Perinatal Gene Transfer to the Liver

The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within the first weeks or months of life is inevitable. Some diseases can be managed using conventional medicines whereas others are, as yet, untreatable. In this review we consider the application of early intervention gene therapy in neonatal and fetal preclinical studies. We appraise the tools of this technology, including lentivirus, adenovirus and adeno-associated virus (AAV)-based vectors. We highlight the application of these for a range of diseases including hemophilia, urea cycle disorders such as ornithine transcarbamylase deficiency, organic acidemias, lysosomal storage diseases including mucopolysaccharidoses, glycogen storage diseases and bile metabolism. We conclude by assessing the advantages and disadvantages associated with fetal and neonatal liver gene transfer

D=3, N=8 conformal supergravity and the Dragon window

We give a superspace description of D=3, N=8 supergravity. The formulation is off-shell in the sense that the equations of motion are not implied by the superspace constraints (but an action principle is not given). The multiplet structure is unconventional, which we connect to the existence of a "Dragon window", that is modules occurring in the supercurvature but not in the supertorsion. According to Dragon's theorem this cannot happen above three dimensions. We clarify the relevance of this window for going on the conformal shell, and discuss some aspects of coupling to conformal matter.Comment: plain tex, 24 pp v2: minor change

A Self-Reference False Memory Effect in the DRM Paradigm: Evidence from Eastern and Western Samples

It is well established that processing information in relation to oneself (i.e., selfreferencing) leads to better memory for that information than processing that same information in relation to others (i.e., other-referencing). However, it is unknown whether self-referencing also leads to more false memories than other-referencing. In the current two experiments with European and East Asian samples, we presented participants the Deese-Roediger/McDermott (DRM) lists together with their own name or other people’s name (i.e., “Trump” in Experiment 1 and “Li Ming” in Experiment 2). We found consistent results across the two experiments; that is, in the self-reference condition, participants had higher true and false memory rates compared to those in the other-reference condition. Moreover, we found that selfreferencing did not exhibit superior mnemonic advantage in terms of net accuracy compared to other-referencing and neutral conditions. These findings are discussed in terms of theoretical frameworks such as spreading activation theories and the fuzzytrace theory. We propose that our results reflect the adaptive nature of memory in the sense that cognitive processes that increase mnemonic efficiency may also increase susceptibility to associative false memories

N=2 supergravity and supercurrents

We address the problem of classifying all N=2 supercurrent multiplets in four space-time dimensions. For this purpose we consider the minimal formulation of N=2 Poincare supergravity with a tensor compensator, and derive its linearized action in terms of three N=2 off-shell multiplets: an unconstrained scalar superfield, a vector multiplet, and a tensor multiplet. Such an action was ruled out to exist in the past. Using the action constructed, one can derive other models for linearized N=2 supergravity by applying N=2 superfield duality transformations. The action depends parametrically on a constant non-vanishing real isotriplet g^{ij}=g^{ji} which originates as an expectation value of the tensor compensator. Upon reduction to N=1 superfields, we show that the model describes two dually equivalent formulations for the massless multiplet (1,3/2)+(3/2,2) depending on a choice of g^{ij}. In the case g^{11}=g^{22}=0, the action describes (i) new minimal N=1 supergravity; and (ii) the Fradkin-Vasiliev-de Wit-van Holten gravitino multiplet. In the case g^{12}=0, on the other hand, the action describes (i) old minimal N=1 supergravity; and (ii) the Ogievetsky-Sokatchev gravitino multiplet.Comment: 40 pages; v2: added references, some comments, new appendi

Variant supercurrent multiplets

In N = 1 rigid supersymmetric theories, there exist three standard realizations of the supercurrent multiplet corresponding to the (i) old minimal, (ii) new minimal and (iii) non-minimal off-shell formulations for N = 1 supergravity. Recently, Komargodski and Seiberg in arXiv:1002.2228 put forward a new supercurrent and proved its consistency, although in the past it was believed not to exist. In this paper, three new variant supercurrent multiplets are proposed. Implications for supergravity-matter systems are discussed.Comment: 11 pages; V2: minor changes in sect. 3; V3: published version; V4: typos in eq. (2.3) corrected; V5: comments and references adde

N=2 Conformal Superspace in Four Dimensions

We develop the geometry of four dimensional N=2 superspace where the entire conformal algebra of SU(2,2|2) is realized linearly in the structure group rather than just the SL(2,C) x U(2)_R subgroup of Lorentz and R-symmetries, extending to N=2 our prior result for N=1 superspace. This formulation explicitly lifts to superspace the existing methods of the N=2 superconformal tensor calculus; at the same time the geometry, when degauged to SL(2,C) x U(2)_R, reproduces the existing formulation of N=2 conformal supergravity constructed by Howe.Comment: 43 pages; v2 references added, acknowledgments update

Towards Field Theory Amplitudes From the Cohomology of Pure Spinor Superspace

A simple BRST-closed expression for the color-ordered super-Yang-Mills 5-point amplitude at tree-level is proposed in pure spinor superspace and shown to be BRST-equivalent to the field theory limit of the open superstring 5-pt amplitude. It is manifestly cyclic invariant and each one of its five terms can be associated to the five Feynman diagrams which use only cubic vertices. Its form also suggests an empirical method to find superspace expressions in the cohomology of the pure spinor BRST operator for higher-point amplitudes based on their kinematic pole structure. Using this method, Ansaetze for the 6- and 7-point 10D super-Yang-Mills amplitudes which map to their 14 and 42 color-ordered diagrams are conjectured and their 6- and 7-gluon expansions are explicitly computed.Comment: 14 pages, harvmac, v4: trivial edits in the text to comply with JHEP refere

Ectoplasm with an Edge

The construction of supersymmetric invariant actions on a spacetime manifold with a boundary is carried out using the "ectoplasm" formalism for the construction of closed forms in superspace. Non-trivial actions are obtained from the pull-backs to the bosonic bodies of closed but non-exact forms in superspace; finding supersymmetric invariants thus becomes a cohomology problem. For a spacetime with a boundary, the appropriate mathematical language changes to relative cohomology, which we use to give a general formulation of off-shell supersymmetric invariants in the presence of boundaries. We also relate this construction to the superembedding formalism for the construction of brane actions, and we give examples with bulk spacetimes of dimension 3, 4 and 5. The closed superform in the 5D example needs to be constructed as a Chern-Simons type of invariant, obtained from a closed 6-form displaying Weil triviality.Comment: 25 page

Pure spinor superfields -- an overview

Maximally supersymmetric theories do not allow off-shell superspace formulations with traditional superfields containing a finite set of auxiliary fields. It has become clear that off-shell supersymmetric action formulations of such models can be achieved by the introduction of pure spinors. In this talk, an overview of this formalism is given, with emphasis on D=10 super-Yang-Mills theory and D=11 supergravity. This a somewhat expanded version of a talk presented at the workshop "Breaking of supersymmetry and ultraviolet divergences in extended supergravity" (BUDS), Laboratori Nazionali di Frascati, March 25-28, 2013.Comment: 34 pp., 2 figs., contributions to the proceedings of the workshop "Breaking of supersymmetry and ultraviolet divergences in extended supergravity" (BUDS), Laboratori Nazionali di Frascati, March 25-28, 201

Sigma models with off-shell N=(4,4) supersymmetry and noncommuting complex structures

We describe the conditions for extra supersymmetry in N=(2,2) supersymmetric nonlinear sigma models written in terms of semichiral superfields. We find that some of these models have additional off-shell supersymmetry. The (4,4) supersymmetry introduces geometrical structures on the target-space which are conveniently described in terms of Yano f-structures and Magri-Morosi concomitants. On-shell, we relate the new structures to the known bi-hypercomplex structures.Comment: 20 pages; v2: significant corrections, clarifications, and reorganization; v3: discussion of supersymmetry vs twisted supersymmetry added, relevant signs corrected