Hubungan Antara Identitas Sosial Dengan Perilaku Mengemudi Agresif Pada Komunitas Motor Rx-king Di Semarang

Identitas sosial merupakan penilaian positif atau negatif seseorang tentang siapa dirinya (termasuk di dalamnya adalah atribut pribadi dan atribut yang dibaginya bersama orang lain), berdasarkan keanggotaannya dalam suatu kelompok sosial seperti kelompok gender, ras, agama, dan kelompok sosial lainnya. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara identitas sosial dengan perilaku mengemudi agresif pada komunitas Rx-King di Semarang. Subjek penelitian adalah 100 orang anggota Club of Rx-King Semarang (CORS). Teknik pengambilan sampling dengan menggunakan convenience sampling. Pengumpulan data menggunakan Skala Identitas Sosial (29 aitem valid, α = 0,929) dan Skala Perilaku Mengemudi Agresif (31 aitem valid, α = 0,904). Berdasarkan hasil analisis regresi sederhana menunjukkan nilai koefisien korelasi rxy = 0,511 dengan p=0,000 (p<0,001). Hasil tersebut menunjukkan adanya hubungan positif yang signifikan antara identitas sosial dengan agressive driving pada komunitas motor rx-king Semarang. Artinya, semakin tinggi identitas sosial, maka semakin tinggi pula perilaku mengemudi agresif yang terlihat, begitupun sebaliknya. Identitas sosial memberikan sumbangan efektif sebesar 26,1% pada perilaku mengemudi agresif yang artinya perilaku mengemudi agresif tidak selalu terjadi karena identitas sosial masih ada faktor lain sebesar 73,9% yang tidak diukur dalam penelitian ini

Financial Performance, Audit Delay and Firm Values Banking in Indonesia

Fraud cases in capital market concerning financial report delay were the main issues ofthe research. The aim of this research was to investigate the effect of financial performance,audit delay, and firm value. Population of the research was all companies listedin Indonesian Stock Exchange, from 2011-2013. The total of research samples were 38banking companies with 97 annual reports done by using purposive sampling method.Data analyses used were classical assumption test and hypothesis test with multiplelinear regression analysis. The result of the research showed that financial performancehad a significant influence to audit delay, while financial performance had a significantinfluence to firm value. Meanwhile audit delay did not significantly influence to firmvalue. The practical implication of the research suggested the delay of the financial report\u27sdelivery had an impact toward company\u27s image in front of the stakeholders

Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring

Maternal obesity is known to increase the risk of obesity and diabetes in offspring. Though diabetes is a key risk factor for the development of chronic kidney disease (CKD), the relationship between maternal obesity and CKD has not been clearly defined. In this study, a mouse model of maternal obesity was employed to determine the impact of maternal obesity on development of diabetic nephropathy in offspring. Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow diet. At postnatal Week 8, offspring were randomly administered low dose streptozotocin (STZ, 55 mg/kg/day for five days) to induce diabetes. Assessment of renal damage took place at postnatal Week 32. We found that offspring of obese mothers had increased renal fibrosis, inflammation and oxidative stress. Importantly, offspring exposed to maternal obesity had increased susceptibility to renal damage when an additional insult, such as STZ-induced diabetes, was imposed. Specifically, renal inflammation and oxidative stress induced by diabetes was augmented by maternal obesity. Our findings suggest that developmental programming induced by maternal obesity has implications for renal health in offspring. Maternal obesity should be considered a risk factor for CKD

FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity

© 2015 Glastras et al. Background: Maternal obesity is associated with dysregulation of glucose and lipid metabolism with consequent exposure of the fetus to an abnormal metabolic milieu. It is recognized that maternal obesity predisposes offspring to chronic kidney disease (CKD). We aimed to determine whether the nuclear Farnesoid X receptor (FXR), known to play a role in maintaining homeostasis of glucose and lipid metabolism, is involved in renal injury in offspring of obese mothers. Methods: Maternal obesity was established in a rat model by feeding dams with high-fat diet prior to and during pregnancy and lactation. The offspring's kidneys were examined at postnatal Day 1and Day 20. Human kidney 2 (HK2) cells were exposed to high glucose with or without the FXR agonist GW4064 or when FXR mRNA was silenced. Results: Glucose intolerance in the offspring of obese mothers was evident at weaning, with associated downregulation of renal FXR expression and upregulation of monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor-β1 (TGF-β1). HK2 cells exposed to high glucose had reduced FXR expression and increased MCP-1, TGF-β1, fibronectin and collagen IV expression, which was reversed in the presence of GW4064. FXR-silenced HK2 cells had amplified pro-inflammatory and pro-fibrotic markers under high glucose conditions. Conclusions: Maternal obesity influences renal expression of pro-inflammatory and fibrotic factors that predispose the offspring to CKD. This was associated with the downregulation of the renal FXR expression suggesting a potential protective role for FXR

Impact of maternal cigarette smoke exposure on brain inflammation and oxidative stress in male mice offspring

Maternal cigarette smoke exposure (SE) during gestation can cause lifelong adverse effects in the offspring's brain. Several factors may contribute including inflammation, oxidative stress and hypoxia, whose changes in the developing brain are unknown. Female Balb/c mice were exposed to cigarette smoke prior to mating, during gestation and lactation. Male offspring were studied at postnatal day (P) 1, P20 and 13 weeks (W13). SE dams had reduced inflammatory mediators (IL-1β, IL-6 and toll like receptor (TLR)4 mRNA), antioxidant (manganese superoxide dismutase (MnSOD)), and increased mitochondrial activities (OXPHOS-I, III and V) and protein damage marker nitrotyrosine. Brain hypoxia-inducible factor (HIF)1α and its upstream signalling molecule early growth response factor (EGR)1 were not changed in the SE dams. In the SE offspring, brain IL-1R, IL-6 and TLR4 mRNA were increased at W13. The translocase of outer mitochondrial membrane, and MnSOD were reduced at W13 with higher nitrotyrosine staining. HIF-1α was also increased at W13, although EGR1 was only reduced at P1. In conclusion, maternal SE increased markers of hypoxia and oxidative stress with mitochondrial dysfunction and cell damage in both dams and offspring, and upregulated inflammatory markers in offspring, which may render SE dams and their offspring vulnerable to additional brain insults

Impact of maternal cigarette smoke exposure on brain and kidney health outcomes in female offspring

© 2016 John Wiley & Sons Australia, Ltd Increased oxidative stress in the brain can lead to increased sympathetic tone that may further induce kidney dysfunction. Previously we have shown that maternal cigarette smoke exposure (SE) leads to significantly increased oxidative stress and inflammation in both brain and kidney, as well as reduced brain and kidney mitochondrial activity. This is closely associated with significant kidney underdevelopment and abnormal function in adulthood in the male offspring. This study aimed to investigate the impact of maternal SE on brain and kidney health in the female offspring. In this study, the mouse dams were exposed to two cigarettes, twice daily for 6 weeks prior to gestation, during pregnancy and lactation. Brains and kidneys from the female offspring were collected at 20 days (P20) and 13 weeks (W13) and were subject to further analysis. We found that mRNA expression of brain inflammatory markers interleukin-1 receptor and Toll-like receptor 4 were significantly increased in the SE offspring at both P20 and W13. Their brain mitochondrial activity markers were however increased at W13 with increased antioxidant activity. Kidney development and function in the female SE offspring were not different from the control offspring. We concluded that although brain inflammatory markers were upregulated in the SE female offspring, they were protected from some of the indicators of brain oxidative stress, such as endogenous antioxidant and mitochondrial dysfunction, as well as abnormal kidney development and function in adulthood

IDENTIFIKASI POTENSI KERUSAKAN PADA BOTTOM OUTLET BENDUNGAN PASELLORENG

Bendungan Paselloreng yang terletak di Kabupaten Wajo Provinsi Sulawesi Selatan di impuonding pada tanggal 01 maret 2021 adalah bangunan sebagai pengendali banjir dan bangunan penyimpan air pada saat musim kering. Bendungan yang didesain dengan fasilitas bottom outlet. Salah satu permasalahan yang dijumpai di lapangan yaitu terkait bottom outlet. Saat pembahasan persiapan pengisian awal waduk, hasil sidang Pleno KKB (Komisi Keamanan Bendungan) merekomendasikan agar bendungan dilengkapi dengan fasilitas bottom outlet yang dibangun pada terowongan pengelak untuk mengantisipasi potensi-potensi rembesan, retakan dan penurunan. Kemudian setelah bendungan sudah beroperasi, bottom outlet direncanakan dapat difungsikan sebagai bangunan pengeluaran tambahan, pembilasan sedimen dan emergency outlet. Namun, hingga saat ini bottom outlet belum dapat difungsikan dengan optimal dikarenakan rumah bottom outlet belum selesai dibangun serta beberapa permasalahan lain. Permasalahan yang terjadi pada operasi bottom outlet umumnya disebabkan oleh kondisi aliran dengan kecepatan yang tinggi, seperti erosi, kerusakan akibat getaran, kavitasi dan disipasi energi yang kurang memadai

Melakukan Wasiat Yang Menyimpang Dalam Terminologi Fiqih Menurut Tokoh Nahdatul Ulama Dan Tokok Muhammadiyah (Studi Kasus Di Kecamatan Tanjung Medan Kabupaten Rokan Hilir)

Allah mensyariatkan bahwa wasiat mengandung hikmah yang besar bagi hambahambaNya, yaitu merupakan salah satu cara yang dipergunakan manusia untuk mendekatkan diri kepada Allah serta untuk menambah amal baik dari kemaslahatan manusia di dunia dan di akhirat. Dalam hukum adat, wasiat adalah pemberian yang dilaksanakan oleh seorang kepada ahli warisnya atau orang tertentu yang pelaksanaannya dilakukan setelah orang yang menyatakan wasiat itu meninggal. Wasiat dibuat karena berbagai alasan yang biasanya adalah untuk menghindarkan persengketaan atau mengurangi beban si pewasiat ketika ia meninggal dunia, perwujudan rasa kasih sayang dari orang yang menyatakan wasiat Oleh karena itu, didalam wasiat terdapat kebaikan dan pertolongan kepada manusia. Sebab dengan wasiat seseorang dapat berbuat baik dan berlaku adil kepada orang lain dan kerabatnya. Ulama fiqih juga menyebutkan bahwa wasiat merupakan suatu penyerahan sesuatu yang bisa bermanfaat secara sukarela dari seseorang kepada pihak lain yang berlaku setelah orang tersebut wafat. Wasiat tersebut sekalipun akadnya dibuat ketika orang yang berwasiat masih hidup, tetap hukumnya baru berlaku ketika orang yang berwasiat itu wafat. wasiat yang terjadi di kecamatan Tanjung Medan Kabupaten Rokan Hilir dimana masyarakatnya melakukan wasiat tersebut, tidak sesuai dengan apa yang di ajarkan dalam Islam, serta dalam hukumhukum fiqih lainnya. Berdasarkan wasiat yang dilakukan di kecamatan Tanjung Medan Kabupaten Rokan Hilir tersebut. Wasiat yang dilakukan masyarakat tersebut berupa permintaan untuk dipotong jarinya ketika ia sudah m eninggal dunia, dan wasiat itu pun dilakukan secara turuntemurun. wasiat yang menyimpang seperti wasiat mengambilan organ tubuh, Pada muktamar Muhammadiyah 32 di Yogyakarta tahun 1990 perbuatan tersebut dibolehkan, sedangkan pada Mukhtamar nahdlatul ulama 38 tanggal 25-28 nopember 1989 M di pondok pesantren al-munawwir krapyak Yogyakarta, yang berisikan bahwa perbuatan tersebut tidak sah atau batal