Physics Reach of DUNE with a Light Sterile Neutrino

We investigate the implications of one light eV scale sterile neutrino on the physics potential of the proposed long-baseline experiment DUNE. If the future short-baseline experiments confirm the existence of sterile neutrinos, then it can affect the mass hierarchy (MH) and CP-violation (CPV) searches at DUNE. The MH sensitivity still remains above 5$\sigma$ if the three new mixing angles ($\theta_{14}, \theta_{24}, \theta_{34}$) are all close to $\theta_{13}$. In contrast, it can decrease to 4$\sigma$ if the least constrained mixing angle $\theta_{34}$ is close to its upper limit $\sim 30^0$. We also assess the sensitivity to the CPV induced both by the standard CP-phase $\delta_{13} \equiv \delta$, and the new CP-phases $\delta_{14}$ and $\delta_{34}$. In the 3+1 scheme, the discovery potential of CPV induced by $\delta_{13}$ gets deteriorated compared to the 3$\nu$ case. In particular, the maximal sensitivity (reached around $\delta_{13}$ $\sim$ $\pm$ $90^0$) decreases from $5\sigma$ to $4\sigma$ if all the three new mixing angles are close to $\theta_{13}$. It can further diminish to almost $3\sigma$ if $\theta_{34}$ is large ($\sim 30^0$). The sensitivity to the CPV due to $\delta_{14}$ can reach 3$\sigma$ for an appreciable fraction of its true values. Interestingly, $\theta_{34}$ and its associated phase $\delta_{34}$ can influence both the $\nu_e$ appearance and $\nu_\mu$ disappearance channels via matter effects, which in DUNE are pronounced. Hence, DUNE can also probe CPV induced by $\delta_{34}$ provided $\theta_{34}$ is large. We also reconstruct the two phases $\delta_{13}$ and $\delta_{14}$. The typical 1$\sigma$ uncertainty on $\delta_{13}$ ($\delta_{14}$) is $\sim20^0$ ($30^0$) if $\theta_{34} =0$. The reconstruction of $\delta_{14}$ (but not that of $\delta_{13}$) degrades if $\theta_{34}$ is large.Comment: 26 pages, 8 figures, 2 tables. Minor revisions. Accepted in JHE

Octant of θ23\theta_{23} in danger with a light sterile neutrino

Present global fits of world neutrino data hint towards non-maximal $\theta_{23}$ with two nearly degenerate solutions, one in the lower octant ($\theta_{23} <\pi/4$), and the other in the higher octant ($\theta_{23} >\pi/4$). This octant ambiguity of $\theta_{23}$ is one of the fundamental issues in the neutrino sector, and its resolution is a crucial goal of next-generation long-baseline (LBL) experiments. In this letter, we address for the first time, the impact of a light eV-scale sterile neutrino towards such a measurement, taking the Deep Underground Neutrino Experiment (DUNE) as a case study. In the so-called 3+1 scheme involving three active and one sterile neutrino, the $\nu_\mu \to \nu_e$ transition probability probed in the LBL experiments acquires a new interference term via active-sterile oscillations. We find that this novel interference term can mimic a swap of the $\theta_{23}$ octant, even if one uses the information from both neutrino and antineutrino channels. As a consequence, the sensitivity to the octant of $\theta_{23}$ can be completely lost and this may have serious implications in our understanding of neutrinos from both the experimental and theoretical perspectives.Comment: Brief note added; accepted for publication in Physical Review Letter

Discovery Potential of T2K and NOvA in the Presence of a Light Sterile Neutrino

We study the impact of one light sterile neutrino on the prospective data expected to come from the two presently running long-baseline experiments T2K and NOvA when they will accumulate their full planned exposure. Introducing for the first time, the bi-probability representation in the 4-flavor framework, commonly used in the 3-flavor scenario, we present a detailed discussion of the behavior of the numu to nue and numubar to nuebar transition probabilities in the 3+1 scheme. We also perform a detailed sensitivity study of these two experiments (both in the stand-alone and combined modes) to assess their discovery reach in the presence of a light sterile neutrino. For realistic benchmark values of the mass-mixing parameters (as inferred from the existing global short-baseline fits), we find that the performance of both these experiments in claiming the discovery of the CP-violation induced by the standard CP-phase delta13 equivalent to delta, and the neutrino mass hierarchy get substantially deteriorated. The exact loss of sensitivity depends on the value of the unknown CP-phase delta14. Finally, we estimate the discovery potential of total CP-violation (i.e., induced simultaneously by the two CP-phases delta13 and delta14), and the capability of the two experiments of reconstructing the true values of such CP-phases. The typical (1 sigma level) uncertainties on the reconstructed phases are approximately 40 degree for delta13 and 50 degree for delta14.Comment: 36 pages, 42 pdf figures, 2 tables. Few references added. Accepted in JHE

Cornering the revamped BMV model with neutrino oscillation data

Using the latest global determination of neutrino oscillation parameters from~\cite{deSalas:2017kay} we examine the status of the simplest revamped version of the BMV (Babu-Ma-Valle) model, proposed in~\cite{Morisi:2013qna}. The model predicts a striking correlation between the "poorly determined" atmospheric angle $\theta_{23}$ and CP phase $\delta_{CP}$, leading to either maximal CP violation or none, depending on the preferred $\theta_{23}$ octants. We determine the allowed BMV parameter regions and compare with the general three-neutrino oscillation scenario. We show that in the BMV model the higher octant is possible only at $99\%$ C.L., a stronger rejection than found in the general case. By performing quantitative simulations of forthcoming DUNE and T2HK experiments, using only the four "well-measured" oscillation parameters and the indication for normal mass ordering, we also map out the potential of these experiments to corner the model. The resulting global sensitivities are given in a robust form, that holds irrespective of the true values of the oscillation parameters.Comment: 5 pages, 2 figure

A microRNA feedback loop regulates global microRNA abundance during aging

Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated the network of genes that controls miRNA transcription and processing during C. elegans aging. We found that miRNA biogenesis genes are highly networked with transcription factors and aging-associated miRNAs. In particular, miR-71, known to influence life span and itself up-regulated during aging, represses alg-1/Argonaute expression post-transcriptionally during aging. Increased ALG-1 abundance in mir-71 loss-of-function mutants led to globally increased miRNA expression. Interestingly, these mutants demonstrated widespread mRNA expression dysregulation and diminished levels of variability both in gene expression and in overall life span. Thus, the progressive molecular decline often thought to be the result of accumulated damage over an organism's life may be partially explained by a miRNA-directed mechanism of age-associated decline.</jats:p

Isolation of a transcriptionally active element of high copy number retrotransposons in sweetpotato genome

Many plant retrotransposons have been characterized, but only three families (Tnt1, Tto1 and Tos17) have been demonstrated to be transpositionally competent. We followed a novel approach that enabled us to identify an active element of the Ty1-copia retrotransposon family with estimated 400 copies in the sweetpotato genome. DNA sequences of Ty1 -copia reverse transcriptase (RTase) from the sweetpotato genome were analyzed, and a group of retrotransposon copies probably formed by recent transposition events was further analyzed. 3’RACE on callus cDNA amplified transcripts containing long terminal repeats (LTR) of this group. The sequence -specific amplification polymorphism (S-SAP) patterns of the LTR sequence in the genomic DNA were compared between a normal plant and callus lines derived from it. A callus -specific S-SAP product was found into which the retrotransposon detected by the 3’RACE had been transposed apparently during cell culture. We conclude that our approach provides an effective way to identify active elements of retrotransposons with high copy numbers.</p