religious service provision by religious organisations in India. We present a stylized Hotelling-style model in which two religious organisations differentiate hemselves on the strength of religious beliefs in order to compete in attracting adherents. We show in the model two central predictions: first,that the organisations will differentiate themselves on the strength of religious beliefs. Second, that in equilibrium, economic inequality makes the organisations increase their provision of non-religious services. To test this, we present unique primary survey dataon the economics of religion, collected by us between 2006 and 2010 from 568 Hindu, Muslim, Christian, Sikh and Jain religious organisations spread across 7 Indian states. We use these data to demonstrate that the organisations have substantially increasedtheir provision of non-religious services. We also provide quantitative evidence based oneconometric testing to highlight that religious organisations are differenting themselves on the strength of religious beliefs with respect to other organisations, and are also providing higher education and health services as economic inequality increases in India

A Comparison of the Results of Bacteriological Examination of a Sputum Collection and a Pair of Laryngeal Swab Specimens in Patients Receiving Chemotherapy for Pulmonary Tuberculosis

pulmonary tuberculosis is of prime importance. The most valuable assessment of a treatment is its effect on the bacterial population of the sputum. A reduction in the number of organisms being excreted, or their complete elimination, is the best evidence that the patient is responding to treatment, and bacteriological negativity is the crucial desideratum of the quiescence of the disease (American Trudeau Society, 1959; Devadatta et al., 1961). In a previous report from this Centre (Andrews and Radhakrishna, 1959) a comparison was made of the results of smear and culture examinations of specimens of sputum obtained in 2 different ways from patients receiving chemotherapy. It was found that “spot” specimens, that is, specimens produced in the Centre within the course of a few minutes were less frequently positive than “collection” specimens, that is, specimens produced overnight in the home. During treatment and usually within a few months of the start of effective chemotherapy, the majority of patients find it difficult to expectorate and it, therefore, becomes of interest to study the relative usefulness of collection specimens of sputum and laryngeal swabs in detecting the presence of tubercle bacilli. This report presents the results of a comparison of an overnight collection specimen of sputum (referred to as sputum specimen in the rest of the report) with a pair of laryngeal swabs (considered as a single specimen in the laboratory) taken from patients during the third to twelfth month of anti-tuberculosis chemotherapy

Divine Innovation: Religion and Service Provision by Religious Organizations in India

This paper examines innovations to religious and non-religious service provision by religious organizations in India. We present a stylized Hotelling-style model in which two religious organizations position themselves at opposite locations to differentiate themselves on the religious spectrum in order to compete to attract adherents. Moreover, the model predicts that economic inequality can make both organizations increase their provision of non-religious services to retain adherents. In order to test our propositions, we present unique primary survey data on the economics of religion that we have collected from 2006-2008 on 568 Hindu, Muslim, Christian, Sikh and Jain religious organizations spread across seven Indian states. We use these data to provide qualitative and descriptive statistics from the survey that is consistent and provides initial support for our propositions. We show that these organizations have substantially increased their provision of religious and non-religious services, but that there are significant variations by religion. We also provide quantitative evidence based on econometric testing to highlight that Indian religious organizations are maximizing the differences in their ideology with respect to other organizations, and are also providing higher education and health services as economic inequality increases in India

Rate of Inactivation of Isoniazid in South Indian Patients with Pulmonary Tuberculosis 2. Clinical Implications in the Treatment of Pulmonary Tuberculosis with Isoniazid either Alone or in Combination with PAS

A series of studies on the rate of inactivation of isoniazid in Indian patients with pulmonary tuberculosis undergoing domiciliary chemotherapy with isoniazid, alone or in combination with p-aminosalicylic acid, has recently been undertaken by the Tuberculosis Chemotherapy Centre, Madras. In the first study, the serum isoniazid levels of the patients were determined four-and-a-half hours after intramuscular administration of a standard dose of 3 mg/kg body-weight of isoniazid and, according to whether the serum level was 0.58 μg/ml or above, or less than 0.58 μg/ml, the patient was classified as a slow or as a rapid inactivator. The present paper describes the second of these studies, in which the response to treatment of the slow and the rapid inactivators was compared. The results of this investigation suggested that there might be an association between response to treatment and rate of inactivation of isoniazid, since the slow inactivators were more often culturenegative during treatment and showed a higher proportion of individuals with bacteriologically quiescent disease at I2 months and a lower proportion with radiographic deterioration at six months than the rapid inactivators, while the slow inactivators who deteriorated radiographically or clinically to an extent warranting a change of treatment during the two years did so later than the corresponding rapid inactivators. There was slight evidence that the slow and the rapid inactivators differed in the speed of conversion to bacteriological negativity of those patients whose disease was bacteriologically quiescent at 12 months, but no evidence that they differed in the degree of positivity of sputum specimens that were positive on culture at six, nine or 12 months, or in the frequency with which the patients showed moderate or greater radiographic improvement at six months

A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis

ATI earlier report from this Centre (Tuber-culosis Chemotherapy Centre, Madras, 1964) showed that a fully supervised twice-weekly regimen of streptomycin plus high-dosage isoniazid was highly effective in the treatment of patients with newly-diagnosed bacteriologi-cally confirmed pulmonary tuberculosis. How-ever, this regimen involves intramuscular injections of streptomycin and may not always be easy to organize, especially in rural areas and in developing countries with limited resources. For this reason, it was decided to investigate the possibility of replacing strepto-mycin in the twice-weekly regimen by two oral drugs, namely ethionamide and PAS. Ethiona-mide was chosen since, apart from isoniazid and streptomycin, it was the most potent drug available at the time, and PAS was included with a view to enhance the efficacy of the regimen. Finally, it was decided that the patients should be given an intensive phase of daily treatment with streptomycin, PAS and isoniazid for two weeks. Experiments in the guinea-pig had shown that the size of the individual dose of a drug needed to be increased as the interval between successive doses was increased (Dickinson & Mitchison, 1966). As PAS is bulky and the dosage of isoniazid in the twice-weekly regimen was already high, namely 15 mg./kg. body-weight, it was decided to explore the possibility of increasing the dosage of ethionamide to a level higher than that usually employed (0.5— 1.0 g.) in daily regimens. An investigation was therefore undertaken to determine the maximum tolerated dose of ethionamide. when administered twice-weekly together with isonia-zid plus PAS. Since the assessment of ethio-namide intolerance is largely subjective, the study was conducted ‘double-blind’ with respect to the dosage of ethionamide