Executive Orders: Issuance, Modification, and Revocation

Executive orders, presidential memoranda, and proclamations are used extensively by Presidents to achieve policy goals, set uniform standards for managing the executive branch, or outline a policy view intended to influence the behavior of private citizens. The U.S. Constitution does not define these presidential instruments and does not explicitly vest the President with the authority to issue them. Nonetheless, such orders are accepted as an inherent aspect of presidential power. Moreover, if they are based on appropriate authority, they have the force and effect of law. This report discusses the nature of these written instruments, executive orders in particular, with a focus on the scope of presidential authority to execute such instruments, as well as judicial and congressional responses to their issuance

Entanglement from density measurements: analytical density-functional for the entanglement of strongly correlated fermions

We derive an analytical density functional for the single-site entanglement of the one-dimensional homogeneous Hubbard model, by means of an approximation to the linear entropy. We show that this very simple density functional reproduces quantitatively the exact results. We then use this functional as input for a local density approximation to the single-site entanglement of inhomogeneous systems. We illustrate the power of this approach in a harmonically confined system, which could simulate recent experiments with ultracold atoms in optical lattices as well as in a superlattice and in an impurity system. The impressive quantitative agreement with numerical calculations -- which includes reproducing subtle signatures of the particle density stages -- shows that our density-functional can provide entanglement calculations for actual experiments via density measurements. Next we use our functional to calculate the entanglement in disordered systems. We find that, at contrast with the expectation that disorder destroys the entanglement, there exist regimes for which the entanglement remains almost unaffected by the presence of disordered impurities.Comment: 6 pages, 3 figure

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries

Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial tortuosity, and aortic aneurysms. We sought to determine the consequences of a human disease-causing mutation in FBLN4 (E57K) on the cardiovascular system and vascular elastic fibers in a mouse model of ARCL1B. Fbln4E57K/E57K mice were hypertensive and developed arterial elongation, tortuosity, and ascending aortic aneurysms. Smooth muscle cell organization within the arterial wall of large conducting vessels was abnormal, and elastic fibers were fragmented and had a moth-eaten appearance. In contrast, vessel wall structure and elastic fiber integrity were normal in resistance/muscular arteries (renal, mesenteric, and saphenous). Elastin cross-linking and total elastin content were unchanged in large or small arteries, whereas elastic fiber architecture was abnormal in large vessels. While the E57K mutation did not affect Fbln4 mRNA levels, FBLN4 protein was lower in the ascending aorta of mutant animals compared to wild-type arteries but equivalent in mesenteric arteries. We found a differential role of FBLN4 in elastic fiber assembly, where it functions mainly in large conduit arteries. These results suggest that elastin assembly has different requirements depending on vessel type. Normal levels of elastin cross-links in mutant tissue call into question FBLN4\u27s suggested role in mediating lysyl oxidase-elastin interactions. Future studies investigating tissuespecific elastic fiber assembly may lead to novel therapeutic interventions for ARCL1B and other disorders of elastic fiber assembly. 2017 © The Authors, some rights reserved

Nutrient Addition Effects on Phytoplankton Communities in the Amazon River Plume

The types and abundance of phytoplankton is largely controlled by availability of sunlight and bioavailable nutrients. Phytoplankton require essential nutrients including nitrate, phosphate, and silicate to grow, so understanding the role of these macronutrients in limiting the growth phytoplankton communitiesand the way this may differ depending on community compositionis key to understanding the controls on phytoplankton biomass and community structure. We aimed to explore how the availability of these nutrients affects the health and composition of phytoplankton communities by conducting a series of nutrient amendment experiments (NAEs) with samples from the Western Tropical North Atlantic, which is heavily influenced by the nutrient-rich, low salinity waters of the Amazon River Plume. These experiments, conducted at five locations in and around the plume, provide greater resolution and further our understanding about the ways nutrients affect communities in dynamic coastal regions

Analyzing the Influence of Training and Development on Organizational Performance at PT. Bank Tabungan Negara (Persero) Tbk Manado

Nowadays human resource is a crucial things, so that many company implement training and development for their employees to face the competition. The objectives of this research are to analyze the influence of Training and Development on Organizational Performance at PT. Bank Tabungan Negara (Persero) Tbk, Manado. This is a quantitative research that associative with multiple linear regression analysis technique. The population in this study is the employees at PT. Bank Tabungan Negara (Persero) Tbk, Manado and the respondents are 30 peoples. This study may imply that the contribution of Training Design, On the Job Training, and Delivery Style on Organizational Performance of 86% while the remaining 14% is affected by other variables not examined in this study. For PT. Bank Tabungan Negara (Persero) Tbk, Manado in the managerial role should care about the Influence of Training and Development on Organizational Performance so that through this research the company can get more information about the fact which happens and company may improve the human resource practice especially in training and development. Keywords: training and development, organizational performanc

New dispatching paradigm in power systems including EV charging stations and dispersed generation: A real test case

Electric Vehicles (EVs) are becoming one of the main answers to the decarbonization of the transport sector and Renewable Energy Sources (RES) to the decarbonization of the electricity production sector. Nevertheless, their impact on the electric grids cannot be neglected. New paradigms for the management of the grids where they are connected, which are typically distribution grids in Medium Voltage (MV) and Low Voltage (LV), are necessary. A reform of dispatching rules, including the management of distribution grids and the resources there connected, is in progress in Europe. In this paper, a new paradigm linked to the design of reform is proposed and then tested, in reference to a real distribution grid, operated by the main Italian Distribution System Operator (DSO), e-distribuzione. First, in reference to suitable future scenarios of spread of RES-based power plants and EVs charging stations (EVCS), using Power Flow (PF) models, a check of the operation of the distribution grid, in reference to the usual rules of management, is made. Second, a new dispatching model, involving DSO and the resources connected to its grids, is tested, using an Optimal Power Flow (OPF) algorithm. Results show that the new paradigm of dispatching can effectively be useful for preventing some operation problems of the distribution grids

Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) - the leading cause of vision loss in the elderly - share many risks factors as atherosclerosis, which exhibits loss of vascular compliance resulting from aging and oxidative stress. Here, we attempt to explore choroidal and retinal vascular compliance in patients with AMD by evaluating dynamic vascular changes using live ocular imaging following treatment with oral sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor and potent vasodilator. Enhanced-depth imaging optical coherence tomography (EDI-OCT) and OCT angiography (OCT-A) were performed on 46 eyes of 23 subjects, including 15 patients with non-exudative AMD in one eye and exudative AMD in the fellow eye, and 8 age-matched control subjects. Choroidal thickness, choroidal vascularity, and retinal vessel density were measured across the central macula at 1 and 3 hours after a 100 mg oral dose of sildenafil citrate. Baseline choroidal thickness was 172.1 ± 60.0 μm in non-exudative AMD eyes, 196.4 ± 89.8 μm in exudative AMD eyes, and 207.4 ± 77.7 μm in control eyes, with no difference between the 3 groups (P = 0.116). After sildenafil, choroidal thickness increased by 6.0% to 9.0% at 1 and 3 hours in all groups (P = 0.001-0.014). Eyes from older subjects were associated with choroidal thinning at baseline (P = 0.005) and showed less choroidal expansion at 1 hour and 3 hours after sildenafil (P = 0.001) regardless of AMD status (P = 0.666). The choroidal thickening appeared to be primarily attributed to expansion of the stroma rather than luminal component. Retinal vascular density remained unchanged after sildenafil in all 3 groups (P = 0.281-0.587). Together, our studies suggest that vascular response of the choroid to sildenafil decreases with age, but is not affected by the presence of non-exudative or exudative AMD, providing insight into changes in vessel compliance in aging and AMD

Regional data exchange to improve care for veterans after non-VA hospitalization: a randomized controlled trial

BACKGROUND: Coordination of care, especially after a patient experiences an acute care event, is a challenge for many health systems. Event notification is a form of health information exchange (HIE) which has the potential to support care coordination by alerting primary care providers when a patient experiences an acute care event. While promising, there exists little evidence on the impact of event notification in support of reengagement into primary care. The objectives of this study are to 1) examine the effectiveness of event notification on health outcomes for older adults who experience acute care events, and 2) compare approaches to how providers respond to event notifications. METHODS: In a cluster randomized trial conducted across two medical centers within the U.S. Veterans Health Administration (VHA) system, we plan to enroll older patients (≥ 65 years of age) who utilize both VHA and non-VHA providers. Patients will be enrolled into one of three arms: 1) usual care; 2) event notifications only; or 3) event notifications plus a care transitions intervention. In the event notification arms, following a non-VHA acute care encounter, an HIE-based intervention will send an event notification to VHA providers. Patients in the event notification plus care transitions arm will also receive 30 days of care transition support from a social worker. The primary outcome measure is 90-day readmission rate. Secondary outcomes will be high risk medication discrepancies as well as care transitions processes within the VHA health system. Qualitative assessments of the intervention will inform VHA system-wide implementation. DISCUSSION: While HIE has been evaluated in other contexts, little evidence exists on HIE-enabled event notification interventions. Furthermore, this trial offers the opportunity to examine the use of event notifications that trigger a care transitions intervention to further support coordination of care. TRIAL REGISTRATION: ClinicalTrials.gov NCT02689076. "Regional Data Exchange to Improve Care for Veterans After Non-VA Hospitalization." Registered 23 February 2016