The age of white dwarf companions

Original paper can be found at: http://www.iop.org/EJ/conf DOI: 10.1088/1742-6596/172/1/012019 [16th European White Dwarfs Workshop]We carried out a spectroscopic investigation of single lined white dwarfs (WDs) in double degenerate (DD) systems and discuss their binary evolution. Simulated spectra of the Hα region are used to derive upper limits on the temperature of the invisible component and thus lower limits on the cooling age. This is done for a range of hypothetical secondary masses and a minimum cooling age deduced. Results are compared with the well known parameters of the visible primary, which allows us to determine a lower limit for the cooling age difference of both WDs. Most of the ten systems in our sample have a minimum age difference of not larger than 0.5 Gyr and their small orbital separation is highly suggestive of at least one unstable mass transfer phase. However, a stable first mass transfer phase is feasible as the age difference is less then 1 Gyr. The results imply that unstable mass transfer is the most likely final contact binary scenario to have occurred in DD systems but the first mass transfer phase is not constrained.Peer reviewe

Group B streptococcal infection and activation of human astrocytes.

BACKGROUND:Streptococcus agalactiae (Group B Streptococcus, GBS) is the leading cause of life-threatening meningitis in human newborns in industrialized countries. Meningitis results from neonatal infection that occurs when GBS leaves the bloodstream (bacteremia), crosses the blood-brain barrier (BBB), and enters the central nervous system (CNS), where the bacteria contact the meninges. Although GBS is known to invade the BBB, subsequent interaction with astrocytes that physically associate with brain endothelium has not been well studied. METHODOLOGY/PRINCIPAL FINDINGS:We hypothesize that human astrocytes play a unique role in GBS infection and contribute to the development of meningitis. To address this, we used a well- characterized human fetal astrocyte cell line, SVG-A, and examined GBS infection in vitro. We observed that all GBS strains of representative clinically dominant serotypes (Ia, Ib, III, and V) were able to adhere to and invade astrocytes. Cellular invasion was dependent on host actin cytoskeleton rearrangements, and was specific to GBS as Streptococcus gordonii failed to enter astrocytes. Analysis of isogenic mutant GBS strains deficient in various cell surface organelles showed that anchored LTA, serine-rich repeat protein (Srr1) and fibronectin binding (SfbA) proteins all contribute to host cell internalization. Wild-type GBS also displayed an ability to persist and survive within an intracellular compartment for at least 12 h following invasion. Moreover, GBS infection resulted in increased astrocyte transcription of interleukin (IL)-1β, IL-6 and VEGF. CONCLUSIONS/SIGNIFICANCE:This study has further characterized the interaction of GBS with human astrocytes, and has identified the importance of specific virulence factors in these interactions. Understanding the role of astrocytes during GBS infection will provide important information regarding BBB disruption and the development of neonatal meningitis

The impact of the AuScope VLBI observations and the regional AUSTRAL sessions on the TRF

The AuScope VLBI array was built with the purpose to improve the terrestrial (TRF) and celestial reference frames in the southern hemisphere. Since 2010 the three 12-m antennas in Hobart (Tasmania), Katherine (Northern Territory) and Yarragadee (Western Australia) heavily contribute to the global VLBI observations coordinated by the International VLBI Service for Geodesy and Astrometry. In 2011, the AUSTRAL VLBI program was started, with more than 40 sessions being observed so far. In the AUSTRALs, the three AuScope antennas observe together with the new 15-m dish in Hartebeesthoek (South Africa) and the 12-m antenna in Warkworth (New Zealand). Recently, the planned observations have been expanded again, with 50 additional sessions scheduled until mid-2015, along with 3 continuous campaigns covering 15 days each. All AUSTRALs are recorded with an increased data rate of 1 Gbps, allowing to compensate for the reduced sensitivity of the generally smaller dish size. We evaluate the positive impact of the AuScope VLBI program on the global TRF. This is due to the increased number of observations and the improved homogeneity of the global VLBI network. All data collected within this intense observing program is analysed and geodetic results are presented. This includes time series of baseline lengths and station coordinates of the contributing stations. We compare the results obtained within the regional AUSTRAL sessions with the ones of the classical global VLBI networks and identify superiorities and shortcomings of both. The high number of sessions gives high accuracies and good repeatabilities of the determined parameters. Additionally, remaining variations of baseline lengths can be identified and are compared against by default un-modelled station motions due to hydrology and atmosphere loading. Finally, we give an outlook on future plans for the AuScope antennas and the AUSTRAL observing program: on future operations, expected improvements through hardware upgrades as well as research on the use of sibling telescopes available at two sites within the AUSTRAL array (Hobart and Hartebeesthoek)

Initial findings from a mixed-methods feasibility and effectiveness evaluation of the 'Breaking Free Health an Justice' treatment and recovery programme for substance misuse in prison settings

Reshaping substance misuse treatment in prisons is central to the UK Government’s drive to address substance dependence in the prison population and reduce substance-related offending and recidivism. Therefore, a through-care project to support prisoners released from custody to community, “Gateways”, is taking place across North-West England. Amongst support with housing, education, training and employment, Gateways incorporates the Breaking Free Online (BFO) substance misuse treatment programme. Aims: To explore BFO’s potential to provide support to prisoners’ substance misuse recovery and continuity of care post-release, and examine quantitative outcomes provided by prisoners who have used the programme. Methods: Qualitative interviews with prisoners and analyses of quantitative psychometric data collected pre- and post-intervention. Findings: Themes emerging from qualitative data around prisoners’ experiences of engaging with BFO illustrate its potential for use in prison settings and also upon release to the community. Significant quantitative improvements to quality of life, severity of substance dependence and aspects of recovery progression illustrate initial effectiveness of BFO. Conclusions: The BFO programme demonstrates potential in providing effective treatment for offenders with substance misuse difficulties, and specifically in delivering continuity of care following release to the community

Experimental test of universal complementarity relations

Complementarity restricts the accuracy with which incompatible quantum observables can be jointly measured. Despite popular conception, the Heisenberg uncertainty relation does not quantify this principle. We report the experimental verification of universally valid complementarity relations, including an improved relation derived here. We exploit Einstein-Poldolsky-Rosen correlations between two photonic qubits, to jointly measure incompatible observables of one. The product of our measurement inaccuracies is low enough to violate the widely used, but not universally valid, Arthurs-Kelly relation.Comment: 8 pages, 4 figure

Using the ‘recovery’ and ‘rehabilitation’ paradigms to support desistence of substance-involved offenders: Exploration of dual and multi-focus interventions (Invited Paper)

Purpose The links between substance use and offending are well evidenced in the literature, and increasingly, substance misuse recovery is being seen as a central component of the process of rehabilitation from offending, with substance use identified as a key criminogenic risk factor. In recent years, research has demonstrated the commonalities between recovery and rehabilitation, and the possible merits of providing interventions to substance-involved offenders that address both problematic sets of behaviours. The purpose of this paper is to provide an overview of the links between substance use and offending, and the burgeoning literature around the parallel processes of recovery and rehabilitation. Design/methodology/approach This is provided as a rationale for a new treatment approach for substance-involved offenders, Breaking Free Online (BFO), which has recently been provided as part of the “Gateways” throughcare pathfinder in a number of prisons in North-West England. The BFO programme contains specific behaviour change techniques that are generic enough to be applied to change a wide range of behaviours, and so is able to support substance-involved offenders to address their substance use and offending simultaneously. Findings This dual and multi-target intervention approach has the potential to address multiple, associated areas of need simultaneously, streamlining services and providing more holistic support for individuals, such as substance-involved offenders, who may have multiple and complex needs. Practical implications Given the links between substance use and offending, it may be beneficial to provide multi-focussed interventions that address both these behaviours simultaneously, in addition to other areas of multiple and complex needs. Specifically, digital technologies may provide an opportunity to widen access to such multi-focussed interventions, through computer-assisted therapy delivery modalities. Additionally, using digital technologies to deliver such interventions can provide opportunities for joined-up care by making interventions available across both prison and community settings, following offenders on their journey through the criminal justice system. Originality/value Recommendations are provided to other intervention developers who may wish to further contribute to widening access to such dual- and multi-focus programmes for substance-involved offenders, based on the experiences developing and evidencing the BFO programme