Factors affecting the long-term outcomes of idiopathic membranous nephropathy

Abstract Background We attempted to describe the clinical features and determine the factors associated with renal survival in idiopathic membranous nephropathy (iMN) patients with nephrotic syndrome (NS) and to determine the factors associated with spontaneous complete remission (sCR) and progression to NS in iMN patients with subnephrotic proteinuria. Methods This retrospective study involved 166 iMN patients with NS and 65 patients with subnephrotic proteinuria. The primary end point was a doubling of serum creatinine or initiation of dialysis. In patients with subnephrotic proteinuria, we determined the factors associated with sCR and factors associated with progression to NS. Results Remission of NS was achieved in 125 out of 166 patients (75.3%). Of those who reached remission, 26 patients (20.8%) experienced relapse that was followed by second remission. The relapse or persistence of proteinuria was associated with the primary end points (hazard ratio [HR] = 12.40, P = 0.037, HR = 173, P < 0.001, respectively). In patients with subnephrotic proteinuria, sCR occurred in 35.4% of the patients. The patients with sCR had lower proteinuria and serum creatinine levels and higher serum albumin concentrations at baseline. The serum albumin level at diagnosis was a prognostic factor for progression to NS (Odds ratio [OR] = 0.015, P < 0.001). Conclusions The occurrence of relapse or persistence of proteinuria had negative effects on renal survival in iMN patients with NS, and low serum albumin levels at baseline were associated with non-achievement of sCR and progression to NS

Post-Stenotic Recirculating Flow May Cause Hemodynamic Perforator Infarction

Background and Purpose The primary mechanism underlying paramedian pontine infarction (PPI) is atheroma obliterating the perforators. Here, we encountered a patient with PPI in the post-stenotic area of basilar artery (BA) without a plaque, shown, by high-resolution magnetic resonance imaging (HR-MRI). We performed an experiment using a 3D-printed BA model and a particle image velocimetry (PIV) to explore the hemodynamic property of the post-stenotic area and the mechanism of PPI. Methods 3D-model of a BA stenosis was reconstructed with silicone compound using a 3D printer based on the source image of HR-MRI. Working fluid seeded with fluorescence particles was used and the velocity of those particles was measured horizontally and vertically. Furthermore, microtubules were inserted into the posterior aspect of the model to measure the flow rates of perforators (pre- and post-stenotic areas). The flow rates were compared between the microtubules. Results A recirculating flow was observed from the post-stenotic area in both directions forming a spiral shape. The velocity of the flow in these regions of recirculation was about one-tenth that of the flow in other regions. The location of recirculating flow well corresponded with the area with low-signal intensity at the time-of-flight magnetic resonance angiography and the location of PPI. Finally, the flow rate through the microtubule inserted into the post-stenotic area was significantly decreased comparing to others (P<0.001). Conclusions Perforator infarction may be caused by a hemodynamic mechanism altered by stenosis that induces a recirculation flow. 3D-printed modeling and PIV are helpful understanding the hemodynamics of intracranial stenosis.114Ysciescopu

Compact groups with a dense free abelian subgroup

The compact groups having a dense infinite cyclic subgroup (known as monothetic compact groups) have been studied by many authors for their relevance and nice applications. In this paper we describe in full details the compact groups $K$ with a dense free abelian subgroup $F$ and we describe the minimum rank $r_t(K)$ of such a subgroup $F$ of $K$. Surprisingly, it is either finite or coincides with the density character $d(K)$ of $K$.

Hydrodynamic condition and suspended sediment diffusion in the Yellow Sea and East China Sea

Based on monthly averaged current, temperature, and salinity, we analyzed the changes of suspended sediment concentration (SSC) and the relationship with the warm current, coastal current, and cold water mass (CWM) in the East China Seas (ECSs). The result shows that the coastal current and surface diluted water are the route for transporting suspended sediment. The Kuroshio and its derived warm current branches play the important role of the continental shelf circulation system and control the diffusion of suspended sediment. High SSC has been mainly concentrated in coastal current and CWM. Two sedimentary dynamic patterns have been identified. The winter‐half‐year pattern lasts almost 7 months. The coastal currents off the Shandong Peninsula, northern Jiangsu, Zhejiang‐Fujian coast are the main routes for diffusion and deposition of the suspended sediment from the Yellow River and Changjiang River. The summer‐half‐year pattern is characterized by the well‐developed CWM. All CWMs have a unique function to trap suspended sediment under the thermocline due to weakening tidal current and residual current there. These CWMs in the Yellow Sea (YS) and north ECS are connected together. The layer above the thermocline is characterized by diluted water with low salinity, high temperature. Suspended sediment can be transported into the Okinawa Trough and the South Korea coast during this period. A strong eddy always occur nearby the Kuroshio bend at northeast Taiwan, which has promoted the exchange between the ECS shelf and Okinawa Trough, and the development of the shelf edge current and Taiwan warm current (TWC)

Fluid Annotation: A Human-Machine Collaboration Interface for Full Image Annotation

We introduce Fluid Annotation, an intuitive human-machine collaboration interface for annotating the class label and outline of every object and background region in an image. Fluid annotation is based on three principles: (I) Strong Machine-Learning aid. We start from the output of a strong neural network model, which the annotator can edit by correcting the labels of existing regions, adding new regions to cover missing objects, and removing incorrect regions. The edit operations are also assisted by the model. (II) Full image annotation in a single pass. As opposed to performing a series of small annotation tasks in isolation, we propose a unified interface for full image annotation in a single pass. (III) Empower the annotator. We empower the annotator to choose what to annotate and in which order. This enables concentrating on what the machine does not already know, i.e. putting human effort only on the errors it made. This helps using the annotation budget effectively. Through extensive experiments on the COCO+Stuff dataset, we demonstrate that Fluid Annotation leads to accurate annotations very efficiently, taking three times less annotation time than the popular LabelMe interface.Comment: ACM MultiMedia 2018. Live demo is available at fluidann.appspot.co

Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ.

Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma in situ (DCIS) are poorly understood. Here, we investigated myoepithelial cells in normal breast tissues of BRCA1 and BRCA2 germline mutation carriers and in non-carrier controls, and in sporadic DCIS. We found that in the normal breast of non-carriers, myoepithelial cells frequently co-express the p63 and TCF7 transcription factors and that p63 and TCF7 show overlapping chromatin peaks associated with differentiated myoepithelium-specific genes. In contrast, in normal breast tissues of BRCA1 mutation carriers the frequency of p63+TCF7+ myoepithelial cells is significantly decreased and p63 and TCF7 chromatin peaks do not overlap. These myoepithelial perturbations in normal breast tissues of BRCA1 germline mutation carriers may play a role in their higher risk of breast cancer. The fraction of p63+TCF7+ myoepithelial cells is also significantly decreased in DCIS, which may be associated with invasive progression

Oxidation behavior of graphene-coated copper at intrinsic graphene defects of different origins

The development of ultrathin barrier films is vital to the advanced semiconductor industry. Graphene appears to hold promise as a protective coating; however, the polycrystalline and defective nature of engineered graphene hinders its practical applications. Here, we investigate the oxidation behavior of graphene-coated Cu foils at intrinsic graphene defects of different origins. Macro-scale information regarding the spatial distribution and oxidation resistance of various graphene defects is readily obtained using optical and electron microscopies after the hot-plate annealing. The controlled oxidation experiments reveal that the degree of structural deficiency is strongly dependent on the origins of the structural defects, the crystallographic orientations of the underlying Cu grains, the growth conditions of graphene, and the kinetics of the graphene growth. The obtained experimental and theoretical results show that oxygen radicals, decomposed from water molecules in ambient air, are effectively inverted at Stone-Wales defects into the graphene/Cu interface with the assistance of facilitators