Evaluation of a service intervention to improve awareness and uptake of bowel cancer screening in ethnically-diverse areas

The Policy Research Unit in Cancer Awareness, Screening and Early Diagnosis receives funding for a research programme from the UK Department of Health Policy Research Programme (grant no. 106/0001). It is a collaboration between researchers from seven institutions (the Queen Mary University of London, the UCL, the King’s College London, the London School of Hygiene and Tropical Medicine, the Hull York Medical School, the Durham University and the Peninsula Medical School)

Priming Analogical Reasoning with False Memories

Like true memories, false memories are capable of priming answers to insight-based problems. Recent research has attempted to extend this paradigm to more advanced problem-solving tasks, including those involving verbal analogical reasoning. However, these experiments are constrained inasmuch as problem solutions could be generated via spreading activation mechanisms (much like false memories themselves) rather than using complex reasoning processes. In three experiments we examined false memory priming of complex analogical reasoning tasks in the absence of simple semantic associations. In Experiment 1, we demonstrated the robustness of false memory priming in analogical reasoning when backward associative strength among the problem terms was eliminated. In Experiments 2a and 2b, we extended these findings by demonstrating priming on newly created homonym analogies that can only be solved by inhibiting semantic associations within the analogy. Overall, the findings of the present experiments provide evidence that the efficacy of false memory priming extends to complex analogical reasoning problems

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

The Ursinus Weekly, December 3, 1962

Fourteen Ursinus seniors named to Who\u27s Who in American Colleges • 25th annual Messiah performance scheduled for Thursday evening • Sophomore dance set for Saturday • A report from the president of the men\u27s student government • Computers to be topic of Math Club meeting • Lord & lady, permanent officers named at Friday\u27s senior ball • Russia subject of recent Y lecturer • Relevance of the parish church topic of theologian tomorrow • Curriculum changes discussed • Pre-medicals hear kidney lecture • Editorial: Toward a better Messiah • Alumni snatches • Letters to the editor • Constant activity a way of life with Dr. Maurice Armstrong • Eastern Baptist downs UC cagers 72-59 in season\u27s opener Saturday • Women cagers set schedule • Intramural story • Gymnasium hours set for winter season • Women\u27s swim team faces full schedulehttps://digitalcommons.ursinus.edu/weekly/1282/thumbnail.jp

Social media use, attitudes, behaviours and perceptions of online professionalism amongst dental students

Use of social media has increased amongst health professionals. This has benefits for patient care but also introduces risks for confidentiality and professional fitness to practise. This study aimed to examine dental student attitudes towards professional behaviour on social media. The secondary aim was to establish the extent and nature of social media use and exposure to potentially unprofessional behaviours. A cross-sectional study was carried out in one dental school. Data were collected using questionnaires to examine social media use, perceptions and attitudes towards social media and professional behaviours online. Students who responded (n=155) all used social media at least once per week; most used more than one platform. Students were aware of the relationship between social media use and professional practice. Posting drunken photographs and interacting with staff and patients online were widely considered as unprofessional. Security settings affected behaviour and most had seen inappropriate behaviours online. Students use social media extensively. Students are aware of the risks but there is a greater sense of safety in closed groups and many students are exposed to potentially inappropriate content online. This suggests that there are opportunities to reduce these risks through training to help students manage these risks

Thresholds of large N factorization in CFT4: exploring bulk spacetime in AdS(5)

52 pages, 6 figures52 pages, 6 figure

Relative judgement is relatively difficult: evidence against the role of relative judgement in absolute identification

A variety of processes have been put forward to explain absolute identification performance. One difference between current models of absolute identification is the extent to which the task involves accessing stored representations in long-term memory (e.g. exemplars in memory, Kent & Lamberts, Journal of Experimental Psychology: Learning Memory and Cognition, 31, 289–305, 2005) or relative judgement (comparison of the current stimulus to the stimulus on the previous trial, Stewart, Brown & Chater, Psychological Review, 112, 881–911, 2005). In two experiments we explored this by tapping into these processes. In Experiment 1 participants completed an absolute identification task using eight line lengths whereby a single stimulus was presented on each trial for identification. They also completed a matching task aimed at mirroring exemplar comparison in which eight line lengths were presented in a circular array and the task was to report which of these matched a target presented centrally. Experiment 2 was a relative judgement task and was similar to Experiment 1 except that the task was to report the difference (jump-size) between the current stimulus and that on the previous trial. The absolute identification and matching data showed clear similarities (faster and more accurate responding for stimuli near the edges of the range and similar stimulus-response confusions). In contrast, relative judgment performance was poor suggesting relative judgement is not straightforward. Moreover, performance as a function of jump-size differed considerably between the relative judgement and absolute identification tasks. Similarly, in the relative judgement task, predicting correct stimulus identification based on successful relative judgement yielded the reverse pattern of performance observed in the absolute identification task. Overall, the data suggest that relative judgement does not underlie absolute identification and that the task is more likely reliant on an exemplar comparison process

The Ursinus Weekly, January 7, 1963

Burst water pipes in 724 lead to semi-evacuation • Speaker from GE will discuss US in space race • PSEA features talks by grad, student teachers • Ed Myers selected representative to National Committee for Youth • College laments death of director Douthett • Psychiatry topic of pre-med meeting • Dolman attends forum on education problems • New heating & power plant now in service • Cub & Key, men\u27s honorary, now accepting applications • Curtain Club version of Antigone scheduled for second semester • Dr. Vorrath concludes discussion of changes in Spanish courses • Schweiker talks on GOP future • Leber open house a Christmas highlight • Chessmen compete in national event • Lynne Maloney, Miss Penna. \u2761, wed last month • Editorial: Unjust, unfair, unwise • Letters to the editor • Snyder to train Civil Defense people • Wrestlers open season Saturday by smashing scared Fords 31-3 • Ursinus gridmen named to MAC all-star teams • Netmen downed by Haverford 72-56 • Intramural story • Ursinus women\u27s club honors Marion Spanglerhttps://digitalcommons.ursinus.edu/weekly/1284/thumbnail.jp

The Ursinus Weekly, October 30, 1961

Loyalty kick-off dinner features famous co-eds • Ursinus College treats Homecoming visitors to decorations, dinners, sports, and a dance: Haverford foe for Homecoming tilt; Campus readied • Six fraternity queens grace Homecoming scene • Work abroad plan offered by ASIS • Pfahler film festival shows Henry V, LaStrada • Placenta subject for Dr. Rathmell in pre-med talk • Senator Smith sees moral force as Khrushchev\u27s chief enemy • A-Phi-O welcomes thirteen pledges • Princeton\u27s Homrighausen visits here tomorrow • Dr. Parsons publishes Norris journal excerpt • Editorial: Censorship here • U.S. government offers junior Summer work • Social Security interview Friday in U.C. Library • Ursinus in the past • U.C. man is drag champ • The Late George Apley Curtain Club Fall choice • MSGA imposes fines for firebox tampering • Ursinus booters beat Muhlenberg, 2-1; Lose to Swarthmore Wenesday, 4-1 • Field hockey girls beat Stroudsburg • Leber-South unbeaten, unscored upon; Leads touch football teams • Wagner wrecks Bear hopes for a \u2761 winning campaign • Sophomore Scholl mainstay at end; Solid defensively, slick offensively • Dean\u27s listhttps://digitalcommons.ursinus.edu/weekly/1302/thumbnail.jp

Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer

Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating and reducing breast cancer progression in ER-positive disease. However, resistance to these therapies presents a major clinical problem. Recent genetic studies have shown that mutations in the ER gene are found in >20% of tumours that progress on endocrine therapies. Remarkably, the great majority of these mutations localize to just a few amino acids within or near the critical helix 12 region of the ER hormone binding domain, where they are likely to be single allele mutations. Understanding how these mutations impact on ER function is a prerequisite for identifying methods to treat breast cancer patients featuring such mutations. Towards this end, we used CRISPR-Cas9 genome editing to make a single allele knock-in of the most commonly mutated amino acid residue, tyrosine 537, in the estrogen-responsive MCF7 breast cancer cell line. Genomic analyses using RNA-seq and ER ChIP-seq demonstrated that the Y537S mutation promotes constitutive ER activity globally, resulting in estrogen-independent growth. MCF7-Y537S cells were resistant to the anti-estrogen tamoxifen and fulvestrant. Further, we show that the basal transcription factor TFIIH is constitutively recruited by ER-Y537S, resulting in ligand-independent phosphorylation of Serine 118 (Ser118) by the TFIIH kinase, cyclin-dependent kinase (CDK)7. The CDK7 inhibitor, THZ1 prevented Ser118 phosphorylation and inhibited growth of MCF7-Y537S cells. These studies confirm the functional importance of ER mutations in endocrine resistance, demonstrate the utility of knock-in mutational models for investigating alternative therapeutic approaches and highlight CDK7 inhibition as a potential therapy for endocrine-resistant breast cancer mediated by ER mutations