An 18S ribosomal DNA barcode for the study of Isomermis lairdi, a parasite of the blackfly Simulium damnosum s.l.

The mermithid parasite, Isomermis lairdi Mondet, Poinar & Bernadou (Nematoda: Mermithidae), is known to have a major impact on populations of Simulium damnosum s.l. Theobald (Diptera: Simuliidae) and on their efficiency as vectors of Onchocerca volvulus (Leuckart) (Nematoda: Filarioidea). However, the value of I. lairdi and other mermithid parasites as potential means of integrated vector control has not been fully realized. This is partly because traditional taxonomic approaches have been insufficient for describing and analysing important aspects of their biology and host range. In total, rDNA barcode sequences have been obtained from over 70 I. lairdi mermithids found parasitizing S. damnosum s.l. larvae in three different rivers. No two sequences were found to vary by more than 0.5%, and cytospecies identification of mermithid hosts revealed that I. lairdi with identical rDNA barcodes can parasitize multiple cytoforms of the S. damnosum complex, including S. squamosum (Enderlein). Phylogenetic analysis using a partial sequence from the 18S ribosomal DNA barcode, grouped I. lairdi in a monophyletic group with Gastromermis viridis Welch (Nematoda: Mermithidae) and Isomermis wisconsinensis Welch (Nematoda: Mermithidae)

Impact of proctoring on success rates for percutaneous revascularisation of coronary chronic total occlusions.

OBJECTIVE: To assess the impact of proctoring for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in six UK centres. METHODS: We retrospectively analysed 587 CTO procedures from six UK centres and compared success rates of operators who had received proctorship with success rates of the same operators before proctorship (pre-proctored) and operators in the same institutions who had not been proctored (non-proctored). There were 232 patients in the pre-proctored/non-proctored group and 355 patients in the post-proctored group. Complexity was assessed by calculating the Japanese CTO (JCTO) score for each case. RESULTS: CTO PCI success was greater in the post-proctored compared with the pre-proctored/non-proctored group (77.5% vs 62.1%, p<0.0001). In more complex cases where JCTO≥2, the difference in success was greater (70.7% vs 49.5%, p=0.0003). After proctoring, there was an increase in CTO PCI activity in centres from 2.5% to 3.5%, p<0.0001 (as a proportion of total PCI), and the proportion of very difficult cases with JCTO score ≥3 increased from 15.3% (35/229) to 29.7% (105/354), p<0.0001. CONCLUSIONS: Proctoring resulted in an increase in procedural success for CTO PCI, an increase in complex CTO PCI and an increase in total CTO PCI activity. Proctoring may be a valuable way to improve access to CTO PCI and the likelihood of procedural success

Resolving structure of the disc around HD100546 at 7 mm with ATCA

There is much evidence that planet formation is occurring in the disc around the Herbig Be star HD100546. To learn more about the processes occurring in this disc, we conducted high-resolution imaging at 43/45 GHz with the Australia Telescope Compact Array. Multiple array configurations were used, providing a best spatial resolution of ∼0.15 arcsec, or 15 au at HD100546's distance of ∼100 pc. Significant structure is revealed, but its precise form is dependent on the u − v plane sampling used for the image reconstruction. At a resolution of ≤30 au, we detected an inner gap in the disc with a radius of ∼25 au and a position angle approximately along the known disc major axis. With different weighting, and an achieved resolution of ∼15 au, emission appears at the centre and the disc takes on the shape of an incomplete ring, much like a horseshoe, again with a gap radius of ∼25 au. The position angle of the disc major axis and its inclination from face-on are determined to be 140° ± 5° and 40° ± 5°, respectively. The ∼25 au gap radius is confirmed by a null in the real part of the binned visibilities at 320 ± 10 kλ, whilst the non-axisymmetric nature is also confirmed through significant structure in the imaginary component. The emission mechanism at the central peak is most likely to be free–free emission from a stellar or disc wind. Overall our data support the picture of at least one, but probably several, giant planets orbiting HD100546 within 25 au

Unified force law for granular impact cratering

Experiments on the low-speed impact of solid objects into granular media have been used both to mimic geophysical events and to probe the unusual nature of the granular state of matter. Observations have been interpreted in terms of conflicting stopping forces: product of powers of projectile depth and speed; linear in speed; constant, proportional to the initial impact speed; and proportional to depth. This is reminiscent of high-speed ballistics impact in the 19th and 20th centuries, when a plethora of empirical rules were proposed. To make progress, we developed a means to measure projectile dynamics with 100 nm and 20 us precision. For a 1-inch diameter steel sphere dropped from a wide range of heights into non-cohesive glass beads, we reproduce prior observations either as reasonable approximations or as limiting behaviours. Furthermore, we demonstrate that the interaction between projectile and medium can be decomposed into the sum of velocity-dependent inertial drag plus depth-dependent friction. Thus we achieve a unified description of low-speed impact phenomena and show that the complex response of granular materials to impact, while fundamentally different from that of liquids and solids, can be simply understood

Successful new product development by optimizing development process effectiveness in highly regulated sectors: the case of the Spanish medical devices sector

Rapid development and commercialization of new products is of vital importance for small and medium sized enterprises (SME) in regulated sectors. Due to strict regulations, competitive advantage can hardly be achieved through the effectiveness of product concepts only. If an SME in a highly regulated sector wants to excell in new product development (NPD) performance, the company should focus on the flexibility, speed, and productivity of its NPD function: i.e. the development process effectiveness. Our main research goals are first to explore if SMEs should focus on their their development process effectiveness rather than on their product concept effectiveness to achieve high NPD performance; and second, to explore whether a shared pattern in the organization of the NPD function can be recognized to affect NPD performance positively. The medical devices sector in Spain is used as an example of a\ud highly regulated sector. A structured survey among 11 SMEs, of which 2 were studied also as in in-depth case studies, led to the following results. First of all, indeed the companies in the dataset which focused on the effectiveness of their development process, stood out in NPD performance. Further, the higher performing companies did have a number of commonalities in the organisation of their NPD function: 1) The majority of the higher performing firms had an NPD strategy characterized by a predominantly incremental project portfolio.\ud 2) a) Successful firms with an incremental project portfolio combined this with a functional team structure b) Successful firms with a radical project portfolio combined this with a heavyweight or autonomous team structure.\ud 3) A negative reciprocal relationship exists between formalization of the NPD processes and the climate of the NPD function, in that a formalized NPD process and an innovative climate do not seem to reinforce each other. Innovative climate combined with an informal NPD process does however contribute positively to NPD performance. This effect was stronger in combination with a radical project portfolio. The highest NPD performance was measured for companies focusing mainly on incremental innovation. It is argued that in highly regulated sectors, companies with an incremental product portfolio would benefit from employing a functional structure. Those companies who choose for a more radical project portfolio in highly regulated sectors should be aware\ud that they are likely to excell only in the longer term by focusing on strategic flexibility. In their NPD organization, they might be well advised to combine informal innovation processes with an innovative climate

Protection of Humanity’s Cultural and Historic Heritage in Space

While the international community has acted forcefully since World War II to protect sites and objects of cultural or historic significance on Earth, little attention has been paid to the same kinds of sites and objects in space. There are important ethical and scholarly reasons for wanting to preserve sites and in situ objects in off-Earth contexts from destruction or commercial exploitation. Innovative space research equipment, such as spacecraft, satellites, and space stations, and the locations of historic missions, such as Tranquility Base, therefore deserve formal international recognition and protection. Appropriate models for developing a comprehensive protective scheme can be found in existing international protocols, especially the 1959 Antarctic Treaty (and later additions), the 1970 UNESCO Convention on Cultural Property, the 1972 UNESCO World Heritage Convention, and the 2001 UNESCO Convention on the Underwater Cultural Heritage. In addition, space agencies and professional organizations can mandate adequate and ethical planning for the post-operational phases of space missions to include arrangements for heritage protection

Severan Marble Plan of Rome data files

In its original state, the Severan Marble Plan of Rome, placed on the wall of the Temple of Peace between 203 and 211 CE, showed viewers the locations of buildings throughout Rome, and even the groundplan of each of those buildings. It is today an extraordinary piece of evidence for understanding the city in that time period, despite its ruinous state. It survives in over 1,100 fragments, representing only about 10% of its original surface area. To date, scholars have successfully placed only about 100 of those fragments with respect to the buildings they depict. Using GIS and CAD software, I have digitized those fragments whose locations are known and placed them in their appropriate positions over a topographical map and satellite image of the modern city. The file is geo-referenced using the UTM coordinate system, so that the photos and drawings correspond to real-world coordinates. I correlated the placement of individual buildings with excavated remains. Scholars have long known that there are surveying errors on the Plan, though there is disagreement about the number and extent of those errors. One advantage of digitization is its flexibility; one can not only adjust the placement of any individual fragment for greater accuracy, but can also change the spacing and orientation of different buildings on a single fragment. This project gives the most precise understanding yet of the surveying and cartographic methods employed on the Plan, and it allows for the ready integration of future information from newly excavated remains. The included documents consist of .TIF raster files showing the fragments from La pianta marmorea di Roma antica, by Carettoni, Colini, Cozza, and Gatti (1960); a rectified 1980’s-era Soviet satellite image of the city; a scan of a 1:25,000 military map made by the Italian Istituto Geografico Militare published in 1949; the .DWG file with all of the above placed in it, along with vector layers showing the edges of map fragments and the carvings on the maps. There is also a PDF export of the .DWG file with layers, and a PDF document explaining the project.https://digitalcommons.chapman.edu/art_data/1001/thumbnail.jp

A Silver Service and a Gold Coin

The published history of a set of silver and gold objects acquired by the J. Paul Getty Museum in 1975 contains an unusual reference to a gold coin, supposedly found with the set but not purchased by the museum. The coin, which is both rare and well dated, ostensibly offers a date and location for the ancient deposition of the silver service. Almost five years of research into the stories of the Getty objects and the coin has revealed important information about these particular items, but it also offers a cautionary example for scholars who might hope to reconstruct the find-spot of antiquities that are likely to have been looted

Reclaiming my Indigenous Identity and the Emerging Warrior: An Autoethnography

This autoethnography describes the Natalie St-Denis’ four-year journey in Indigenous social work, characterized as: awakening, exploring, indigenizing, reclaiming, belonging, and emerging Warrior. Awakening began with seeing herself as an ‘Indigenous woman’ and is retold through remembrances, reflections and conversations.  In the second phase, guided by Elders, she embraces ceremony to explore her emerging identity. Adopting Indigenous ways of knowing, being and doing serves to indigenize -- the third phase of the journey. Reclaiming, the fourth phase, is the actor’s reconciliation of both indigenous and Western worldviews, and in belonging, she describes the reconstruction of an Indigenous community.  The final phase, emerging Warrior, concerns the integration of her personal and professional social work practitioner identity. St-Denis’ journey is revealed within the complicity of the social work profession in historical and ongoing colonization of Indigenous peoples in Canada.  The Warrior is offered as a pathway to decolonize social work praxis

Traditional Healing Practices in an Urban Indigenous Setting: An Autoethnography

A growing number of Indigenous and non-Indigenous social workers are actively working towards the decolonization of their practice. However, incorporating traditional healing practices within an urban Indigenous setting requires commitment and dedication to understanding these practices.  Relationships with Elders and access to traditional healing practices have been advanced as critical in this process.Frameworks on how to do this work have been proposed, yet few have included stories of how these approaches are interwoven into daily practice in an urban Indigenous context. The goal of this autoethnography is to share experiences and reflections of frontline work and to further the dialogue to improve services for urban Indigenous peoples accessing social services. It is through the process of decolonization that social workers, not only fulfill their ethical professional obligations, but also contribute to reconciliation and the healing journey of Indigenous peoples