Detecting multineuronal temporal patterns in parallel spike trains

We present a non-parametric and computationally efficient method that detects spatiotemporal firing patterns and pattern sequences in parallel spike trains and tests whether the observed numbers of repeating patterns and sequences on a given timescale are significantly different from those expected by chance. The method is generally applicable and uncovers coordinated activity with arbitrary precision by comparing it to appropriate surrogate data. The analysis of coherent patterns of spatially and temporally distributed spiking activity on various timescales enables the immediate tracking of diverse qualities of coordinated firing related to neuronal state changes and information processing. We apply the method to simulated data and multineuronal recordings from rat visual cortex and show that it reliably discriminates between data sets with random pattern occurrences and with additional exactly repeating spatiotemporal patterns and pattern sequences. Multineuronal cortical spiking activity appears to be precisely coordinated and exhibits a sequential organization beyond the cell assembly concept

Detecting planets in protoplanetary disks: A prospective study

We investigate the possibility to find evidence for planets in circumstellar disks by infrared and submillimeter interferometry. We present simulations of a circumstellar disk around a solar-type star with an embedded planet of 1 Jupiter mass. The three-dimensional (3D) density structure of the disk results from hydrodynamical simulations. On the basis of 3D radiative transfer simulations, images of this system were calculated. The intensity maps provide the basis for the simulation of the interferometers VLTI (equipped with the mid-infrared instrument MIDI) and ALMA. While MIDI/VLTI will not provide the possibility to distinguish between disks with or without a gap on the basis of visibility measurements, ALMA will provide the necessary basis for a direct gap detection.Comment: 5 page

Large-scale Vortices in Protoplanetary Disks: On the observability of possible early stages of planet formation

We investigate the possibility of mapping large-scale anti-cyclonic vortices, resulting from a global baroclinic instability, as pre-cursors of planet formation in proto-planetary disks with the planned Atacama Large Millimeter Array (ALMA). On the basis of three-dimensional radiative transfer simulations, images of a hydrodynamically calculated disk are derived which provide the basis for the simulation of ALMA. We find that ALMA will be able to trace the theoretically predicted large-scale anti-cyclonic vortex and will therefore allow testing of existing models of this very early stage of planet formation in circumstellar disks.Comment: Accepted by ApJ (Letters section). A preprint version with high-quality figures can be downloaded from http://spider.ipac.caltech.edu/staff/swolf/homepage/public/preprints/ vortex.ps.g

Effect of dust grain porosity on the appearance of protoplanetary disks

We theoretically analyze protoplanetary disks consisting of porous dust grains. In the analysis of observations of protoplanetary disks the dust phase is often assumed to consist of spherical grains, allowing one to apply the Mie scattering formalism. However, in reality, the shape of dust grains is expected to deviate strongly from that of a sphere. We investigate the influence of porous dust grains on the temperature distribution and observable appearance of protoplanetary disks for dust grain porosities of up to 60 %. We performed radiative transfer modeling to simulate the temperature distribution, spectral energy distribution, and spatially resolved intensity and polarization maps. The optical properties of porous grains were calculated using the method of discrete dipole approximation. We find that the flux in the optical wavelength range is for porous grains higher than for compact, spherical grains. The profile of the silicate peak at 9.7 um strongly depends on the degree of grain porosity. The temperature distribution shows significant changes in the direction perpendicular to the midplane. Moreover, simulated polarization maps reveal an increase of the polarization degree by a factor of about four when porous grains are considered, regardless of the disk inclination. The polarization direction is reversed in selected disk regions, depending on the wavelength, grain porosity, and disk inclination. We discuss several possible explanations of this effect and find that multiple scattering explains the effect best. Porosity influences the observable appearance of protoplanetary disks. In particular, the polarization reversal shows a dependence on grain porosity. The physical conditions within the disk are altered by porosity, which might have an effect on the processes of grain growth and disk evolution.Comment: 12 pages, 18 figure

Southern California marine sport fishing from privately owned boats: catch and effort for October-December 1982

The catch landed and effort expended by private-boat sport fishermen were studied in southern California marine waters between October and December 1982, to determine the impact of one segment of the sport fishery on local marine resources. Fishermen returning from fishing trips were interviewed at launch ramps, hoists, and boat-rental facilities. This report contains quantitative data and statistical estimates of total effort, total catch, catch of preferred species, and length frequencies for those species whose catches are regulated by minimum size limits. An estimated 157,000 organisms were landed by 57,700 anglers and 4800 divers. The major components of the angler catch were Pacific mackerel, Scomber japonicus (28,700 estimated catch): white croaker, Genyonemus lineatus (24,000 estimated catch); and Pacific bonito, Sarda chiliensis (16,700 estimated catch). These three species represented almost half the total estimated angler catch. Rockfishes, Sebastes spp: were a major catch component; the 35 rockfish species landed made up 24% of the estimated catch. Divers landed an estimated 14,700 fishes and invertebrates. Chief among these were abalone, Haliotis spp. (4200 estimated catch); rock scallop, Hinnites rugosus (3600 estimated catch); and California spiny lobster, Panulirus interruptus (2500 estimated catch). Angler and diver compliance with size-limit regulations was generally favorable, with diver compliance being particularly scrupulous, especially with invertebrate species. The compliance rate for California halibut, Paralichthys californicus, showed a drop from the previous quarter (July - September 1982) from 70 to 59% legal. During the same time period, size-limit compliance rose from 4 to 20% for Pacific bonito, a species with a tolerance allowing the take of some under-sized fish. (28p.

Debris Disk Radiative Transfer Simulation Tool (DDS)

A WWW interface for the simulation of spectral energy distributions of optically thin dust configurations with an embedded radiative source is presented. The density distribution, radiative source, and dust parameters can be selected either from an internal database or defined by the user. This tool is optimized for studying circumstellar debris disks where large grains are expected to determine the far-infrared through millimeter dust reemission spectral energy distribution. The tool is available at http://aida28.mpia-hd.mpg.de/~swolf/ddsComment: Comp. Phys. Comm, 2005, in pres

Justifications in Constraint Handling Rules for Logical Retraction in Dynamic Algorithms

We present a straightforward source-to-source transformation that introduces justifications for user-defined constraints into the CHR programming language. Then a scheme of two rules suffices to allow for logical retraction (deletion, removal) of constraints during computation. Without the need to recompute from scratch, these rules remove not only the constraint but also undo all consequences of the rule applications that involved the constraint. We prove a confluence result concerning the rule scheme and show its correctness. When algorithms are written in CHR, constraints represent both data and operations. CHR is already incremental by nature, i.e. constraints can be added at runtime. Logical retraction adds decrementality. Hence any algorithm written in CHR with justifications will become fully dynamic. Operations can be undone and data can be removed at any point in the computation without compromising the correctness of the result. We present two classical examples of dynamic algorithms, written in our prototype implementation of CHR with justifications that is available online: maintaining the minimum of a changing set of numbers and shortest paths in a graph whose edges change.Comment: Pre-proceedings paper presented at the 27th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2017), Namur, Belgium, 10-12 October 2017 (arXiv:1708.07854

Comparison of symptoms, healthcare utilization, and treatment in diagnosed and undiagnosed individuals with diarrhea-predominant irritable bowel syndrome

OBJECTIVES: Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by symptoms including abdominal pain and altered bowel function. Up to 75% of individuals with IBS may be undiagnosed. The aim of this study was to characterize symptoms, healthcare utilization, and treatments in populations with both diagnosed and undiagnosed IBS. METHODS: An online survey was conducted to compare gastrointestinal (GI) symptoms, healthcare visits, well-being, symptom management, and treatment satisfaction in individuals with and without medically diagnosed IBS (Rome III criteria). Symptom severity, disruptiveness, and treatment satisfaction were rated using a 7-point scale. Adjustments to daily life were determined by predefined survey responses. RESULTS: A total of 1,924 individuals with a history of GI symptoms were eligible and completed the survey. Of these, 1,094 individuals (56.9%) met the criteria for IBS; 830 individuals (43.1%) had no medical diagnosis of IBS despite meeting diagnostic criteria. Most participants received a diagnosis from either gastroenterologists (45%) or primary care physicians (42%). A greater percentage of diagnosed patients had severe GI symptoms (score ≥6) vs. undiagnosed individuals (16% vs. 8%, respectively; P<0.05); diagnosed patients were more likely to report that GI symptoms adversely affected their quality of life. Approximately 40% of participants received IBS-related treatment from primary care physicians; 26% and 43% of diagnosed and undiagnosed individuals, respectively, were not receiving treatment for GI symptoms. CONCLUSIONS: Many individuals with IBS-related symptoms have not been medically diagnosed with IBS. IBS-related symptoms impact quality of life, yet more than one-third of individuals are not receiving treatment for IBS