866 research outputs found
One-loop renormalisation of N=1/2 supersymmetric gauge theory with a superpotential
We construct a superpotential for the general N=1/2 supersymmetric gauge
theory coupled to chiral matter in the fundamental and adjoint representations,
and investigate the one-loop renormalisability of the theories.Comment: 67 pages, including 17 figures. Plain TeX. Uses Harvmac and epsf.
Combined and condensed version of hep-th/0607194 and hep-th/0607195 with some
added material including in particular a generalisation of the Lunin-Rey
classification of potentially divergent operator
Shared reading of children's interactive picture books
We report on a study of children and parents shared reading of interactive printed books. We investigated the differences between books with interactive features and books with expressive typography in order to evaluate which features within a book encouraged interaction between the reading participants and the book. 11 parent and child groups took part in the study that involved three observed reading sessions. From our observations we offer suggestions for the development of books and eBooks to encourage shared reading practices
Women, know your limits: Cultural sexism in academia
Despite the considerable advances of the feminist movement across Western societies, in Universities women are less likely to be promoted, or paid as much as their male colleagues, or even get jobs in the first place. One way in which we can start to reflect on why this might be the case is through hearing the experiences of women academics themselves. Using feminist methodology, this article attempts to unpack and explore just some examples of
‘cultural sexism’ which characterise the working lives of many women in British academia.This article uses qualitative methods to describe and make sense of just some of those experiences. In so doing, the argument is also made that the activity of academia is profoundly gendered and this explicit acknowledgement may contribute to our
understanding of the under-representation of women in senior positions
Word order in Topic-Focus structures in the Balkan languages
The paper examines the word order patterns of Balkan languages with respect to the representation of the discourse categories of Topic and Focus in the Left Periphery of the Balkan clause. It is argued that Balkan languages share a number of syntactic properties relevant to the discourse organization of their embeddded clauses, and it is claimed that such discourse similarities must have been favored by multi-linguistic speakers in contact situations, in particular those that led to the establishment of the Balkan Srachbund
What is History and How Do We Study History?
This lesson plan, crafted during the Bard Early College Fellowship, details a six-lesson series to help set the foundations of writing a historical research paper by asking students to answer the following questions: Why does history matter? How do we study history
The Calar Alto Deep Imaging Survey: K-band Galaxy Number Counts
We present K-band number counts for the faint galaxies in the Calar Alto Deep
Imaging Survey (CADIS). We covered 4 CADIS fields, a total area of 0.2deg^2, in
the broad band filters B, R and K. We detect about 4000 galaxies in the K-band
images, with a completeness limit of K=19.75mag, and derive the K-band galaxy
number counts in the range of 14.25 < K < 19.75mag. This is the largest medium
deep K-band survey to date in this magnitude range. The B- and R-band number
counts are also derived, down to completeness limits of B=24.75mag and
R=23.25mag. The K-selected galaxies in this magnitude range are of particular
interest, since some medium deep near-infrared surveys have identified breaks
of both the slope of the K-band number counts and the mean B-K color at
K=17\sim18mag. There is, however, a significant disagreement in the K-band
number counts among the existing surveys. Our large near-infrared selected
galaxy sample allows us to establish the presence of a clear break in the slope
at K=17.0mag from dlogN/dm = 0.64 at brighter magnitudes to dlogN/dm = 0.36 at
the fainter end. We construct no-evolution and passive evolution models, and
find that the passive evolution model can simultaneously fit the B-, R- and
K-band number counts well. The B-K colors show a clear trend to bluer colors
for K > 18mag. We also find that most of the K=18-20mag galaxies have a B-K
color bluer than the prediction of a no-evolution model for an L_* Sbc galaxy,
implying either significant evolution, even for massive galaxies, or the
existence of an extra population of small galaxies.Comment: Accepted for A&A, 10 pages, 7 figure
Lenalidomide for the Treatment of Low- or Intermediate-1-Risk Myelodysplastic Syndromes Associated with Deletion 5q Cytogenetic Abnormality: An Evidence Review of the NICE Submission from Celgene
The National Institute for Health and Care Excellence (NICE) invited the manufacturer of lenalidomide (Celgene) to submit evidence of the clinical and cost effectiveness of the drug for treating adults with myelodysplastic syndromes (MDS) associated with deletion 5q cytogenetic abnormality, as part of the Institute’s single technology appraisal (STA) process. Kleijnen Systematic Reviews Ltd (KSR), in collaboration with Erasmus University Rotterdam, was commissioned to act as the Evidence Review Group (ERG). This paper describes the company’s submission, the ERG review, and the NICE’s subsequent decisions. The ERG reviewed the evidence for clinical and cost effectiveness of the technology, as submitted by the manufacturer to the NICE. The ERG searched for relevant additional evidence and validated the manufacturer’s decision analytic model to examine the robustness of the cost-effectiveness results. Clinical effectiveness was obtained from a three-arm, European, randomized, phase III trial among red blood cell (RBC) transfusion-dependent patients with low-/intermediate-1-risk del5q31 MDS. The primary endpoint was RBC independence for ≥26 weeks, and was reached by a higher proportion of patients in the lenalidomide 10 and 5 mg groups compared with placebo (56.1 and 42.6 vs 5.9 %, respectively; both p < 0.001). The option of dose adjustments after 16 weeks due to dose-limiting toxicities or lack of response made long-term effectiveness estimates unreliable, e.g. overall survival (OS). The de novo model of the manufacturer included a Markov state-transition cost-utility model implemented in Microsoft Excel. The base-case incremental cost-effectiveness ratio (ICER) of the manufacturer was £56,965. The ERG assessment indicated that the modeling structure represented the course of the disease; however, a few errors were identified and some of the input parameters were challenged. In response to the appraisal documentation, the company revised the economic model, which increased the ICER to £68,125 per quality-adjusted life-year. The NICE Appraisal Committee (AC) did not recommend lenalidomide as a cost-effective treatment. Subsequently, the manufacturer submitted a Patient Access Scheme (PAS) that provided lenalidomide free of charge for patients who remained on treatment after 26 cycles. This PAS improved the ICER to £25,300, although the AC considered the proportion of patients who received treatment beyond 26 cycles, and hence the ICER, to be uncertain. Nevertheless, the AC accepted a commitment from the manufacturer to publish, once available, data on the proport
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