Front Matter

Front Matte

Front Matter

Front Matte

Front Matter

Front Matte

Front Matter

Front Matte

Distinct factors determine the kinetics of disease relapse in adults transplanted for acute myeloid leukaemia

Background. Disease recurrence remains the major cause of death in adults with acute myeloid leukaemia (AML) treated using either intensive chemotherapy (IC) or allogenic stem cell transplantation (allo-SCT). Aims. The timely delivery of maintenance drug or cellular therapies represent emerging strategies with the potential to reduce relapse after both treatment modalities, but whilst the determinants of overall relapse risk have been extensively characterized the factors determining the timing of disease recurrence have not been characterized. Materials and Methods. We have therefore examined, using a series of sequential landmark analyses, relapse kinetics in a cohort of 2028 patients who received an allo-SCT for AML in CR1 and separately 570 patients treated with IC alone. Results. In the first 3 months after allo-SCT, the factors associated with an increased risk of relapse included the presence of the FLT3-ITD (P <0.001), patient age (P = 0.012), time interval from CR1 to transplant (P <0.001) and donor type (P = 0.03). Relapse from 3 to 6 months was associated with a higher white cell count at diagnosis (P = 0.001), adverse-risk cytogenetics (P <0.001), presence of FLT3-ITD mutation (P <0.001) and time interval to achieve first complete remission (P = 0.013). Later relapse was associated with adverse cytogenetics, mutated NPM1, absence of chronic graft-versus-host disease (GVHD) and the use of in vivo T-cell depletion. In patients treated with IC alone, the factors associated with relapse in the first 3 months were adverse-risk cytogenetics (P <0.001) and FLT3-ITD status (P = 0.001). The factors predicting later relapse were the time interval from diagnosis to CR1 (P = 0.22) and time interval from CR1 to IC (P = 0.012). Discussion and Conclusion. Taken together, these data provide novel insights into the biology of disease recurrence after both allo-SCT and IC and have the potential to inform the design of novel maintenance strategies in both clinical settings.Peer reviewe

Dinamika Peran Indonesia Di Arf : Upaya Menyelaraskan Kepentingan Nasional Dengan Tekanan Stuktur Internasional

This study examines the driven factors of Indonesian involvement and developments in the ARF (ASEAN Regional Forum) by applying neo-classical realism perspective. The driven factors are both the external factors such as International structure, and internal ones such as political economic situation, regime interests, and leadership role that are giving impact to Indonesia's foreign policy implementations. The involvement of Indonesia in ARF is primarily influenced by a changing structure of International politics and security in Asia Pacific. In order to ensure the stability of the country that has been integrated into ASEAN, Indonesia is actively involved in the ARF. While, Indonesia's active participation in the multilateral forum is generally to show its role as a leading country in Southeast Asia, and try to balancing powers structure in the region through ASEAN. Thus, to understanding the driven factors of Indonesia's involvement in ARF are correspondence with neoclassical realism theory, which states that country's behavior in the International system needs to be interpreted by variables such as International structure and domestic factors

Nonrelativistic Chern-Simons Vortices on the Torus

A classification of all periodic self-dual static vortex solutions of the Jackiw-Pi model is given. Physically acceptable solutions of the Liouville equation are related to a class of functions which we term Omega-quasi-elliptic. This class includes, in particular, the elliptic functions and also contains a function previously investigated by Olesen. Some examples of solutions are studied numerically and we point out a peculiar phenomenon of lost vortex charge in the limit where the period lengths tend to infinity, that is, in the planar limit.Comment: 25 pages, 2+3 figures; improved exposition, corrected typos, added one referenc

Relapse of lupus nephritis – risk factors and impact of mycophenolate treatment

P16 Poster Session: SLE Epidemiology and risk factors: abstract no. 427published_or_final_versio