Perineal massage in labour and prevention of perineal trauma: randomised controlled trial

Objective: To determine the effects of perineal massage in the second stage of labour on perineal outcomes. Design: Randomised controlled trial. Participants: At 36 weeks' gestation, women expecting normal birth of a singleton were asked to join the study. Women became eligible to be randomised in labour if they progressed to full dilatation of the cervix or 8 cm or more if nulliparous or 5 cm or more if multiparous. 1340 were randomised into the trial. Intervention: Massage and stretching of the perineum during the second stage of labour with a water soluble lubricant. Main outcome measures: Primary outcomes: rates of intact perineum, episiotomies, and first, second, third, and fourth degree tears. Secondary outcomes: pain at three and 10 days postpartum and pain, dyspareunia, resumption of sexual intercourse, and urinary and faecal incontinence and urgency three months postpartum. Results: Rates of intact perineums, first and second degree tears, and episiotomies were similar in the massage and the control groups. There were fewer third degree tears in the massage group (12 (1.7%) v 23 (3.6%); absolute risk 2.11, relative risk 0.45; 95% confidence interval 0.23 to 0.93, P<0.04), though the trial was underpowered to measure this rarer outcome. Groups did not differ in any of the secondary outcomes at the three assessment points. Conclusions: The practice of perineal massage in labour does not increase the likelihood of an intact perineum or reduce the risk of pain, dyspareunia, or urinary and faecal problems.Georgina Stamp, Gillian Kruzins, Caroline Crowthe

Entanglement Sharing and Decoherence in the Spin-Bath

The monogamous nature of entanglement has been illustrated by the derivation of entanglement sharing inequalities - bounds on the amount of entanglement that can be shared amongst the various parts of a multipartite system. Motivated by recent studies of decoherence, we demonstrate an interesting manifestation of this phenomena that arises in system-environment models where there exists interactions between the modes or subsystems of the environment. We investigate this phenomena in the spin-bath environment, constructing an entanglement sharing inequality bounding the entanglement between a central spin and the environment in terms of the pairwise entanglement between individual bath spins. The relation of this result to decoherence will be illustrated using simplified system-bath models of decoherence.Comment: 5 pages, 1 figure v2: 6 pages 2 figures, additional example and reference

Method of Collective Degrees of Freedom in Spin Coherent State Path Integral

We present a detailed field theoretic description of those collective degrees of freedom (CDF) which are relevant to study macroscopic quantum dynamics of a quasi-one-dimensional ferromagnetic domain wall. We apply spin coherent state path integral (SCSPI) in the proper discrete time formalism (a) to extract the relevant CDF's, namely, the center position and the chirality of the domain wall, which originate from the translation and the rotation invariances of the system in question, and (b) to derive effective action for the CDF's by elimination of environmental zero-modes with the help of the {\it Faddeev-Popov technique}. The resulting effective action turns out to be such that both the center position and the chirality can be formally described by boson coherent state path integral. However, this is only formal; there is a subtle departure from the latter.Comment: 10 pages, 1 figur

Sharp transition for single polarons in the one-dimensional Su-Schrieffer-Heeger model

We study a single polaron in the Su-Schrieffer-Heeger (SSH) model using four different techniques (three numerical and one analytical). Polarons show a smooth crossover from weak to strong coupling, as a function of the electron-phonon coupling strength $\lambda$, in all models where this coupling depends only on phonon momentum $q$. In the SSH model the coupling also depends on the electron momentum $k$; we find it has a sharp transition, at a critical coupling strength $\lambda_c$, between states with zero and nonzero momentum of the ground state. All other properties of the polaron are also singular at $\lambda = \lambda_c$, except the average number of phonons in the polaronic cloud. This result is representative of all polarons with coupling depending on $k$ and $q$, and will have important experimental consequences (eg., in ARPES and conductivity experiments)

Quantum Relaxation of Magnetisation in Magnetic Particles

At temperatures below the magnetic anisotropy energy, monodomain magnetic systems (small particles, nanomagnetic devices, etc.) must relax quantum mechanically. This quantum relaxation must be mediated by the coupling to both nuclear spins and phonons (and electrons if either particle or substrate is conducting. We analyze the effect of each of these couplings, and then combine them. Conducting systems can be modelled by a "giant Kondo" Hamiltonian, with nuclear spins added in as well. At low temperatures, even microscopic particles on a conducting substrate (containing only $10-50$ spins) will have their magnetisation frozen over millenia by a combination of electronic dissipation and the "degeneracy blocking" caused by nuclear spins. Raising the temperature leads to a sudden unblocking of the spin dynamics at a well defined temperature. Insulating systems are quite different. The relaxation is strongly enhanced by the coupling to nuclear spins. At short times the magnetisation of an ensemble of particles relaxes logarithmically in time, after an initial very fast decay; this relaxation proceeds entirely via the nuclear spins. At longer times phonons take over, but the decay rate is still governed by the temperature-dependent nuclear bias field acting on the particles - decay may be exponential or power-law depending on the temperature. The most surprising feature of the results is the pivotal role played by the nuclear spins. The results are relevant to any experiments on magnetic particles in which interparticle dipolar interactions are unimportant. They are also relevant to future magnetic device technology.Comment: 30 pages, RevTex, e:mail , Submitted to J.Low Temp.Phys. on 1 Nov. 199

What are the interactions in quantum glasses?

The form of the low-temperature interactions between defects in neutral glasses is reconsidered. We analyse the case where the defects can be modelled either as simple 2-level tunneling systems, or tunneling rotational impurities. The coupling to strain fields is determined up to 2nd order in the displacement field. It is shown that the linear coupling generates not only the usual $1/r^3$ Ising-like interaction between the rotational tunneling defect modes, which cause them to freeze around a temperature $T_G$, but also a random field term. At lower temperatures the inversion symmetric tunneling modes are still active - however the coupling of these to the frozen rotational modes, now via the 2nd-order coupling to phonons, generates another random field term acting on the inversion symmetric modes (as well as shorter-range $1/r^5$ interactions between them). Detailed expressions for all these couplings are given.Comment: 12 pages, 2 figures. Minor modifications, published versio

Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.

Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tThis is the final version of the article. Available from Public Library of Science via the DOI in this record.Many common diseases of the gas exchange surface of the lung have no specific treatment but cause serious morbidity and mortality. Idiopathic Pulmonary Fibrosis (IPF) is characterized by alveolar epithelial cell injury, interstitial inflammation, fibroblast proliferation and collagen accumulation within the lung parenchyma. Keratinocyte Growth Factor (KGF, also known as FGF-7) is a critical mediator of pulmonary epithelial repair through stimulation of epithelial cell proliferation. During repair, the lung not only uses resident cells after injury but also recruits circulating bone marrow-derived cells (BMDC). Several groups have used Mesenchymal Stromal Cells (MSCs) as therapeutic vectors, but little is known about the potential of Hematopoietic Stem cells (HSCs). Using an inducible lentiviral vector (Tet-On) expressing KGF, we were able to efficiently transduce both MSCs and HSCs, and demonstrated that KGF expression is induced in a regulated manner both in vitro and in vivo. We used the in vivo bleomycin-induced lung fibrosis model to assess the potential therapeutic effect of MSCs and HSCs. While both populations reduced the collagen accumulation associated with bleomycin-induced lung fibrosis, only transplantation of transduced HSCs greatly attenuated the histological damage. Using double immunohistochemistry, we show that the reduced lung damage likely occurs through endogenous type II pneumocyte proliferation induced by KGF. Taken together, our data indicates that bone marrow transplantation of lentivirus-transduced HSCs can attenuate lung damage, and shows for the first time the potential of using an inducible Tet-On system for cell based gene therapy in the lung.The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. DB is a Cancer Research UK principle Investigator. SJ was an MRC Clinician Scientist. This work was in part funded by a Johnson and Johnson “Focussed Giving Grant” to SJ and partly undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme (SJ) and by internal Cancer Research UK funding (DB)

Charge-Spin Separation in 2D Fermi Systems: Singular Interactions as Modified Commutators, and Solution of 2D Hubbard Model in Bosonized Approximation

The general 2-dimensional fermion system with repulsive interactions (typified by the Hubbard Model) is bosonized, taking into account the finite on-shell forward scattering phase shift derived in earlier papers. By taking this phase shift into account in the bosonic commutation relations a consistent picture emerges showing the charge-spin separation and anomalous exponents of the Luttinger liquid.Comment: Latex file 14 pages. email: [email protected]

On the Stability and Single-Particle Properties of Bosonized Fermi Liquids

We study the stability and single-particle properties of Fermi liquids in spatial dimensions greater than one via bosonization. For smooth non-singular Fermi liquid interactions we obtain Shankar's renormalization- group flows and reproduce well known results for quasi-particle lifetimes. We demonstrate by explicit calculation that spin-charge separation does not occur when the Fermi liquid interactions are regular. We also explore the relationship between quantized bosonic excitations and zero sound modes and present a concise derivation of both the spin and the charge collective mode equations. Finally we discuss some aspects of singular Fermi liquid interactions.Comment: 13 pages plus three postscript figures appended; RevTex 3.0; BUP-JBM-