Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis

Air pollution has been associated with significant adverse health effects leading to increased overall morbidity and mortality of worldwide significance. Epidemiological studies have shown that the largest portion of air pollution-related mortality is due to cardiovascular diseases, predominantly those of ischemic nature. Human studies suggest an association with atherosclerosis and increasing experimental animal data support that this association is likely to be causal. While both gasses and particles have been linked to detrimental health effects, more evidence implicates the particulate matter (PM) components as major responsible for a large portion of the proatherogenic effects. Multiple experimental approaches have revealed the ability of PM components to trigger and/or enhance free radical reactions in cells and tissues, both ex vivo as well as in vivo. It appears that exposure to PM leads to the development of systemic prooxidant and proinflammatory effects that may be of great importance in the development of atherosclerotic lesions. This article reviews the epidemiological studies, experimental animal, and cellular data that support the association of air pollutants, especially the particulate components, with systemic oxidative stress, inflammation, and atherosclerosis. It also reviews the use of transcriptomic studies to elucidate molecular pathways of importance in those systemic effects

Biomechanical differences between experienced and inexperienced wheelchair users during sport

Background: During functional wheelchair movement there are several types of stroke pattern that a manual wheelchair user (MWCU) can utilize in order to propel. Objectives: To examine the biomechanical differences between disabled (WCU) and able-bodied (NWCU) children whilst taking part in functional activities at the Cheetahs Wheelchair Sports Club. Study Design: A multiple measures cohort study. Methods: Eleven participants were divided into two groups; WCU (n = 7) and NWCU (n = 4). All subjects were asked to perform three functional tasks; 30-second agility test, 1-minute distance test and a 10-metre sprint test. Upper body kinematics were recoded using a XSens MVN BIOMECH motion capture suit. Results: NWCU outperformed the WCU in all of the tasks, however, no significant differences between the group’s results were found. Nevertheless, significant differences were found in the maximum shoulder flexion angle for both right and left with NWCU utilizing more flexion and near significant differences in the NWCU overall shoulder range for right and left. Conclusions: In order to increase function in young MWCU then more specific-based sessions should be implemented targeting the exploitation of large shoulder ranges during propulsion, consequently resulting in more efficient movement. Clinical relevance Employing a propulsion technique which uses larger ranges of shoulder motion and decreased pushrim frequency results in an optimal cost-effect balance without predisposing MWCU to overuse injuries