Harnessing the potential of ligninolytic enzymes for lignocellulosic biomass pretreatment

Abundant lignocellulosic biomass from various industries provides a great potential feedstock for the production of value-added products such as biofuel, animal feed, and paper pulping. However, low yield of sugar obtained from lignocellulosic hydrolysate is usually due to the presence of lignin that acts as a protective barrier for cellulose and thus restricts the accessibility of the enzyme to work on the cellulosic component. This review focuses on the significance of biological pretreatment specifically using ligninolytic enzymes as an alternative method apart from the conventional physical and chemical pretreatment. Different modes of biological pretreatment are discussed in this paper which is based on (i) fungal pretreatment where fungi mycelia colonise and directly attack the substrate by releasing ligninolytic enzymes and (ii) enzymatic pretreatment using ligninolytic enzymes to counter the drawbacks of fungal pretreatment. This review also discusses the important factors of biological pretreatment using ligninolytic enzymes such as nature of the lignocellulosic biomass, pH, temperature, presence of mediator, oxygen, and surfactant during the biodelignification process

At what institutions did Nobel laureates do their prize-winning work? An analysis of biographical information on Nobel laureates from 1994 to 2014

In this study we examined the institutions (and countries) the Nobel laureates of the three disciplines chemistry, physics and physiology/medicine were affiliated with (from 1994 to 2014) when they did the decisive research work. To be able to frame the results at that time point, we also looked at when the Nobel laureates obtained their Ph.D./M.D. and when they were awarded the Nobel Prize. We examined all 155 Nobel laureates of the last 21 years in physics, chemistry, and physiology/medicine. Results showed that the USA dominated as a country. Statistical analysis also revealed that only three institutions can boast a larger number of Nobelists at all three time points examined: UC Berkeley, Columbia University and the Massachusetts Institute of Technology (MIT). Researcher mobility analysis made clear that most of the Nobel laureates were mobile; either after having obtained their Ph.D./M.D. or after writing significant papers that were decisive for the Nobel Prize. Therefore, we distinguished different ways of mobility between countries and between institutions. In most cases, the researchers changed institutes/universities within one and the same country (in first position: the USA, followed, by far, by the United Kingdom, Japan and Germany)