R A P I D C O M M U N I C AT I O N Nonclassical hydrodynamic behavior of Sn plasma irradiated with a long duration CO 2 laser pulse

Abstract It was found that the electron density scale length of Sn plasma irradiated with a long duration CO 2 laser pulse is much shorter than that predicted by the classical isothermal model. The experimentally observed small dominant region of in-band (2% bandwidth) 13.5-nm extreme ultraviolet (EUV) emission coincides with this constrained hydrodynamic behavior. The lower hydrodynamic efficiency may come from the strongly inhibited ablation mass and makes a CO 2 -laser-produced Sn plasma suitable as an EUV radiation source. When an intense laser pulse arrives at the surface of a solid material placed in a vacuum, a thin layer of the material is ablated, heated, and expands into vacuum due to the thermal gradient. Such hydrodynamic expansion of a laser-produced plasma has been studied for more than 40 years motivated by a wide range of applications, such as efficient compression of a pellet in laser fusion, X-ray lasers, laser ion acceleration, and short wavelength radiation sources For the application of laser fusion, a lot of effort has been expended to enhance hydrodynamic efficiency in order to achieve efficient compression of the fusion pellet. It has been shown that short wavelength lasers could provide higher hydrodynamic efficiency as compared with long wavelength lasers Experiments are carried out using a home-built master oscillator and power amplifier (MOPA) CO 2 laser system as the pumping laser puls

R A P I D C O M M U N I C AT I O N Nonclassical hydrodynamic behavior of Sn plasma irradiated with a long duration CO 2 laser pulse

Abstract It was found that the electron density scale length of Sn plasma irradiated with a long duration CO 2 laser pulse is much shorter than that predicted by the classical isothermal model. The experimentally observed small dominant region of in-band (2% bandwidth) 13.5-nm extreme ultraviolet (EUV) emission coincides with this constrained hydrodynamic behavior. The lower hydrodynamic efficiency may come from the strongly inhibited ablation mass and makes a CO 2 -laser-produced Sn plasma suitable as an EUV radiation source. When an intense laser pulse arrives at the surface of a solid material placed in a vacuum, a thin layer of the material is ablated, heated, and expands into vacuum due to the thermal gradient. Such hydrodynamic expansion of a laser-produced plasma has been studied for more than 40 years motivated by a wide range of applications, such as efficient compression of a pellet in laser fusion, X-ray lasers, laser ion acceleration, and short wavelength radiation sources For the application of laser fusion, a lot of effort has been expended to enhance hydrodynamic efficiency in order to achieve efficient compression of the fusion pellet. It has been shown that short wavelength lasers could provide higher hydrodynamic efficiency as compared with long wavelength lasers Experiments are carried out using a home-built master oscillator and power amplifier (MOPA) CO 2 laser system as the pumping laser puls

Nonclassical hydrodynamic behavior of Sn plasma irradiated with a long duration CO2 laser pulse

It was found that the electron density scale length of Sn plasma irradiated with a long duration CO2 laser pulse is much shorter than that predicted by the classical isothermal model. The experimentally observed small dominant region of in-band (2% bandwidth) 13.5-nm extreme ultraviolet (EUV) emission coincides with this constrained hydrodynamic behavior. The lower hydrodynamic efficiency may come from the strongly inhibited ablation mass and makes a CO2-laser-produced Sn plasma suitable as an EUV radiation source

Is serum‐derived exosomal hTERT transcript a marker of oncogenic activity in primary brain tumors? An exploratory study

Abstract Background In order to proliferate indefinitely, all tumors require a telomere maintenance mechanism. The expression of human telomerase reverse transcriptase (hTERT) enables telomere maintenance and provides cancer cells with limitless replicative potential. As such, it may serve as an attractive biomarker for oncogenic activity. This study explored whether a liquid biopsy that analyses blood derived exosomal hTERT transcript (e‐hTERT‐trans) may serve as such a biomarker in gliomas and meningiomas when compared to healthy controls. Methods Exosomes were isolated from the pre‐operative sera of patients' samples stored in the biobank of both Rabin and Sheba Medical Centers. The levels of e‐hTERT‐trans were measured in 81 healthy controls, 117 meningiomas, 17 low‐grade gliomas, and 61 glioblastomas. Clinical parameters of the patients were collected retrospectively and compared to the levels of the e‐hTERT‐trans. Results The upper normal limit of controls e‐hTERT‐trans was 1.85 relative quantitation (RQ). The rate of detection increased with rising tumor grade and correlated with tumor recurrence in meningiomas: mean RQ without recurrence (2.17 ± 11.7) versus with recurrence (3.59 ± 4.42; p = 0.002). In glioblastomas, preoperative measurements correlated with tumor volume and with the disease course on serial sampling. Conclusions We demonstrated for the first time that the expression of e‐hTERT‐trans transcript can be measured in the serum of primary brain tumors. This exosomal marker carries the potential to serve as a biomarker once used in conjunction with other clinical and radiological parameters. Future studies are required to investigate whether the sensitivity could be augmented and whether it can be implemented into routine patients care