Parity Nonconservation in Neutron Resonances in 133Cs

Spatial parity nonconservation (PNC) has been studied in the compound-nuclear states of 134Cs by measuring the helicity dependence of the neutron total cross section. Transmission measurements on a thick 133Cs target were performed by the time-of-flight method at the Manuel Lujan Neutron Scattering Center with a longitudinally polarized neutron beam in the energy range from 5 to 400 eV. A total of 28 new p-wave resonances were found, their neutron widths determined, and the PNC longitudinal asymmetries of the resonance cross sections measured. The value obtained for the root-mean-square PNC element M=(0.06-0.02+0.25) meV in 133Cs is the smallest among all targets studied. This value corresponds to a weak spreading width Γw=(0.006-0.003+0.154)×10-7 eV

Analysis of fractures in volcanic cores from Pahute Mesa, Nevada Test Site

The Nevada Test Site (NTS), located in Nye County, southern Nevada, was the location of 828 announced underground nuclear tests, conducted between 1951 and 1992. Approximately one-third of these tests were detonated near or below the water table. An unavoidable consequence of these testing activities was introducing radionuclides into the subsurface environment, impacting groundwater. Groundwater flows beneath the NTS almost exclusively through interconnected natural fractures in carbonate and volcanic rocks. Information about these fractures is necessary to determine hydrologic parameters for future Corrective Action Unit (CAU)-specific flow and transport models which will be used to support risk assessment calculations for the U.S. Department of Energy, Nevada Operations Office (DOE/NV) Underground Test Area (UGTA) remedial investigation. Fracture data are critical in reducing the uncertainty of the predictive capabilities of CAU-specific models because of their usefulness in generating hydraulic conductivity values and dispersion characteristics used in transport modeling. Specifically, fracture aperture and density (spacing) are needed to calculate the permeability anisotropy of the formations. Fracture mineralogy information is used qualitatively to evaluate diffusion and radionuclide retardation potential in transport modeling. All these data can best be collected through examination of core samples

Manual mapping of drumlins in synthetic landscapes to assess operator effectiveness

Mapped topographic features are important for understanding processes that sculpt the Earth's surface. This paper presents maps that are the primary product of an exercise that brought together 27 researchers with an interest in landform mapping wherein the efficacy and causes of variation in mapping were tested using novel synthetic DEMs containing drumlins. The variation between interpreters (e.g. mapping philosophy, experience) and across the study region (e.g. woodland prevalence) opens these factors up to assessment. A priori known answers in the synthetics increase the number and strength of conclusions that may be drawn with respect to a traditional comparative study. Initial results suggest that overall detection rates are relatively low (34–40%), but reliability of mapping is higher (72–86%). The maps form a reference dataset

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume

The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-β PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-β positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimer’s disease-related phenotypes, including measures of cognition or brain Amyloid-β burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes

Efficient and formal generalized symbolic execution

Programs that manipulate dynamic heap objects are difficult to analyze due to issues like aliasing. Lazy initialization algorithm enables the classical symbolic execution to handle such programs. Despite its successes, there are two unresolved issues: (1) inefficiency; (2) lack of formal study. For the inefficiency issue, we have proposed two improved algorithms that give significant analysis time reduction over the original lazy initialization algorithm. In this article, we formalize the lazy initialization algorithm and the improved algorithms as operational semantics of a core subset of the Java Virtual Machine (JVM) instructions, and prove that all algorithms are relatively sound and complete with respect to the JVM concrete semantics. Finally, we conduct a set of extensive experiments that compare the three algorithms and demonstrate the efficiency of the improved algorithms