47 research outputs found

    Are ACPA-positive and ACPA-negative RA the same disease?

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    Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies.Pathophysiology and treatment of rheumatic disease
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