Plasma Concentrations of Tranexamic Acid in Postpartum Women After Oral Administration.

OBJECTIVE: To evaluate the pharmacokinetics of tranexamic acid after oral administration to postpartum women. METHODS: We conducted a single-center pharmacokinetic study at Teaching Hospital-Jaffna, Sri Lanka, on 12 healthy postpartum women who delivered vaginally. After oral administration of 2 g of immediate-release tranexamic acid 1 hour after delivery, pharmacokinetic parameters were measured on plasma samples at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, and 12 hours. Plasma tranexamic acid concentrations were determined by high-performance liquid chromatography. The outcome measures were maximum observed plasma concentration, time to maximum plasma concentration, time to reach effective plasma concentration, time period effective serum concentration lasted, area under the curve for drug concentration, and half-life of tranexamic acid. RESULTS: The mean maximum observed plasma concentration was 10.06 micrograms/mL (range 8.56-12.22 micrograms/mL). The mean time to maximum plasma concentration was 2.92 hours (range 2.5-3.5 hours). Mean time taken to reach the effective plasma concentration of 5 micrograms/mL and the mean time this concentration lasted were 0.87 hours and 6.73 hours, respectively. Duration for which plasma tranexamic acid concentration remained greater than 5 micrograms/mL was 5.86 hours. Half-life was 1.65 hours. Area under the curve for drug concentration was 49.16 micrograms.h/mL (range 43.75-52.69 micrograms.h/mL). CONCLUSION: Clinically effective plasma concentrations of tranexamic acid in postpartum women may be achieved within 1 hour of oral administration. Given the promising pharmacokinetic properties, we recommend additional studies with larger sample sizes to investigate the potential of oral tranexamic acid for the treatment or prophylaxis of postpartum hemorrhage

रजत कोंगर सर्पमीन के वायूआशय का चेन्नई से निर्यात

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Some recent observations on small-scale fishery In the vicinity of Madras

Madras zone is one of the important fishing centres on the east coast of India. To understand the fish landings from different gears in Madras, three landing centres, viz., Kasimedu, Triplicane and Nochikuppam were selected. Kasimedu is about 8 km north of Triplicane and Nochikuppam is about 2 km south of Triplicane. The major catch components from the demersal trawls of this area arc silver bellies, threadfin breams, sciaenids, lizardfish, prawns, squids and cuttlefish. These groups are landed in a meagre quantity by the traditional gears, thus maintaining compatability between mechanised and non-mechanised gears in the exploitation of fishery resources off Madras

चेन्नई मात्स्यिकी पोताश्रय में बैग जाल द्वारा बोई (मल्लेट) मुजिल सेफेलस का भारी अवतरण

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A Research on Wireless Power Transmission using Distinguished Methodologies

Flat screen TV’s and picture frames that suspend on the wall-without needing a cable and plug up for power. Industrial structures and medical machines can be made more trustworthy by eradicating difficulty prone wiring and disposable batteries. The method takes the advantage of straightforward physics and could be used to indict a variety of electronic tools over numerous meters. The arrangement could substitute the miles of costly power cables and billions of throw-away batteries. There is rather like 40 billion throw-away batteries built each year for power that is employed within a petite inches or feet of where there is extremely low-cost power. If this knowledge is acknowledged in prospect it will make daily products additional expedient, consistent, and environmentally welcoming. This document includes the methods of transmitting power with no usage of wires with improved efficiency, due to which it does not influence the atmospheric surrounding

Bio-Medical Application of Wireless Power Transmission System

This paper presents the wireless power transmission system is separated into three main components, the transceiver, the inductive coils and the RF/DC converter. Simple examines were done to check the model and simulations were done to display the benefit of wireless power transmission which also avoids accidents related to large wires and no adequate grounding. To increase the quality of diagnosis, some main specifications such as image resolution, frame rate and working time need to be developed. Moreover, future multi-functioning robotic capsule endoscopy units may consume advanced features such as energetic system control over capsule motion, drug delivery systems, semi-surgical tools and biopsy. However, the addition of the above innovative features demands extrapower that makes conventional power source methods are difficult. In this regards, wireless power transmission system has received attention among researchers to overcome this problem. This paper defines the reviews on techniques of using wireless power transmission for bio-medical applications

On the Effect of Rigid Swept Surface Waves on Turbulent Drag

Passive turbulent drag reduction techniques are of interest as a cost effective means to improve air vehicle fuel consumption. In the past, rigid surface waves slanted at an angle from the streamwise direction were deemed ineffective to reduce skin friction drag due to the pressure drag that they generate. A recent analysis seeking similarities to the spanwise shear stress generated by spatial Stokes layers suggested that there may be a range of wavelength, amplitude, and orientation in which the wavy surface would reduce turbulent drag. The present work explores, by experiments and Direct Numerical Simulations (DNS), the effect of swept wavy surfaces on skin friction and pressure drag. Plates with shallow and deep wave patterns were rapid-prototyped and tested using a drag balance in the 7x11 inch Low-Speed Wind Tunnel at the NASA LaRC Research Center. The measured drag o set between the wavy plates and the reference at plate is found to be within the experimental repeatability limit. Oil vapor flow measurements indicate a mean spanwise flow over the deep waves. The turbulent flow in channels with at walls, swept wavy walls and spatial Stokes spanwise velocity forcing was simulated at a friction Reynolds number of two hundred. The time-averaged and dynamic turbulent flow characteristics of the three channel types are compared. The drag obtained for the channel with shallow waves is slightly larger than for the at channel, within the range of the experiments. In the case of the large waves, the simulation over predicts the drag. The shortcomings of the Stokes layer analogy model for the estimation of the spanwise shear stress and drag are discussed

Measurements in a Transitioning Cone Boundary Layer at Freestream Mach 3.5

An experimental study was conducted in the Supersonic Low-Disturbance Tunnel to investigate naturally-occurring instabilities in a supersonic boundary layer on a 7 deg half- angle cone. All tests were conducted with a nominal freestream Mach number of M(sub infinity) = 3:5, total temperature of T(sub 0) = 299:8 K, and unit Reynolds numbers of Re(sub infinity) x 10(exp -6) = 9:89, 13.85, 21.77, and 25.73 m(exp -1). Instability measurements were acquired under noisy- ow and quiet- ow conditions. Measurements were made to document the freestream and the boundary-layer edge environment, to document the cone baseline flow, and to establish the stability characteristics of the transitioning flow. Pitot pressure and hot-wire boundary- layer measurements were obtained using a model-integrated traverse system. All hot- wire results were single-point measurements and were acquired with a sensor calibrated to mass ux. For the noisy-flow conditions, excellent agreement for the growth rates and mode shapes was achieved between the measured results and linear stability theory (LST). The corresponding N factor at transition from LST is N 3:9. The stability measurements for the quiet-flow conditions were limited to the aft end of the cone. The most unstable first-mode instabilities as predicted by LST were successfully measured, but this unstable first mode was not the dominant instability measured in the boundary layer. Instead, the dominant instabilities were found to be the less-amplified, low-frequency disturbances predicted by linear stability theory, and these instabilities grew according to linear theory. These low-frequency unstable disturbances were initiated by freestream acoustic disturbances through a receptivity process that is believed to occur near the branch I locations of the cone. Under quiet-flow conditions, the boundary layer remained laminar up to the last measurement station for the largest Re1, implying a transition N factor of N greater than 8:5

Embolic strokes of undetermined source: prevalence and patient features in the ESUS Global Registry

Background: Recent evidence supports that most non-lacunar cryptogenic strokes are embolic. Accordingly, these strokes have been designated as embolic strokes of undetermined source (ESUS). Aims: We undertook an international survey to characterize the frequency and clinical features of ESUS patients across global regions. Methods: Consecutive patients hospitalized for ischemic stroke were retrospectively surveyed from 19 stroke research centers in 19 different countries to collect patients meeting criteria for ESUS. Results: Of 2144 patients with recent ischemic stroke, 351 (16%, 95% CI 15% to 18%) met ESUS criteria, similar across global regions (range 16% to 21%), and an additional 308 (14%) patients had incomplete evaluation required for ESUS diagnosis. The mean age of ESUS patients (62 years; SD = 15) was significantly lower than the 1793 non-ESUS ischemic stroke patients (68 years, p ≤ 0.001). Excluding patients with atrial fibrillation (n = 590, mean age = 75 years), the mean age of the remaining 1203 non-ESUS ischemic stroke patients was 64 years (p = 0.02 vs. ESUS patients). Among ESUS patients, hypertension, diabetes, and prior stroke were present in 64%, 25%, and 17%, respectively. Median NIHSS score was 4 (interquartile range 2–8). At discharge, 90% of ESUS patients received antiplatelet therapy and 7% received anticoagulation. Conclusions: This cross-sectional global sample of patients with recent ischemic stroke shows that one-sixth met criteria for ESUS, with additional ESUS patients likely among those with incomplete diagnostic investigation. ESUS patients were relatively young with mild strokes. Antiplatelet therapy was the standard antithrombotic therapy for secondary stroke prevention in all global regions

Data Deduplication in A Blockchain-Enabled Big Data Ecosystem: Secure and Efficient Cloud Storage

To get around the limits of local storage and ensure that data can be accessed from anywhere at any time, cloud storage services have become very important. Data compression technology helps save bandwidth and disk space. Removing extra data from cloud storage can save up to 95% of room. Despite recent improvements in cloud storage, there are still security and privacy concerns. This piece discusses the security and privacy concerns related to big data and outlines the basic requirements that future solutions should address. This paper aims to introduce a new technology strategy for handling and controlling security and privacy risks related to big data. This paper uses a design science study method. The proposed system uses Blockchain technology to securely store large amounts of data by managing its information and rules and keeping outside parties out protecting data security and privacy. This method uses very little computing power to create file encryption keys. Tests and security checks show that it keeps the keys safe and protects the data\u27s privacy. Computational speed improves because it takes less than 2 seconds to create encryption keys, even for a 500 MB file. We show a working model of our proposed system in a real-life data store scenario using the Ethereum Blockchain. The review and research show that our proposed framework provides a useful method for safely storing data in a Big Data environment