PADS: Privacy-preserving Auction Design forAllocating Dynamically Priced Cloud Resources

With the rapid growth of Cloud Computing technologies, enterprises are increasingly deploying their services in the Cloud. Dynamically priced cloud resources such as the Amazon EC2 Spot Instance provides an efficient mechanism for cloud service providers to trade resources with potential buyers using an auction mechanism. With the dynamically priced cloud resource markets, cloud consumers can buy resources at a significantly lower cost than statically priced cloud resources such as the on-demand instances in Amazon EC2. While dynamically priced cloud resources enable to maximize datacenter resource utilization and minimize cost for the consumers, unfortunately, such auction mechanisms achieve these benefits only at a cost significant of private information leakage. In an auction-based mechanism, the private information includes information on the demands of the consumers that can lead an attacker to understand the current computing requirements of the consumers and perhaps even allow the inference of the workload patterns of the consumers. In this paper, we propose PADS, a strategy-proof differentially private auction mechanism that allows cloud providers to privately trade resources with cloud consumers in such a way that individual bidding information of the cloud consumers is not exposed by the auction mechanism. We demonstrate that PADS achieves differential privacy and approximate truthfulness guarantees while maintaining good performance in terms of revenue gains and allocation efficiency. We evaluate PADS through extensive simulation experiments that demonstrate that in comparison to traditional auction mechanisms, PADS achieves relatively high revenues for cloud providers while guaranteeing the privacy of the participating consumers

Testing surfactants as additives for clay improvement: compaction and suction effects

Environmental Geotechnics (Joint TC106-TC215 Session)This paper presents an exploratory study on surfactants as additives to improve soil properties. It is hypothesized that surfactant molecules populate the air-water interfaces reducing surface tension and suction thus allowing a control of the mechanical response of the soil. Suction measurements by means of a high suction tensiometer, compaction tests and Atterberg limits were conducted in mixtures of sand and kaolin, with and without a surfactant solution. The results revealed a prominent effect on suction, but to a lesser extent on the Atterberg limits and compaction behavior (the maximum dry density). This targeted effect of the surfactants suggests its molecules populate, not only the air-water interfaces decreasing surface tension, but may be adsorbing to the clay particles and forming micelles in the pore water as well. Therefore the interplay between the three may influence the soil behavior.published_or_final_versio

Multi-step self-guided pathways for shape-changing metamaterials

Multi-step pathways, constituted of a sequence of reconfigurations, are central to a wide variety of natural and man-made systems. Such pathways autonomously execute in self-guided processes such as protein folding and self-assembly, but require external control in macroscopic mechanical systems, provided by, e.g., actuators in robotics or manual folding in origami. Here we introduce shape-changing mechanical metamaterials, that exhibit self-guided multi-step pathways in response to global uniform compression. Their design combines strongly nonlinear mechanical elements with a multimodal architecture that allows for a sequence of topological reconfigurations, i.e., modifications of the topology caused by the formation of internal self-contacts. We realized such metamaterials by digital manufacturing, and show that the pathway and final configuration can be controlled by rational design of the nonlinear mechanical elements. We furthermore demonstrate that self-contacts suppress pathway errors. Finally, we demonstrate how hierarchical architectures allow to extend the number of distinct reconfiguration steps. Our work establishes general principles for designing mechanical pathways, opening new avenues for self-folding media, pluripotent materials, and pliable devices in, e.g., stretchable electronics and soft robotics.Comment: 16 pages, 3 main figures, 10 extended data figures. See https://youtu.be/8m1QfkMFL0I for an explanatory vide

Evidence for reversible control of magnetization in a ferromagnetic material via spin-orbit magnetic field

Conventional computer electronics creates a dichotomy between how information is processed and how it is stored. Silicon chips process information by controlling the flow of charge through a network of logic gates. This information is then stored, most commonly, by encoding it in the orientation of magnetic domains of a computer hard disk. The key obstacle to a more intimate integration of magnetic materials into devices and circuit processing information is a lack of efficient means to control their magnetization. This is usually achieved with an external magnetic field or by the injection of spin-polarized currents. The latter can be significantly enhanced in materials whose ferromagnetic properties are mediated by charge carriers. Among these materials, conductors lacking spatial inversion symmetry couple charge currents to spin by intrinsic spin-orbit (SO) interactions, inducing nonequilibrium spin polarization tunable by local electric fields. Here we show that magnetization of a ferromagnet can be reversibly manipulated by the SO-induced polarization of carrier spins generated by unpolarized currents. Specifically, we demonstrate domain rotation and hysteretic switching of magnetization between two orthogonal easy axes in a model ferromagnetic semiconductor.Comment: 10 pages including supplemental materia

Effect of particle size on the measurement of the apparent contact angle in sand of varying wettability under air-dried conditions

Session: Advances in Experimental Methods: Mechanical PropertiesChanges in the wettability of soil are known to affect several processes such as infiltration and the shear strength of soil. In this study, the wettability of a medium to fine sand was chemically modified by using different concentrations of dimethyldichlorosilane (DMDCS). The sessile drop method (SDM) was used for the assessment of wettability of hydrophobised Leighton Buzzard Sand (LBS). The results demonstrate that beyond a concentration of 2 g per kg of LBS, the finer fraction had its apparent contact angle (ACA) increased up to 115° while the maximum ACA attained by the coarser fractions was 100°. At such high concentration of DMDCS, the effect of trapped air, which is known to increase the ACA, was found to be either small or insignificant. The standard deviations of the ACAs agreed well with past studies. The most important factors contributing to the water-repellent behaviour of chemically synthesised sand were attributed to the characteristics of the particles; these include surface area and particle shape.published_or_final_versio

Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions

Mitochondrial DNA (mtDNA) mutations are a common cause of primary mitochondrial disorders, and have also been implicated in a broad collection of conditions, including aging, neurodegeneration, and cancer. Prevalent among these pathogenic variants are mtDNA deletions, which show a strong bias for the loss of sequence in the major arc between, but not including, the heavy and light strand origins of replication. Because individual mtDNA deletions can accumulate focally, occur with multiple mixed breakpoints, and in the presence of normal mtDNA sequences, methods that detect broad-spectrum mutations with enhanced sensitivity and limited costs have both research and clinical applications. In this study, we evaluated semi-quantitative and digital PCR-based methods of mtDNA deletion detection using double-stranded reference templates or biological samples. Our aim was to describe key experimental assay parameters that will enable the analysis of low levels or small differences in mtDNA deletion load during disease progression, with limited false-positive detection. We determined that the digital PCR method significantly improved mtDNA deletion detection sensitivity through absolute quantitation, improved precision and reduced assay standard error

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions

During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineated, the role of the third SMC complex, Smc5/6, remains enigmatic. Here we identify specific, essential meiotic functions for the Smc5/6 complex in homologous recombination and the regulation of cohesin. We show that Smc5/6 is enriched at centromeres and cohesin-association sites where it regulates sister-chromatid cohesion and the timely removal of cohesin from chromosomal arms, respectively. Smc5/6 also localizes to recombination hotspots, where it promotes normal formation and resolution of a subset of joint-molecule intermediates. In this regard, Smc5/6 functions independently of the major crossover pathway defined by the MutLγ complex. Furthermore, we show that Smc5/6 is required for stable chromosomal localization of the XPF-family endonuclease, Mus81-Mms4Eme1. Our data suggest that the Smc5/6 complex is required for specific recombination and chromosomal processes throughout meiosis and that in its absence, attempts at cell division with unresolved joint molecules and residual cohesin lead to severe recombination-induced meiotic catastroph

Consistency of Lambda-Lambda hypernuclear events

Highlights of Lambda-Lambda emulsion events are briefly reviewed. Given three accepted events, shell-model predictions based on p-shell Lambda hypernuclear spectroscopic studies are shown to reproduce the Lambda-Lambda (LL) binding energies of LL10Be and LL13B in terms of the LL binding energy of LL6He. Predictions for other species offer judgement on several alternative assignments of the LL13B KEK-E176 event, and on the assignments LL11Be and LL12Be suggested recently for the KEK-E373 HIDA event. The predictions of the shell model, spanning a wide range of A values, are compared with those of cluster models, where the latter are available.Comment: Based on talk given by Avraham Gal at EXA 2011, Vienna, September 2011; Proceedings version prepared for the journal Hyperfine Interactions; v2--slight changes, matches published versio

Theories for influencer identification in complex networks

In social and biological systems, the structural heterogeneity of interaction networks gives rise to the emergence of a small set of influential nodes, or influencers, in a series of dynamical processes. Although much smaller than the entire network, these influencers were observed to be able to shape the collective dynamics of large populations in different contexts. As such, the successful identification of influencers should have profound implications in various real-world spreading dynamics such as viral marketing, epidemic outbreaks and cascading failure. In this chapter, we first summarize the centrality-based approach in finding single influencers in complex networks, and then discuss the more complicated problem of locating multiple influencers from a collective point of view. Progress rooted in collective influence theory, belief-propagation and computer science will be presented. Finally, we present some applications of influencer identification in diverse real-world systems, including online social platforms, scientific publication, brain networks and socioeconomic systems.Comment: 24 pages, 6 figure

Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria

Acetate is a short-chain fatty acid secreted by Propionibacteria from the human intestine, known to induce mitochondrial apoptotic death in colorectal cancer (CRC) cells. We previously established that acetate also induces lysosome membrane permeabilization in CRC cells, associated with release of the lysosomal protease cathepsin D (CatD), which has a well-established role in the mitochondrial apoptotic cascade. Unexpectedly, we showed that CatD has an antiapoptotic role in this process, as pepstatin A (a CatD inhibitor) increased acetate-induced apoptosis. These results mimicked our previous data in the yeast system showing that acetic acid activates a mitochondria-dependent apoptosis process associated with vacuolar membrane permeabilization and release of the vacuolar protease Pep4p, ortholog of mammalian CatD. Indeed, this protease was required for cell survival in a manner dependent on its catalytic activity and for efficient mitochondrial degradation independently of autophagy. In this study, we therefore assessed the role of CatD in acetate-induced mitochondrial alterations. We found that, similar to acetic acid in yeast, acetate-induced apoptosis is not associated with autophagy induction in CRC cells. Moreover, inhibition of CatD with small interfering RNA or pepstatin A enhanced apoptosis associated with higher mitochondrial dysfunction and increased mitochondrial mass. This effect seems to be specific, as inhibition of CatB and CatL with E-64d had no effect, nor were these proteases significantly released to the cytosol during acetate-induced apoptosis. Using yeast cells, we further show that the role of Pep4p in mitochondrial degradation depends on its protease activity and is complemented by CatD, indicating that this mechanism is conserved. In summary, the clues provided by the yeast model unveiled a novel CatD function in the degradation of damaged mitochondria when autophagy is impaired, which protects CRC cells from acetate-induced apoptosis. CatD inhibitors could therefore enhance acetate-mediated cancer cell death, presenting a novel strategy for prevention or therapy of CRC.FEDER through POFC – COMPETE and by Fundação para a Ciência e Tecnologia through projects PEst-OE/BIA/UI4050/2014 and FCT ANR/BEX-BCM/0175/201