17 research outputs found
Assessment and validation of a microinjection method for kinetic analysis of [Ca2+]i in individual cells undergoing apoptosis
No full text508 STEROIDOGENIC PROPERTIES OF PROSTATE CANCER CELL-LINES: PROOF FOR INTRACRINE ANDROGEN METABOLISM?
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Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer
No full text434 Bipolar androgen therapy for men with castration sensitive and castration resistant prostate cancer: Reversing resistance and maintaining sensitivity to androgen ablative therapies
Full text linkNatural Products as Starting Materials for Development of Second Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells
No full textAn analysis of the binding of the 8 O N tert butoxycarbonyl 12 aminododecanoyl derivative of 8 O debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O 8. Based on the analysis a series of analogues to the 2 unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12 Boc aminododecaonoyl derivative, however, was found to be apoptoti
Crystal structures of SERCA in complex with inhibitors with potential as prostate cancer drugs
Full text linkAr-V7 Splice Variant and Resistance to Enzalutamide and Abiraterone in Men with Metastatic Castration-Resistant Prostate Cancer (Mcrpc): Overall Survival Results
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