Uncovering the mechanism leading to the synthesis of symmetric and asymmetric Tröger's bases

Tröger´s bases have been attracting great interest due to their potential applications in nanoelectronics, supramolecular chemistry, molecular recognition, biological activity and auxiliaries for asymmetric synthesis. However, a detailed step by step proposal for the mechanism leading to the production of these compounds is still uncovered. A set of five model syntheses of symmetric and asymmetric Tröger´s base derivatives starting from substituted anilines and formaldehyde was done and envisaged as representative for understanding the underlying mechanism. All reasonable pathways were thoroughly scanned by means of DFT calculations. The highest energy TS was associated with the entrance of the first formaldehyde which produces the first out of three key carbocations. The last step, the closure of the methylene-bridged diazocyne heterocycle was also found of kinetic relevance and as a source of stable intermediates or byproducts. The whole mechanistic picture would provide keys for the rational planning of the synthesis of these compounds.Fil: Lanza, Priscila Ailín. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mar del Plata. Instituto de Investigaciones En Biodiversidad y Biotecnologia. Grupo de Investigacion En Quimica Analitica y Modelado Molecular.; ArgentinaFil: Dusso, Diego. Departamento de Química; ArgentinaFil: Ramirez, Cristina Lujan. Universidad Nacional de Mar del Plata; ArgentinaFil: Parise, Alejandro Ruben. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mar del Plata. Instituto de Investigaciones En Biodiversidad y Biotecnologia. Grupo de Investigacion En Quimica Analitica y Modelado Molecular.; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Chesta, Carlos Alberto. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Moyano, Elizabeth Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Vera, Domingo Mariano Adolfo. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mar del Plata. Instituto de Investigaciones En Biodiversidad y Biotecnologia. Grupo de Investigacion En Quimica Analitica y Modelado Molecular.; Argentin

OTA Students’ Perceptions of an Inter & Intraprofessional Level I Experience in Morocco

Cultural immersion experiences provide students with authentic, real-life opportunities to engage with clients serving as a powerful tool to enhance students’ global perspectives of occupation (Humbert, Burket, Deveney, & Kennedy, 2012). Interprofessional & intraprofessional education provides students with an increased understanding of the unique knowledge, skills, scope, function, & roles within their own & among other disciplines (IEC, 2011; Jung, Salvatori, & Martin, 2008)