Acute oral toxicity and phytochemical study of "Diabenorme" and "Thuquinone" used to treat diabetes

The aim of the study was conducted to search for phytochemicals and evaluate the acute oral toxicity in mice for aqueous extracts of "Diabenorme" and "Thuquinone" used in the treatment of diabetes. "Diabenorme" is a combination of two medicinal plants: Persea americana (Lauraceae) and Anacardium occidentale (Anacardiaceae) while "Thuquinone" is composed of Pycnanthus angolensis (Myristicaceae). Phytochemical analysis was done using standard methods and acute toxicity test (OCDE 423) was performed by a fixed dose procedure consist in administration of three doses of 300, 2000 and 5000 mg/kg body weight of "Diabenorme" and "Thuquinone". Phytochemical analysis showed that the different drugs contained polyphenols, flavonoids, catechin tannins, alkaloids and saponins. Concerning acute toxicity test, no sign of toxicity and mortality were observed during the experiment after limit test of 5000 mg/kg. Thus, there were no significant differences (Fischer test, P ˃ 0.05) in the body weights between the control and treated animals. These results show that the aqueous extracts of "Diabenorme" and "Thuquinone" are potentially safe for oral consumption at acute administration up to dose of 5000 mg/kg. Further investigation is needed to evaluate its sub-acute toxicity.Keywords: Diabenorme, Thuquinone, Phytochemical screening, acute toxicity

Search for supersymmetry in events with four or more leptons in √s =13 TeV pp collisions with ATLAS

Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb −1 of proton-proton collisions delivered by the Large Hadron Collider at s √ =13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of General Gauge Mediated supersymmetry, where higgsino masses are excluded up to 295 GeV. In R -parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46 TeV, 1.06 TeV, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively

Search for the direct production of charginos and neutralinos in final states with tau leptons in √s=13 TeV collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fb−1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13TeV.Nosignificant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of ˜χ+1 ˜χ−1 pair production and of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the ˜ τL state is set to be halfway between the masses of the ˜χ±1 and the ˜χ01. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of ˜χ+1 ˜χ−1 for a massless ˜χ01. Common ˜χ±1 and ˜χ02 masses up to 760 GeV are excluded in the case of production of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 assuming a massless ˜χ01. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the ˜χ±1 and the ˜χ01 are also studied by varying the ˜ τL mass between the masses of the ˜χ±1 and the ˜χ01

Studies of Zγ production in association with a high-mass dijet system in pp collisions at √s=8 TeV with the ATLAS detector

The production of a Z boson and a photon in association with a high-mass dijet system is studied using 20.2 fb −1 of proton-proton collision data at a centre-of-mass energy of s=8 TeV recorded with the ATLAS detector in 2012 at the Large Hadron Collider. Final states with a photon and a Z boson decaying into a pair of either electrons, muons, or neutrinos are analysed. Electroweak and total pp → Zγjj cross-sections are extracted in two fiducial regions with different sensitivities to electroweak production processes. Quartic couplings of vector bosons are studied in regions of phase space with an enhanced contribution from pure electroweak production, sensitive to vector-boson scattering processes VV → Zγ. No deviations from Standard Model predictions are observed and constraints are placed on anomalous couplings parameterized by higher-dimensional operators using effective field theory.[Figure not available: see fulltext.]

Search for direct top squark pair production in final states with two leptons in √s = 13 TeV pp collisions with the ATLAS detector

The results of a search for direct pair production of top squarks in events with two opposite-charge leptons (electrons or muons) are reported, using 36.1 fb−1 of integrated luminosity from proton–proton collisions at √s = 13 TeV collected by the ATLAS detector at the Large Hadron Collider. To cover a range of mass differences between the top squark t ˜ and lighter supersymmetric particles, four possible decay modes of the top squark are targeted with dedicated selections: the decay t ˜ → bχ˜ ± 1 into a b-quark and the lightest chargino with χ˜ ± 1 → Wχ˜ 0 1 , the decay t ˜ → tχ˜ 0 1 into an on-shell top quark and the lightest neutralino, the three-body decay t ˜ → bWχ˜ 0 1 and the four-body decay t ˜ → bνχ˜ 0 1 . No significant excess of events is observed above the Standard Model background for any selection, and limits on top squarks are set as a function of the t ˜ and χ˜ 0 1 masses. The results exclude at 95% confidence level t ˜ masses up to about 720 GeV, extending the exclusion region of supersymmetric parameter space covered by previous searches

Search for flavour-changing neutral current top-quark decays t → qZ in proton-proton collisions at \sqrt{s} = 13 TeV with the ATLAS detector

A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of s√=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1, are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t → qZ (q = u, c) flavour-changing neutral-current channel, and the other through the dominant Standard Model mode t → bW. Only Z boson decays into charged leptons and leptonic W boson decays are considered as signal. Consequently, the final-state topology is characterized by the presence of three isolated charged leptons (electrons or muons), at least two jets, one of the jets originating from a b-quark, and missing transverse momentum from the undetected neutrino. The data are consistent with Standard Model background contributions, and at 95% confidence level the search sets observed (expected) upper limits of 1.7 × 10−4 (2.4 × 10−4) on the t → uZ branching ratio and 2.4 × 10−4 (3.2 × 10−4) on the t → cZ branching ratio, constituting the most stringent limits to date. Open image in new windo

Search for resonances in diphoton events at √s = 13 TeV with the ATLAS detector

Searches for new resonances decaying into two photons in the ATLAS experiment at the CERN Large Hadron Collider are described. The analysis is based on proton-proton collision data corresponding to an integrated luminosity of 3.2 fb−1 at s√=13 TeV recorded in 2015. Two searches are performed, one targeted at a spin-2 particle of mass larger than 500 GeV, using Randall-Sundrum graviton states as a benchmark model, and one optimized for a spin-0 particle of mass larger than 200 GeV. Varying both the mass and the decay width, the most significant deviation from the background-only hypothesis is observed at a diphoton invariant mass around 750 GeV with local significances of 3.8 and 3.9 standard deviations in the searches optimized for a spin-2 and spin-0 particle, respectively. The global significances are estimated to be 2.1 standard deviations for both analyses. The consistency between the data collected at 13 TeV and 8 TeV is also evaluated. Limits on the production cross section times branching ratio to two photons for the two resonance types are reported

Search for Dark Matter Produced in Association with a Higgs Boson Decaying to bb[over ¯] Using 36 fb^{-1} of pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.

Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb[over ¯] pair with the ATLAS detector using 36.1  fb^{-1} of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The observed data are in agreement with the standard model predictions and limits are placed on the associated production of dark-matter particles and a Higgs boson

Precision measurement and interpretation of inclusive W+, W− and Z/γ∗ production cross sections with the ATLAS detector

High-precision measurements by the ATLAS Collaboration are presented of inclusive W+ → ` + ν, W− → ` − ν¯ and Z/γ∗ → `` (` = e, µ) Drell–Yan production cross sections at the LHC. The data were collected in proton–proton collisions at √ s = 7TeV with an integrated luminosity of 4.6 fb−1 . Differential W+ and W− cross sections are measured in a lepton pseudorapidity range |η`| < 2.5. Differential Z/γ∗ cross sections are measured as a function of the absolute dilepton rapidity, for |y``| < 3.6, for three intervals of dilepton mass, m``, extending from 46 to 150GeV. The integrated and differential electron- and muon-channel cross sections are combined and compared to theoretical predictions using recent sets of parton distribution functions. The data, together with the final inclusive e ± p scattering cross-section data from H1 and ZEUS, are interpreted in a next-to-next-to-leading-order QCD analysis, and a new set of parton distribution functions, ATLAS-epWZ16, is obtained. The ratio of strange-to-light sea-quark densities in the proton is determined more accurately than in previous determinations based on collider data only, and is established to be close to unity in the sensitivity range of the data. A new measurement of the CKM matrix element |Vcs| is also provided.Fil: Monticelli, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: The Atlas Collaboration