Mass transfer efficiency of a tall and low plate free area liquid pulsed sieve-plate extraction column

Acknowledgements The authors would like to acknowledge Chakwal group of industries for funding the project. Ms. Madiha, Ms. Zona, Mr. Sohaib, Mr. Abdullah, Mr. Mudassar, and Mr. Salahuddin also deserve our acknowledgements for their assistance in different ways.Peer reviewedPublisher PD

Coarse-grained simulations of flow-induced nucleation in semi-crystalline polymers

We perform kinetic Monte Carlo simulations of flow-induced nucleation in polymer melts with an algorithm that is tractable even at low undercooling. The configuration of the non-crystallized chains under flow is computed with a recent non-linear tube model. Our simulations predict both enhanced nucleation and the growth of shish-like elongated nuclei for sufficiently fast flows. The simulations predict several experimental phenomena and theoretically justify a previously empirical result for the flow-enhanced nucleation rate. The simulations are highly pertinent to both the fundamental understanding and process modeling of flow-induced crystallization in polymer melts.Comment: 17 pages, 6 eps figure

The Effects of Vortex Generator Types on Heat Transfer and Flow Structure in a Rectangular Duct Flows

In this numerical study a detailed evaluation of the heat transfer characteristics and flow structure in a laminar and turbulent flow through a rectangular channel containing built-in of different type vortex generator has been a accomplished in a range of Reynolds number between 500 and 100,000.A modified version of ESCEAT code has been used to solve Navier-Stokes and energy equations. The purpose of this paper is to present numerical comparisons in terms of temperature, Nusselt number and flow patterns on several configurations of longitudinal vortex generator including new five cases. The structures of heat and flow were studied, using iso-contours of velocity components, vortices, temperature and Nusselt number. This study shows that the predicted structures of fluid flow, temperature fields and Nusselt number variation are strongly affected by the presence of the turbulators. Staggered arrangement gains high Nusselt number, also the lower and upper arrangements have higher Nusselt number than plane duct. High Reynolds number (higher air inlet velocity) will enhance the Nusselt number. Increase in ribs height will enhance the heat transfer as it works as surface area and turbulator at the same time

A review and comparison of efficient flooding schemes for on-demand routing protocols on mobile ad hoc networks (MANETs)

Since the basic components of ad hoc wireless networks are mostly battery-operated portable devices, power conservation is one of the central issues of such networks. Power-conservative designs for ad hoc networks pose many challenges due to the lack of central coordination facilities. Existing on-demand routing protocols perform route discovery by flooding the network with a query message requesting a route to the destination. Flooding is used because of its simplicity and greater success in finding the best route between the source and destination available at that time of route discovery. However, as flooding involves querying all reachable network nodes, frequent flooding can rapidly deplete the energy reserved at each node. In addition to consuming significant portions of the available network bandwidth. Further, as the number of communicating nodes increases, more congestion, contention, and collisions can be expected. This paper reviews and compares approaches for optimizing bandwidth efficiency of route discovery, where several efficient flooding schemes have been presented based on different techniques to solve the problems related with the traditional blind flooding

Dual-acting stapled peptides target both HIV-1 entry and assembly

Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD) of the HIV-1 capsid (CA) protein with an improved affinity (Kd ~ 1 μM) compared to CAI (Kd ~ 15 μM). NYAD-1 disrupts the formation of both immature- and mature-like virus particles in in vitro and cell-based assembly assays. In addition, it displays potent anti-HIV-1 activity in cell culture against a range of laboratory-adapted and primary HIV-1 isolates.<p></p> Results: In this report, we expanded the study to i,i + 7 hydrocarbon-stapled peptides to delineate their mechanism of action and antiviral activity. We identified three potent inhibitors, NYAD-36, -66 and -67, which showed strong binding to CA in NMR and isothermal titration calorimetry (ITC) studies and disrupted the formation of mature-like particles. They showed typical α-helical structures and penetrated cells; however, the cell penetration was not as efficient as observed with the i,i + 4 peptides. Unlike NYAD-1, the i,i + 7 peptides did not have any effect on virus release; however, they impaired Gag precursor processing. HIV-1 particles produced in the presence of these peptides displayed impaired infectivity. Consistent with an effect on virus entry, selection for viral resistance led to the emergence of two mutations in the gp120 subunit of the viral envelope (Env) glycoprotein, V120Q and A327P, located in the conserved region 1 (C1) and the base of the V3 loop, respectively.<p></p> Conclusion: The i,i + 7 stapled peptides derived from CAI unexpectedly target both CA and the V3 loop of gp120. This dual-targeted activity is dependent on their ability to penetrate cells as well as their net charge. This mechanistic revelation will be useful in further modifying these peptides as potent anti-HIV-1 agents.<p></p&gt

The Effect of Power factor Improvement on Switching Transients: A Case of FUMMAN Agricultural Products Industry Plc.

Industrial loads are mostly inductive and hence operate at low power factor. Several methods including the installation of capacitor banks are available for improving power factor in order to reduce the kilovolt ampere (kVA) demand of the load and power loss from the power supply system. However, literatures have shown that improvement of power factor has effect on switching transients which is dangerous for industrial loads and operating personnel. In this work, we investigated the effect of improving the power factor of a power system beyond 0.8 (lagging) on switching transient levels using FUMMAN industry power network as a case study. A power factor measuring tool was modelled using the mathematical relation between power factor, reactive power and active power. The modelled equations were simulated Matlab/Simulink software (Version 7.9.0.529 ‘R2009b’). The characteristics of the system under study namely root mean square (r.m.s) voltage, peak steady state voltage, peak transient voltage and kVA demand were measured during the simulation with and without parallel connection of capacitor bank across the system. The result from the analysis showed that FUMMAN industry power network was operating at a lagging power factor of 0.8 with r.m.s voltage of 412.1 V, peak steady state voltage of 582.8 V, peak transient voltage of 701.9 V and kVA demand of 1878 kVA without the capacitor bank. However, when a capacitor bank was connected across the system and the power factor increased from 0.8 (lagging) to 0.9098 (lagging), optimised performance of the system was obtained with a capacitor bank size of 440 kVar. At lagging power factor of 0.9098, the kVA demand of the system was 1650 kVA, r.m.s voltage was 415.5 V and peak transient voltage was 749.5 V. The analysis therefore showed that increasing power factor beyond 0.8 (lagging) using capacitor banks though improves the r.m.s voltage and reduces the power loss but invariably leads to increase in switching transients which is undesired for optimised system performance

Punctate Inner Choroidopathy: A Review

Punctate Inner Choroidopathy (PIC), an idiopathic inflammatory multifocal chorioretinopathy that predominantly affects young myopic women, appears to be relatively rare, but there is limited data to support accurate estimates of prevalence, and it is likely that the condition is under-diagnosed. The etiological relationship between PIC and other conditions within the 'white dot syndromes' group remains uncertain. We, like others, would suggest that PIC and multifocal choroiditis with panuveitis (MCP) represent a single disease process that is modified by host factors (including host immunoregulation) to cause the range of clinical phenotypes seen. The impact of PIC on the patient is highly variable, with outcome ranging from complete spontaneous recovery to bilateral severe sight-loss. Detection and monitoring has been greatly facilitated by modern scanning techniques, especially OCT and autofluorescence imaging, and may be enhanced by co-registration of sequential images to detect change over time. Depending on the course of disease and nature of complications, appropriate treatment may range from observation to systemic immunosuppression and anti-angiogenic therapies. PIC is a challenging condition where treatment has to be tailored to the patient's individual circumstances, the extent of disease, and the risk of progression

Comparative Study of the Use of Insect Meal from Spodoptera littoralis and Bactrocera zonata for Feeding Japanese Quail Chicks

A transformation of current livestock production towards a more sustainable operation is crucial to face nutritional and environmental challenges. There is an urgent demand for more sustainable high-quality feed sources to reduce environmental costs. Insects pose a potential alternative since they can be reared sustainably on food and feed residues. Know-how in mass rearing already exists for insect species used in biological pest control, such as the African cotton leafworm Spodoptera littoralis and the peach fruit fly Bactrocera zonata. The impact of a replacement of 50% of soybean meal by S. littoralis and B. zonata meal, respectively, on seven-days-old Japanese quail chicks was investigated in feeding trials. Concomitantly, the chemical compositions of the two insect meals and soybean meal were determined and compared. It was observed that the insect meals had higher protein and fat contents, lower carbohydrate contents and contained more saturated fatty acids than soybean meal. They also had higher methionine, and S. littoralis had a higher lysine content. Feeding trials resulted in improved growth, feed performance parameters, carcass characteristics, and biochemical indices for both insect meals. Consequently, both insect meals represent a promising alternative to soy in the feed of Japanese quail chicks.DFG, 414044773, Open Access Publizieren 2019 - 2020 / Technische Universität Berli

Knowledge of primary paediatric care providers regarding attention deficit hyperactivity disorder and learning disorder: a study from Pakistan

Introduction: Attention deficit hyperactivity disorder (ADHD) and learning disorder (LD) remain prevalent globally and are also speculated to have a high occurrence in Pakistan. An early diagnosis and intervention in these disabilities is imperative for achieving good clinical and functional outcomes. This can be ensured by an effective screening at the level of primary paediatric care in the developing countries. We aimed to explore the ability of general practitioners (GPs) and paediatricians in Pakistan to screen for ADHD and LD based on their awareness regarding the risk factors and symptomatology of ADHD and LD. Methods: A total of 96 paediatricians and 98 GPs practising in Karachi, Pakistan were included in the study. Data was collected employing a self-administered questionnaire. Results: Only 13.7 percent of the GPs and 21.6 percent of the paediatricians were shown to have knowledge sufficient to effectively screen for / diagnose ADHD. Alarmingly, not a single GP was adequately familiar with the established risk factors and clinical symptoms of LD. The level of knowledge was not influenced by age, gender, and clinical practice attributes of the physicians. Doctors who regularly read medical journals and attend medical education seminars showed slightly better trends. Conclusion : We hypothesise that this demonstrated lack of knowledge at the level of primary care in Pakistan prevents an early screening of ADHD and LD. A multipronged strategy targeted at the provision of objective screening tools for primary paediatric care providers, regular continuing medical education seminars and an emphasis on paediatric mental health in undergraduate and postgraduate curricula may ensure an early detection of ADHD and LD in Pakistan