Numerical studies of tunneling in a nonharmonic time-dependent potential

Azbel' has recently carried out a WKB-analysis of the effects of a nonharmonic time-dependent perturbation embedded in an opaque potential barrier. He suggests the existence of three different transmission regimes: direct tunneling, activation assisted tunneling, and elevator resonant activation. We address the same problem with a numerical technique, and find qualitative agreement with Azbel's picture.Comment: LaTeX document, 15 pages. 4 figures (Fig. 2 comes in 7 pages) in postscript appended to the LaTeX documen

Cultural Crisis, Erosion of Biological Diversity and the People’s Response

Binigyang pansin sa papel na ito ang mahigpit na kaugnavan ng krisis kultural-- partikular ang komodipikasyon ng lupa, pagkawala ng tradisyunal na sistema ng kaalaman at ang walang habas na paggamit ng teknolohiya-- sa pagkaubos ng biodiversity o saribuhay. Ipinahayag din na ang pagkasira ng saribuhay ang nagdudulot ng ibayo pang kaligaligan sa lipunan tulad ng nangyayari sa mga Katutubo. Ipinakita rin na bagamat nangyayari ang magkakambal na krisis, may mga sumusulpot namang tugon mula sa mga tao upang protektahan ang kapaligiran at lipunan

Refinement of Techniques Metallographic Analysis of Highly Dispersed Structures

Flaws are regularly made while developing standards and technical specifications. They can come out as minor misprints, as an insufficient description of a technique. In spite the fact that the flaws are well known, it does not come to the stage of introducing changes to standards. In this paper shows that in the normative documents is necessary to clarify the requirements for metallurgical microscopes, which are used for analysis of finely-dispersed

Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer.

Background:Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors influencing this risk are unknown. We aimed to determine whether high intratumor heterogeneity of ER predicts an increased long-term risk (25 years) of fatal breast cancer. Methods:The STO-3 trial enrolled 1780 postmenopausal lymph node-negative breast cancer patients randomly assigned to receive adjuvant tamoxifen vs not. The fraction of cancer cells for each ER intensity level was scored by breast cancer pathologists, and intratumor heterogeneity of ER was calculated using Rao's quadratic entropy and categorized into high and low heterogeneity using a predefined cutoff at the second tertile (67%). Long-term breast cancer-specific survival analyses by intra-tumor heterogeneity of ER were performed using Kaplan-Meier and multivariable Cox proportional hazard modeling adjusting for patient and tumor characteristics. Results:A statistically significant difference in long-term survival by high vs low intratumor heterogeneity of ER was seen for all ER-positive patients (P < .001) and for patients with luminal A subtype tumors (P = .01). In multivariable analyses, patients with high intratumor heterogeneity of ER had a twofold increased long-term risk as compared with patients with low intratumor heterogeneity (ER-positive: hazard ratio [HR] = 1.98, 95% confidence interval [CI] = 1.31 to 3.00; luminal A subtype tumors: HR = 2.43, 95% CI = 1.18 to 4.99). Conclusions:Patients with high intratumor heterogeneity of ER had an increased long-term risk of fatal breast cancer. Interestingly, a similar long-term risk increase was seen in patients with luminal A subtype tumors. Our findings suggest that intratumor heterogeneity of ER is an independent long-term prognosticator with potential to change clinical management, especially for patients with luminal A tumors

Introduction

People-in-Environment, Environment-in-Peopl