Site-specific DNA oxidation by a dinuclear copper complex containing a photoisomerizable azobenzene ligand

A dinuclear copper complex possessing an azobenzene backbone (Cu^[II]_[2]1) was synthesized and its affinity towards DNA was investigated and found to be dependent on the trans–cis isomeric forms. Upon exposure to UV light at 365 nm the trans form of the complex (Cu^[II]_[2]trans-1) underwent photoisomerization into the cis-isomer (Cu^[II]_[2]cis-1), which reverted to the original trans-form on exposure to visible light at 420 nm. Both thetrans and cis isomers exhibited moderate DNA cleavage activity toward plasmid duplex DNA in the presence of a reducing agent 3-mercaptopropionic acid (MPA) suggesting that the Cu^[I] species could activate molecular oxygen to form a reactive oxygen species in situ. Interestingly, the isomeric copper complexes showed different site-specificities in the oxidation of an oligodeoxynucleotide having single-strand–double-helix junctions in the sequence. The trans isomer Cu^[I]_[2]trans-1 induced oxidation at the consecutive deoxyguanosine site (GG) near the junction; on the other hand, such site-specificity was not observed in the case of Cu^[I]_[2]cis-1

NetSec: Real-time and Scalable Malware Traffic Detection within IoT Networks

Detecting malicious network traffic in real time has become a crucial requirement at smart communities for elderly care and medical facilities with the prevalence of Internet-of-things (IoT) devices. Existing machine learning based solutions for network traffic malware detection often fail to scale with the exponential increase of IoT devices at the facility and to detect malicious traffic with desirable low latency. In this paper we seek to fill the gap by designing a scalable end-to-end network traffic analyzing system that permits real-time malware detection. By leveraging distributed systems such as Apache Kafka and Apache Spark, the system has demonstrated scalable performance as the number of IoT devices grow. Using Intel’s oneAPI software stack for both machine learning and deep learning models, the model inference speed is boosted by three-fold

Interrelationship of Jatharagni and Dhatvagni in context to Dhatvagni Pradoshaj Vikaras

The concept of Agni is basic concept of Ayurveda. Agni is believed to be the agency for any kind of transformation. Maharshi Vagbhatta says that each of the Dosha, Dhatu, Mala etc. have their own Agni. This is how the number of Agni cannot be limited. Though each and every Agni has its own importance, Dehagni or Jatharagni is the most important one as all other Agnis are depended upon Dehagni. Acharya Vagbhatta says that proper function of every Dhatvagni is depended on the Jatharagni. Increase or decrease of Jatharagni directly affects the function of Dhatvagni. Thus, Maharshi Charaka established functional relationship among Jatharagni and other Agnis. Maharshi Vagbhattta goes one step ahead of Maharshi Charaka by using word “Amsha” means; moieties of Kayagni, located to in its own place, are distributed to and permeate to all the Dhatus. A decrease of it (below the normal) makes for an increase of the Dhatus, while an increase of it (above the normal) makes for a decrease of a Dhatus. This shows structural relationship too, between Jatharagni and Dhatvagni as “Amsha” always indicates Murtatva or material form. Further more all these Agnis are connected with each other and due to this relationship, vitiation of Jatharagni results in vitiation of all the other Agnis

Importance of Poorvakarmas in Shodhana therapy - A Revi

In recent era Panchakarma has got prominent place in the management of the diseases through Ayurveda, because Panchakarma is only hope in patients who are bushed after all the Shamana treatments. Panchakarma expels the Doshas from their causative roots so diseases cannot revert after; like tree cannot grow without its root. Without proper Poorvakarma physician cannot get truly result though Shodhana procedure (like Vamana/Virechana) performed well, because without Poorvakarmas Doshas cannot be changed in particular forms through which they can be expelled out from the body. The present paper is focused on explanation of the principle that how Poorvakarma is essential for Shodhana therapy, how they change Dosha’s form and elucidate the Kala and Matra of Poorvakarma particular in Snehapana

Role of Yoga in gastro-intestinal problems w.s.r. to Constipation (Vibandha) in geriatrics

Jararoga can be incorporated in geriatrics in modern parlance which is a branch of medicine concerned especially with problems of ageing and diseases of elderly people. It tends to vary in different age groups by genetic factors, dietary habits, socio-economically conditions, life style, occurrence of diseases etc. Ayurveda has considered aged or elderly as Jara or Vardhakya, a natural disease. During this period of life, due to Dhatukshaya, Vatavriddhi etc., Vatika disorders related to Gastro-intestinal tract like indigestion, abdominal distention, flatulence, diarrhoea, joint pain, backache, tremors in limbs, Insomnia are common problems. Among these constipation (Vibandha) is commonly complained by every second elder person. So, to treat this problem completely various Yogic procedures which are economically almost free can be a good alternative to treat constipation holistically. Management of geriatric G.I.T. problems especially constipation by Yoga can be done in two ways, by Yogic Ahara and by Yogic Vihara as Acharya Charaka says “Ahara Sambhavam Vastu Roga Aahar Sambhava”. Yogic Vihara means by various Yogic Kriyas and Asanas like Surya-namaskar, Vajrasana, Pashchimothasana, Dhanurasana, Pranayama, Pratyahara and various Agnisara Kriyas through one can get control over Apana Vayu by correcting Jatharagni successfully

Lived experiences of nurses caring for adolescents with mental health problems in a psychiatric hospital in the Western Cape Province

Magister Curationis - MCurMental health care for adolescents is currently provided in a range of settings world-wide. These include the pediatrics units, general hospitals and specialized in-patient units for adolescents. However, care in these specialized units has hitherto not been evaluated. A phenomenological approach as a method and design was chosen to enable participants to describe and explore the lived experiences of nurses caring for adolescents in specialized psychiatric units of the selected psychiatric hospital. A purposive sampling method was used to select respondents. In-depth interviews were conducted with nurses caring for adolescents with mental health problems. Data saturation was reached with seven respondents. Interviews were recorded with a tape recorder that was only accessible to the researcher. Data analysis followed Collazi’s style that included listening to the recorded data, transcribing, coding, and intuition, reflection, reducing and interpreting the data. Ethical clearance was obtained from University of the Western Cape Higher Degrees Committee. The researcher requested permission to conduct the study at selected Psychiatric hospital from the Medical Superintendent and research ethics committee. Informed consent was also sought for those who agreed to participate in the study. Participants remained anonymous as their identity was not revealed. Only information related to the study was collected. Anonymity was assured by omitting names from transcripts as participants were given numbers only rather than using their names. The in-depth interviews were conducted in a quiet office to ensure privacy and confidentiality

Clinico comparative study of Vamana and Virechana Karma in the management of Shvitra w.s.r. to Vitiligo

Introduction: One of the baffling problems of mankind since time immemorial is the skin disease. Shvitra (Vitiligo) may become; a psychologically devastating disorder when it typically occurs in exposed areas. Aim: To evaluate and compare the efficacy of the Vamana and Virechana Karma in the management of the Shvitra (Vitiligo). Materials and Method: In this study total 92 patients of Shvitra were registered at Panchakarma dept. of I.P.G.T. & R.A. Hospital, Jamnagar. Patients were randomly divided in three groups by lottery random sampling method. In Group A - Vamana Karma and in Group B - Virechana Karma was given. After Shodhana in both Groups and in Group C Oral administration of Darvigomootra Ghanavati 6g/day with the Apamarghkshara Lepa for 8 weeks was given. Result: In VASI Score 2.16% and 4.61% relief was found in Group A and B respectively which was statistically highly significant. While in Group C 0.38% relief was found which were statistically insignificant. Conclusion: Any kind of Shodhana therapy either Vamana or Virechana play a key role in the management of Shvitra. For long far and sustainable effect of the therapy Shodhana should be performed priorly

Ayurvedic management of Intra Cranial Hypertension (IIH) - A Case Study

A 36 year old female patient came to P. D. Patel Ayurvedic Hospital, Nadiad with confirmed diagnosis of Intra Cranial Hypertension (IIH). The patient presented with chief complaint of headache (more over left side), transient vision loss and ear ache. Clinical findings showed bilateral papilloeodema (Lt>Rt). MRI showed possibilities of Idiopathic Intracranial Hypertension. The menometry showed the pressure of CSF-360 mm of water. After clinical evaluation Ayurvedic treatment was started and significant improvement was seen. The treatment during the hospitalization of one month included Sarvanga Abhyanga, Sarvanga Swedana, Niruha Basti, Marsha Nasya and oral medication. Later on after 19 days Shirodhara was started. During the stay patient was followed up for papilloeodema. As a result of the treatment the severity of the headache was decreased and papilloeodema started resolving. The menometry showed significant reduction in the pressure of CSF. The medicines were continued after discharge

Concept of Nabhi – A Review Study

The central point of body in between Amashaya (location of undigested food) and Pakvashaya (location of digested food) is termed as Nabhi. In classical texts of Ayurveda; scattered references regarding Nabhi are available like Nabhi is mentioned as a vital spot (Marma) of body. Nabhi is also included among the fifteen Koshthangas of body. In Sharirasthana of Sushruta Samhita; Acharya Sushruta mentioned that Sira and Dhamani are originated from Nabhi. Acharya Vagbhatta has quoted Nabhi as a dominant place of Pitta Dosha. Nabhi is an abode of Pranas (vital energy). Available literature and commentary on Nabhi interprets it as a Navel but practically it doesn’t make a sense to stick with this interpretation. Therefore; it is need to review classical texts of Ayurveda and contemporary literature to get clear and unambiguous meaning of the word “Nabhi” now a day. After thoroughly reading and interpreting the literature available regarding Nabhi; core of physiological process would be considered by the term Nabh

Preventive, promotive and curative aspect of Dhumapana in Urdhvajatrugata Roga

Dhumapana is very effective treatment for upper clavicular diseases (Urdhvajatrugata Roga). It is also effective in coughing (Kasa Roga) and in induction of emesis. However it is not widely practiced. The curative aspect of Dhumapana is somewhat known in clinicians but its preventive and promotive aspect is neither much known nor practiced. Different types of Dhumapana are mentioned in Ayurvedic classics, made from different Dhumavarti, using different drugs; according to the need of action. It works on Vata and Kapha Dosha. It can be used for Shamana and Shodhana Karma. It can be advised at different stages of treatment to achieve these Karma. In this article an effort has been made to elaborate the preventive, promotive and curative aspect of Dhumapana