Clinical and regulatory development strategies for GBS vaccines intended for maternal immunisation in low- and middle-income countries

Group B Streptococcus (GBS) is a leading cause of infant mortality, particularly in low- and middle-income countries (LMICs). Several maternal GBS vaccine candidates, aimed at protecting infants, are progressing through clinical trials. The World Health Organisation (WHO) aims to ensure equitable access to safe, effective, and affordable vaccines of assured quality in LMICs, by facilitating regulatory pathways. An alternate approval pathway, based on safety and an immunological endpoint thought to predict clinical benefit (commonly referred to as serological threshold of risk reduction [SToRR]), is being considered for GBS maternal vaccines. Since this approach is new to many LMICs regulators and policymakers, WHO organized consultative meetings at national, regional, and global levels to discuss the feasibility and potential challenges of approving a GBS vaccine based on safety and immunogenicity data alone. These consultations focused on evidence supporting SToRR, their use as endpoints to infer protection, and post-licensure requirements. The aim of the consultations was to reduce the delay between vaccine development, licensure, policy recommendations and use in high-burden LMICs

Complexity absorption : A processual strategic approach to corporate entrepreneurship strategy

The author Haina Zhang acknowledges the support of research grant received from the Lancaster University Research Committee (award reference: SGS21/33). The author is also grateful to Professor David Brown for his suggestions on earlier version of this paper.Peer reviewedPublisher PD

Comparing the effectiveness of hyperspectral imaging and Raman spectroscopy:A case study on Armenian manuscripts

There is great practical and scholarly interest in the identification of pigments in works of art. This paper compares the effectiveness of the widely used Raman Spectroscopy (RS), with hyperspectral imaging (HSI), a reflectance imaging technique, to evaluate the reliability of HSI for the identification of pigments in historic works of art and to ascertain if there are any benefits from using HSI or a combination of both. We undertook a case study based on six Armenian illuminated manuscripts (eleventh–eighteenth centuries CE) in the Bodleian Library, University of Oxford. RS, and HSI (380–1000 nm) were both used to analyse the same 10 folios, with the data then used to test the accuracy and efficiency of HSI against the known results from RS using reflectance spectra reference databases compiled by us for the project. HSI over the wavelength range 380–1000 nm agreed with RS at best 93% of the time, and performance was enhanced using the SFF algorithm and by using a database with many similarities to the articles under analysis. HSI is significantly quicker at scanning large areas, and can be used alongside RS to identify and map large areas of pigment more efficiently than RS alone. HSI therefore has potential for improving the speed of pigment identification across manuscript folios and artwork but must be used in conjunction with a technique such as RS

The response of tropical rainforests to drought : lessons from recent research and future prospects

Key message: we review the recent findings on the influence of drought on tree mortality, growth or ecosystem functioning in tropical rainforests. Drought plays a major role in shaping tropical rainforests and the response mechanisms are highly diverse and complex. The numerous gaps identified here require the international scientific community to combine efforts in order to conduct comprehensive studies in tropical rainforests on the three continents. These results are essential to simulate the future of these ecosystems under diverse climate scenarios and to predict the future of the global earth carbon balance. - Context: tropical rainforest ecosystems are characterized by high annual rainfall. Nevertheless, rainfall regularly fluctuates during the year and seasonal soil droughts do occur. Over the past decades, a number of extreme droughts have hit tropical rainforests, not only in Amazonia but also in Asia and Africa. The influence of drought events on tree mortality and growth or on ecosystem functioning (carbon and water fluxes) in tropical rainforest ecosystems has been studied intensively, but the response mechanisms are complex.- Aims: herein, we review the recent findings related to the response of tropical forest ecosystems to seasonal and extreme droughts and the current knowledge about the future of these ecosystems. - Results: this review emphasizes the progress made over recent years and the importance of the studies conducted under extreme drought conditions or in through-fall exclusion experiments in understanding the response of these ecosystems. It also points to the great diversity and complexity of the response of tropical rainforest ecosystems to drought. - Conclusion: the numerous gaps identified here require the international scientific community to combine efforts in order to conduct comprehensive studies in tropical forest regions. These results are essential to simulate the future of these ecosystems under diverse climate scenarios and to predict the future of the global earth carbon balance

Digital Technology to Enhance Project Leadership Practice: The Case of Civil Construction

Digital transformation is fundamentally influencing all aspects of business and society. It can enable individuals and organizations to transcend from one way of working to another. In construction, emphasis is shifting from project management to project leadership, as professionals need assisting tools to not only aid in managing tasks and activities, but aid in leading people. As such, the adoption of digital technologies may hold the key in taking project leadership practice into the future. To date, there have been few attempts to explore the potential of digital technology as an aid for project leadership development and practice. This research therefore aims to investigate this potential in the context of the Australian civil construction industry. We review the existing body of knowledge on both industry-specific leadership demands and relevant digital technology capabilities to identify areas of improvement and to guide interviews with construction project managers. So far, literature has focused on endorsing particular leadership behaviors and/or styles, while ignoring the difficulties faced by professionals in practicing these behaviors. We find that project managers of civil contractors within Sydney understand the significance of leadership but are often overwhelmed by its complexity

Wave data assimilation using a hybrid approach in the Persian Gulf

The main goal of this study is to develop an efficient approach for the assimilation of the hindcasted wave parameters in the Persian Gulf. Hence, the third generation SWAN model was employed for wave modeling forced by the 6-h ECMWF wind data with a resolution of 0.5஠In situ wave measurements at two stations were utilized to evaluate the assimilation approaches. It was found that since the model errors are not the same for wave height and period, adaptation of model parameter does not result in simultaneous and comprehensive improvement of them. Therefore, an approach based on the error prediction and updating of output variables was employed to modify wave height and period. In this approach, artificial neural networks (ANNs) were used to estimate the deviations between the simulated and measured wave parameters. The results showed that updating of output variables leads to significant improvement in a wide range of the predicted wave characteristics. It was revealed that the best input parameters for error prediction networks are mean wind speed, mean wind direction, wind duration, and the wave parameters. In addition, combination of the ANN estimated error with numerically modeled wave parameters leads to further improvement in the predicted wave parameters in contrast to direct estimation of the parameters by ANN.Full Tex