MicroRNA and vascular pathology of the eye

Since the discovery of microRNAs just a few decades ago, our knowledge of these molecules and their potential as diagnostic biomarkers and therapeutic targets has significantly expanded. There is an ongoing discussion in the scientific community about the possibility of using microRNA for the diagnosis of cardiovascular diseases. It has been shown recently that levels of some microRNAs vary in vascular eye disorders, such as age-related macular degeneration and diabetic retinopathy. However, despite serious advances in our understanding of microRNA’s role in eye pathology, we still do not know whether it is possible to use microRNA as a biomarker for central retinal vein occlusion. Perhaps, the discovery of such candidate microRNAs will help in making the timely diagnosis and improve the quality of medical care in patients with retinal vein occlusion.</jats:p

Energy-saving technologies in design and construction of residential buildings and industrial facilities in the far North

The article discusses the main problems of energy saving and special features of design, construction and operation of residential buildings and industrial structures in extreme climatic conditions of the Northern territories. The impact of permafrost, seasonal thawing of soils and low bearing capacity of thawed soils on the choice of ways of arrangement of cities and pipelines in the Northern regions of Russia have been analyzed. There have been assessed the effect of climate change and the associated natural and man-made risks in the Far North on the development of a system of measures to ensure the reliability of energy facilities and options for emergency response. The solutions allowing to increase energy-saving capabilities of buildings and to reduce expenditures at their operation have been designated. Necessity of using non-traditional and renewable energy sources has been considered

The Mechanisms of Action of Cationic Antimicrobial Peptides Refined by Novel Concepts from Biophysical Investigations

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