A comprehensive overview of radioguided surgery using gamma detection probe technology

The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology

Organisational Structure’s Influence on IT Alignment: The Case of a Public Organisation

IT alignment, even though extensively researched in the last decades, remains to be challenging. Previous studies are criticised for two reasons. First, the majority of the studies focus on the conceptual debate, while practical issues that have implications on IT alignment are overlooked. One of these issues is the influence of organisational structure on IT alignment. Second, studies in few organisational settings, namely private and commercial organisations, have resulted in findings that are not applicable for organisations in other sectors–public organisations. To address the gap in the literature, this study aims to explore the influence of formal and informal organisational structures on IT alignment in a public organisation. As public organisations are joining the trend of digital transformation, identifying appropriate organisational structure that foster IT alignment is an important and timely issue. The result of the case study, conducted in one Swedish municipality, revealed the influence of centralised organisational structure as well as three types of informal organisational structure—interpersonal relationships, professional networks, and crossdepartmental relationships—on IT alignment. The findings could be used by leaders in public organisations to design an effective organisational structure that can improve IT alignment and its maturity.</p

Do Feeding and Eating Disorders Fit the General Definition of Mental Disorder?

AbstractThis paper aims at considering the conceptual status of feeding and eating disorders (FEDs). Now that the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) has changed the classification and some relevant criteria of FEDs, it is particularly relevant to evaluate their psychiatric framework and their status as mental disorders. I focus my efforts on addressing only one specific question: Do FEDs fit the DSM-5 general definition of mental disorder? In DSM-5 a mental disorder is defined as a syndrome that reflects a dysfunction and is usually associated with significant distress or disability. More importantly, there is an explicit statement saying that all mental disorders listed in the manual must meet the requirements highlighted by the general definition. Thus, I evaluate whether or not FEDs are really meant to reflect a dysfunction and are usually associated with significant distress or disability