2,184 research outputs found
Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide
Impact of Pay for Performance on Prescribing of Long-Acting Reversible Contraception in Primary Care: An Interrupted Time Series Study
BACKGROUND: The aim of this study was to evaluate the impact of Quality and Outcomes Framework (QOF), a major pay-for-performance programme in the United Kingdom, on prescribing of long-acting reversible contraceptives (LARC) in primary care. METHODS: Negative binomial interrupted time series analysis using practice level prescribing data from April 2007 to March 2012. The main outcome measure was the prescribing rate of long-acting reversible contraceptives (LARC), including hormonal and non hormonal intrauterine devices and systems (IUDs and IUSs), injectable contraceptives and hormonal implants. RESULTS: Prescribing rates of Long-Acting Reversible Contraception (LARC) were stable before the introduction of contraceptive targets to the QOF and increased afterwards by 4% annually (rate ratios = 1.04, 95% CI = 1.03, 1.06). The increase in LARC prescribing was mainly driven by increases in injectables (increased by 6% annually), which was the most commonly prescribed LARC method. Of other types of LARC, the QOF indicator was associated with a step increase of 20% in implant prescribing (RR = 1.20, 95% CI = 1.09, 1.32). This change is equivalent to an additional 110 thousand women being prescribed with LARC had QOF points not been introduced. CONCLUSIONS: Pay for performance incentives for contraceptive counselling in primary care with women seeking contraceptive advice has increased uptake of LARC methods
Dependence of Maximum Trappable Field on Superconducting Nb3Sn Cylinder Wall Thickness
Uniform dipole magnetic fields from 1.9 to 22.4 kOe were permanently trapped,
with high fidelity to the original field, transversely to the axes of hollow
Nb3Sn superconducting cylinders. These cylinders were constructed by helically
wrapping multiple layers of superconducting ribbon around a mandrel. This is
the highest field yet trapped, the first time trapping has been reported in
such helically wound taped cylinders, and the first time the maximum trappable
field has been experimentally determined as a function of cylinder wall
thickness.Comment: 8 pages, 4 figures, 1 table. PACS numbers: 74.60.Ge, 74.70.Ps,
41.10.Fs, 85.25.+
Global gravitational instability of FLRW backgrounds - interpreting the dark sectors
The standard model of cosmology is based on homogeneous-isotropic solutions
of Einstein's equations. These solutions are known to be gravitationally
unstable to local inhomogeneous perturbations, commonly described as evolving
on a background given by the same solutions. In this picture, the FLRW
backgrounds are taken to describe the average over inhomogeneous perturbations
for all times. We study in the present article the (in)stability of FLRW dust
backgrounds within a class of averaged inhomogeneous cosmologies. We examine
the phase portraits of the latter, discuss their fixed points and orbital
structure and provide detailed illustrations. We show that FLRW cosmologies are
unstable in some relevant cases: averaged models are driven away from them
through structure formation and accelerated expansion. We find support for the
proposal that the dark components of the FLRW framework may be associated to
these instability sectors. Our conclusion is that FLRW cosmologies have to be
considered critically as for their role to serve as reliable models for the
physical background.Comment: 15 pages, 13 figures, 1 table. Matches published version in CQ
Ergodicity criteria for non-expanding transformations of 2-adic spheres
In the paper, we obtain necessary and sufficient conditions for ergodicity
(with respect to the normalized Haar measure) of discrete dynamical systems
on 2-adic spheres of radius
, , centered at some point from the ultrametric space of
2-adic integers . The map is
assumed to be non-expanding and measure-preserving; that is, satisfies a
Lipschitz condition with a constant 1 with respect to the 2-adic metric, and
preserves a natural probability measure on , the Haar measure
on which is normalized so that
Surface critical behavior of bcc binary alloys
The surface critical behavior of bcc binary alloys undergoing a continuous
B2-A2 order-disorder transition is investigated in the mean-field (MF)
approximation. Our main aim is to provide clear evidence for the fact that
surfaces which break the two-sublattice symmetry generically display the
critical behavior of the NORMAL transition, whereas symmetry-preserving
surfaces exhibit ORDINARY surface critical behavior. To this end we analyze the
lattice MF equations for both types of surfaces in terms of nonlinear
symplectic maps and derive a Ginzburg-Landau model for the symmetry-breaking
(100) surface. The crucial feature of the continuum model is the emergence of
an EFFECTIVE ORDERING (``staggered'') SURFACE FIELD, which depends on
temperature and the other lattice model parameters, and which explains the
appearance of NORMAL critical behavior for symmetry-breaking surfaces.Comment: 16 pages, REVTeX 3.0, 13 EPSF figures, submitted to Phys. Rev.
Evolution of the Bianchi I, the Bianchi III and the Kantowski-Sachs Universe: Isotropization and Inflation
We study the Einstein-Klein-Gordon equations for a convex positive potential
in a Bianchi I, a Bianchi III and a Kantowski-Sachs universe. After analysing
the inherent properties of the system of differential equations, the study of
the asymptotic behaviors of the solutions and their stability is done for an
exponential potential. The results are compared with those of Burd and Barrow.
In contrast with their results, we show that for the BI case isotropy can be
reached without inflation and we find new critical points which lead to new
exact solutions. On the other hand we recover the result of Burd and Barrow
that if inflation occurs then isotropy is always reached. The numerical
integration is also done and all the asymptotical behaviors are confirmed.Comment: 22 pages, 12 figures, Self-consistent Latex2e File. To be published
in Phys. Rev.
A Study Of A New Class Of Discrete Nonlinear Schroedinger Equations
A new class of 1D discrete nonlinear Schrdinger Hamiltonians
with tunable nonlinerities is introduced, which includes the integrable
Ablowitz-Ladik system as a limit. A new subset of equations, which are derived
from these Hamiltonians using a generalized definition of Poisson brackets, and
collectively refered to as the N-AL equation, is studied. The symmetry
properties of the equation are discussed. These equations are shown to possess
propagating localized solutions, having the continuous translational symmetry
of the one-soliton solution of the Ablowitz-Ladik nonlinear
Schrdinger equation. The N-AL systems are shown to be suitable
to study the combined effect of the dynamical imbalance of nonlinearity and
dispersion and the Peierls-Nabarro potential, arising from the lattice
discreteness, on the propagating solitary wave like profiles. A perturbative
analysis shows that the N-AL systems can have discrete breather solutions, due
to the presence of saddle center bifurcations in phase portraits. The
unstaggered localized states are shown to have positive effective mass. On the
other hand, large width but small amplitude staggered localized states have
negative effective mass. The collison dynamics of two colliding solitary wave
profiles are studied numerically. Notwithstanding colliding solitary wave
profiles are seen to exhibit nontrivial nonsolitonic interactions, certain
universal features are observed in the collison dynamics. Future scopes of this
work and possible applications of the N-AL systems are discussed.Comment: 17 pages, 15 figures, revtex4, xmgr, gn
Two Bessel Bridges Conditioned Never to Collide, Double Dirichlet Series, and Jacobi Theta Function
It is known that the moments of the maximum value of a one-dimensional
conditional Brownian motion, the three-dimensional Bessel bridge with duration
1 started from the origin, are expressed using the Riemann zeta function. We
consider a system of two Bessel bridges, in which noncolliding condition is
imposed. We show that the moments of the maximum value is then expressed using
the double Dirichlet series, or using the integrals of products of the Jacobi
theta functions and its derivatives. Since the present system will be provided
as a diffusion scaling limit of a version of vicious walker model, the ensemble
of 2-watermelons with a wall, the dominant terms in long-time asymptotics of
moments of height of 2-watermelons are completely determined. For the height of
2-watermelons with a wall, the average value was recently studied by Fulmek by
a method of enumerative combinatorics.Comment: v2: LaTeX, 19 pages, 2 figures, minor corrections made for
publication in J. Stat. Phy
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