Distribution of forensic marker allelic frequencies in pernambuco, Northestern Brazil

7siPernambuco is one of the 27 federal units of Brazil, ranking seventh in the number of inhabitants. We examined the allele frequencies of 13 short tandem repeat loci (CFS1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, vWA, and TPOX), the minimum recommended by the Federal Bureau of Investigation and commonly used in forensic genetics laboratories in Brazil, in a sample of 609 unrelated individuals from all geographic regions of Pernambuco. The allele frequencies ranged from 5 to 47.2%. No significant differences for any loci analyzed were observed compared with other publications in other various regions of Brazil. Most of the markers observed were in Hardy-Weinberg equilibrium. The occurrence of the allele 47.2 (locus FGA) and alleles 35.1 and 39 (locus D21S11), also described in a single study of the Brazilian population, was observed. The other forensic parameters analyzed (matching probability, power of discrimination, polymorphic information content, paternity exclusion, complement factor I, observed heterozygosity, expected heterozygosity) indicated that the studied markers are very informative for human forensic identification purposes in the Pernambuco population.openopenSantos, S.M.; Souza, C.A.; Rabelo, K.C.N.; Souza, P.; Moura, R.R.; Oliveira, T.C.; Crovella, S.Santos, S. M.; Souza, C. A.; Rabelo, K. C. N.; Souza, P.; Moura, R. R.; Oliveira, T. C.; Crovella, Sergi

The Borborema Pegmatite Province, NE-Brazil revisited

Considering the internal structure, mineralogical distribution and geochemical data on K-feldspar, white micas, Nb-Taoxides, tourmalines, garnet and spinel, it becomes clear that the pegmatites classified as "heterogeneous" (Johnston 1945) include examples of several types and subtypes of LCT family, Rare Element Class pegmatites if the modern pegmatite classification models of Černý & Ercit 2005 are applied: at least examples of the beryl-columbite, beryl-columbite-phosphate and complex-spodumene,complex-lepidolite (±gemmologic elbaite)and albite (± cassiterite) pegmatite types and subtypes were ntatively identified. The impossibility to determine a granitelinked zoned regional distribution of these types may be the result of the fact that there is no single central source pluton but several smaller granitic intrusions in the province and the zoning around them may overlap each other

Classes of exact wavefunctions for general time-dependent Dirac Hamiltonians in 1+1 dimensions

In this work we construct two classes of exact solutions for the most general time-dependent Dirac Hamiltonian in 1+1 dimensions. Some problems regarding to some formal solutions in the literature are discussed. Finally the existence of a generalized Lewis-Riesenfeld invariant connected with such solutions is discussed

Scalar field in cosmology: Potential for isotropization and inflation

The important role of scalar field in cosmology was noticed by a number of authors. Due to the fact that the scalar field possesses zero spin, it was basically considered in isotropic cosmological models. If considered in an anisotropic model, the linear scalar field does not lead to isotropization of expansion process. One needs to introduce scalar field with nonlinear potential for the isotropization process to take place. In this paper the general form of scalar field potentials leading to the asymptotic isotropization in case of Bianchi type-I cosmological model, and inflationary regime in case of isotropic space-time is obtained. In doing so we solved both direct and inverse problem, where by direct problem we mean to find metric functions and scalar field for the given potential, whereas, the inverse problem means to find the potential and scalar field for the given metric function. The scalar field potentials leading to the inflation and isotropization were found both for harmonic and proper synchronic time.Comment: 10 page

Viability of Noether symmetry of F(R) theory of gravity

Canonization of F(R) theory of gravity to explore Noether symmetry is performed treating R - 6(\frac{\ddot a}{a} + \frac{\dot a^2}{a^2} + \frac{k}{a^2}) = 0 as a constraint of the theory in Robertson-Walker space-time, which implies that R is taken as an auxiliary variable. Although it yields correct field equations, Noether symmetry does not allow linear term in the action, and as such does not produce a viable cosmological model. Here, we show that this technique of exploring Noether symmetry does not allow even a non-linear form of F(R), if the configuration space is enlarged by including a scalar field in addition, or taking anisotropic models into account. Surprisingly enough, it does not reproduce the symmetry that already exists in the literature (A. K. Sanyal, B. Modak, C. Rubano and E. Piedipalumbo, Gen.Relativ.Grav.37, 407 (2005), arXiv:astro-ph/0310610) for scalar tensor theory of gravity in the presence of R^2 term. Thus, R can not be treated as an auxiliary variable and hence Noether symmetry of arbitrary form of F(R) theory of gravity remains obscure. However, there exists in general, a conserved current for F(R) theory of gravity in the presence of a non-minimally coupled scalar-tensor theory (A. K. Sanyal, Phys.Lett.B624, 81 (2005), arXiv:hep-th/0504021 and Mod.Phys.Lett.A25, 2667 (2010), arXiv:0910.2385 [astro-ph.CO]). Here, we briefly expatiate the non-Noether conserved current and cite an example to reveal its importance in finding cosmological solution for such an action, taking F(R) \propto R^{3/2}.Comment: 16 pages, 1 figure. appears in Int J Theoretical Phys (2012

Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome

SPOAN syndrome is a neurodegenerative disorder mainly characterized by spastic paraplegia, optic atrophy and neuropathy (SPOAN). Affected patients are wheelchair bound after 15 years old, with progressive joint contractures and spine deformities. SPOAN patients also have sub normal vision secondary to apparently non-progressive congenital optic atrophy. A potential causative gene was mapped at 11q13 ten years ago. Here we performed next-generation sequencing in SPOAN-derived samples. While whole-exome sequencing failed to identify the causative mutation, whole-genome sequencing allowed to detect a homozygous 216-bp deletion (chr11.hg19:g.66,024,557_66,024,773del) located at the non-coding upstream region of the KLC2 gene. Expression assays performed with patient’s fibroblasts and motor neurons derived from SPOAN patients showed KLC2 overexpression. Luciferase assay in constructs with 216-bp deletion confirmed the overexpression of gene reporter, varying from 48 to 74%, as compared with wild-type. Knockdown and overexpression of klc2 in Danio rerio revealed mild to severe curly-tail phenotype, which is suggestive of a neuromuscular disorder. Overexpression of a gene caused by a small deletion in the non-coding region is a novel mechanism, which to the best of our knowledge, was never reported before in a recessive condition. Although the molecular mechanism of KLC2 up-regulation still remains to be uncovered, such example adds to the importance of non-coding regions in human pathologyFil: Melo, Uira S.. Universidade de Sao Paulo; BrasilFil: Macedo Souza, Lucia I.. Universidade de Sao Paulo; BrasilFil: Figueiredo, Thalita. Federal University of Paraiba; Brasil. Paraiba State University; BrasilFil: Muotri, Alysson R. University of California at San Diego; Estados UnidosFil: Gleeson, Joseph G.. The Rockefeller University; Estados UnidosFil: Coux, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Armas, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Calcaterra, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Kitajima, João P.. Mendelics Genomic Analysis; BrasilFil: Amorim, Simone. Universidade de Sao Paulo; BrasilFil: Olávio, Thiago R.. Universidade de Sao Paulo; BrasilFil: Griesi Oliveira, Karina. Universidade de Sao Paulo; BrasilFil: Coatti, Giuliana C.. Universidade de Sao Paulo; BrasilFil: Rocha, Clarissa R.R. Universidade de Sao Paulo; BrasilFil: Martins Pinheiro, Marinalva. Universidade de Sao Paulo; BrasilFil: Menck, Carlos F.M.. Universidade de Sao Paulo; BrasilFil: Zaki, Maha S.. National Research Center. EL Cairo; EgiptoFil: Kok, Fernando. Universidade de Sao Paulo; BrasilFil: Zatz, Mayana. Universidade de Sao Paulo; BrasilFil: Santos, Silvana. Federal University of Paraiba; Brasil. Paraiba State University; Brasi

Quasiparticle Interactions in Fractional Quantum Hall Systems: Justification of Different Hierarchy Schemes

The pseudopotentials describing the interactions of quasiparticles in fractional quantum Hall (FQH) states are studied. Rules for the identification of incompressible quantum fluid ground states are found, based upon the form of the pseudopotentials. States belonging to the Jain sequence nu=n/(1+2pn), where n and p are integers, appear to be the only incompressible states in the thermodynamic limit, although other FQH hierarchy states occur for finite size systems. This explains the success of the composite Fermion picture.Comment: RevTeX, 10 pages, 7 EPS figures, submitted fo Phys.Rev.

Measurement of the Bottom contribution to non-photonic electron production in p+pp+p collisions at s\sqrt{s} =200 GeV

The contribution of $B$ meson decays to non-photonic electrons, which are mainly produced by the semi-leptonic decays of heavy flavor mesons, in $p+p$ collisions at $\sqrt{s} =$ 200 GeV has been measured using azimuthal correlations between non-photonic electrons and hadrons. The extracted $B$ decay contribution is approximately 50% at a transverse momentum of $p_{T} \geq 5$ GeV/$c$. These measurements constrain the nuclear modification factor for electrons from $B$ and $D$ meson decays. The result indicates that $B$ meson production in heavy ion collisions is also suppressed at high $p_{T}$.Comment: 6 pages, 4 figures, accepted by PR

Screening, production and biochemical characterization of a new fibrinolytic enzyme produced by Streptomyces sp. (Streptomycetaceae) isolated from Amazonian lichens

Thrombosis is a pathophysiological disorder caused by accumulation of fibrin in the blood. Fibrinolytic proteases with potent thrombolytic activity have been produced by diverse microbial sources. Considering the microbial biodiversity of the Amazon region, this study aimed at the screening, production and biochemical characterization of a fibrinolytic enzyme produced by Streptomyces sp. isolated from Amazonian lichens. The strain Streptomyces DPUA1576 showed the highest fibrinolytic activity, which was 283 mm2. Three variables at two levels were used to assess their effects on the fibrinolytic production. The parameters studied were agitation (0.28 - 1.12 g), temperature (28 - 36 ºC) and pH (6.0 - 8.0); all of them had significant effects on the fibrinolytic production. The maximum fibrinolytic activity (304 mm2) was observed at 1.12 g, 28 ºC, and pH of 8.0. The crude extract of the fermentation broth was used to assess the biochemical properties of the enzyme. Protease and fibrinolytic activities were stable during 6 h, at a pH ranging from 6.8 to 8.4 and 5.8 to 9.2, respectively. Optimum temperature for protease activity ranged between 35 and 55 °C, while the highest fibrinolytic activity was observed at 45 ºC. Proteolytic activity was inhibited by Cu2+ and Co2+ ions, phenylmethylsulfonyl fluoride (PMSF) and pepstatin A, which suggests that the enzyme is a serine protease. Enzymatic extract cleaved fibrinogen at the subunits A-chain, A-chain, and -chain. The results indicated that Streptomyces sp. DPUA 1576 produces enzymes with fibrinolytic and fibrinogenolytic activity, enzymes with an important application in the pharmaceutical industry.The authors grateful acknowledge the financial support of Fundação de Amparo a Pesquisa do Estado de Pernambuco (FACEPE, Pernambuco, Brazil, N. 0158-2.12/11), CNPq/ RENORBIO (National Counsel of Technological and Scientific Development, N.55146/2010-3) and National Council for the Improvement of Higher Education (CAPES, Brazil) for the scholarship. The author thanks editor and reviewers for their review and comments.info:eu-repo/semantics/publishedVersio