Attitude towards tobacco consumption among residents of Dhankuta Municipality of Nepal

The use of tobacco is a major cause of preventable mortality. The estimated number of smokers is 1.1 billion. Of these, 700 million men and 100 million women are in developing countries. The objective of this study was to find out attitude towards tobacco consumption among residents of Dhankuta Municipality. The cross sectional study was conducted among the residents of Dhankuta Municipality where 205 households were taken as subjects. Pretested semi structured questionnaire was administered to the study subjects and face to face interview was conducted. The collected data was entered in MS Excel 2000. The quantitative data was analyzed using Statistical Package for the Social Sciences SPSS software package. The study subjects consist of 50.2 of male and 49.8 of female. Regarding respondent's education, study population showed high level of SLC and above 40.5 followed by below SLC 36.1 and very less was illiterate 14.1 . Majority of the respondents think that there should be ban of the advertising of tobacco products 87.3 and smoking in public places 79 . Almost 67 of respondents think that patient's chances of quitting smoking will be increased if health professionals will give advice to patients. Almost 72.6 of the study population feel cut down tobacco use and 80.3 feel guilty about this habit. Almost 65.8 have tried to discontinue tobacco consumption. We conclude that the residents of Dhankuta reflect good attitude towards cessation of tobacco but poor practice to prevent of tobacco consumption. Dr. Ram Bilakshan Sah | Jha N "Attitude towards tobacco consumption among residents of Dhankuta Municipality of Nepal" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-4 , June 201

Genotype x environment interaction and stability analysis in lentil (Lens culinaris Medik.)

Genotype x environment interaction was evaluated under eight environments during lentil growing season of 2013/14 and 2014/15 for grain yield and their component characters of twenty one promising genotypes selected from previous trial of lentil. The variances estimated due genotype, environment and genotype x environment interaction were found to be different significantly for all the characters studies indicating distinct nature of genotypes, environments and genotype x environment interactions in phenotypic expression. High estimates of sum of square (SS) for all the traits are expressed by environment. The explained percentage of grain yield by environment, genotype and genotype environment interaction were 54.86, 19.86 and 25.28 respectively. To find out the effects of GEI on grain yield and its attributing characters, the data were subjected to Additive Main effects and Multiplicative Interaction (AMMI) .The results finally indicated that AMMI stability value and AMMI biplot are informative methods to explore stability and adaptation pattern of genotypes in practical plant breeding and in subsequent variety recommendations. In addition, finding mega environments help to identify the most suitable lentil cultivars that can be recommended for areas within the mega-environment in either one or more test locations. The genotype RL39 (1.254 mt ha-1 ) and LL10071 (1.196 mt ha-1 ) produced higher grain yield) than all other genotypes over the environments and performed better at most of the places. The genotypes ,F2003-49L, Arun, 39-S-66L, RL-44, and ILL10071 were found to be comparatively stable as their performance were hardly affected by the G x E interaction and thus would perform well across a wide range of environments. These genotypes produced higher grain yield than all checks

Electrochemical strategy for grown ZnO nanoparticles deposited onto HY zeolite with enhanced photodecolorization of methylene blue: Effect of the formation of Si O Zn bonds

Nanoparticles of electrogenerated zinc-supported HY zeolite (EGZnO/HY) catalyst were prepared by a simple electrochemical method. The interaction between zinc species and HY support during the electrolysis was found to affect the EGZnO/HY structure. In addition to the formation of EGZnO nanoparticles (<30 nm in size) that distributed on the surface of HY support, an isomorphous substitution of Al with Zn also occurred in the aluminosilicate framework to result in a Si O Zn bonds. The photoactivity of EGZnO/HY was tested on the decolorization of methylene blue (MB). An amount of 0.375 g L−1 of 1 wt% EGZnO/HY was found to be the optimum dosage for 10 mg L−1 MB, which resulted in 80% of maximum decolorization after 6 h of contact time at pH 3 under fluorescent light (420 nm). Increasing the EGZnO loading led to additional formation of Si O Zn bonds and lessened the number of EGZnO nanoparticles, which then reduced the photodecolorization percentage of MB.The photocatalytic reaction was follows the first-order Langmuir–Hinshelwood model, and gives partially mineralization. The photocatalyst was still stable after five cycling runs with no Zn leaching

Monitoring of organochlorine pesticide residues from bovine milk in Patna (Bihar), INDIA

&nbsp;The milk has high nutritional properties and is widely used as baby food in different forms. The present study was undertaken to evaluate pesticide contamination in bovine milk samples from Patna district of Bihar. Out of 24 samples analyzed during 2012, 18 samples (75 %) were found to be contaminated with HCH residues varying from ND-0.178 mg kg-1 (mean value 0.135 mg kg-1). Seven samples (29.2 %) had HCH exceeding MRL of 0.01 mg kg-1. DDT residues were detected in 20 samples (83.3 %) and ranged from ND-0.132 mg kg-1 (mean value 0.122 mg kg-1). Five samples (20.8 %) contained DDT residues above the prescribed MRL of 0.05 mg kg-1. Out of 24 samples of bovine milk analyzed during 2013, 16 samples (66.7 %) were found to be contaminated with HCH and 15 samples (62.5%) with DDT residues. The residues of HCH varied from ND-0.154 mg kg-1 (mean value 0.053 mg kg-1) and DDT from ND-0.120 mg kg-1 (mean value 0.122 mg kg-1). The residues of HCH and DDT were above MRL in four samples (16.7 %) and three samples (12.5 %) respectively. The management practices of animals and legal punishment on using banned pesticides are the alternatives to reduce pesticide contamination incidences in milk

A simple mathematical model of gradual Darwinian evolution: Emergence of a Gaussian trait distribution in adaptation along a fitness gradient

We consider a simple mathematical model of gradual Darwinian evolution in continuous time and continuous trait space, due to intraspecific competition for common resource in an asexually reproducing population in constant environment, while far from evolutionary stable equilibrium. The model admits exact analytical solution. In particular, Gaussian distribution of the trait emerges from generic initial conditions.Comment: 21 pages, 2 figures, as accepted to J Math Biol 2013/03/1

Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala

The continuum of physiological anxiety up to psychopathology is not merely dependent on genes, but is orchestrated by the interplay of genetic predisposition, gene x environment and epigenetic interactions. Accordingly, inborn anxiety is considered a polygenic, multifactorial trait, likely to be shaped by environmentally driven plasticity at the genomic level. We here took advantage of the extreme genetic predisposition of the selectively bred high (HAB) and low anxiety (LAB) mouse model exhibiting high vs low anxiety-related behavior and tested whether and how beneficial (enriched environment) vs detrimental (chronic mild stress) environmental manipulations are capable of rescuing phenotypes from both ends of the anxiety continuum. We provide evidence that (i) even inborn and seemingly rigid behavioral and neuroendocrine phenotypes can bidirectionally be rescued by appropriate environmental stimuli, (ii) corticotropin-releasing hormone receptor 1 (Crhr1), critically involved in trait anxiety, shows bidirectional alterations in its expression in the basolateral amygdala (BLA) upon environmental stimulation, (iii) these alterations are linked to an increased methylation status of its promoter and, finally, (iv) binding of the transcription factor Yin Yang 1 (YY1) to the Crhr1 promoter contributes to its gene expression in a methylation-sensitive manner. Thus, Crhr1 in the BLA is critically involved as plasticity gene in the bidirectional epigenetic rescue of extremes in trait anxiety

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is important for the cognitive and neurogenic benefits of running. Proteomic analysis revealed elevated levels of CTSB in conditioned medium derived from skeletal muscle cell cultures treated with AMP-kinase agonist AICAR. Consistently, running increased CTSB levels in mouse gastrocnemius muscle and plasma. Furthermore, recombinant CTSB application enhanced expression of brain-derived neurotrophic factor (BDNF) and doublecortin (DCX) in adult hippocampal progenitor cells through a mechanism dependent on the multifunctional protein P11. In vivo, in CTSB knockout (KO) mice, running did not enhance adult hippocampal neurogenesis and spatial memory function. Interestingly, in Rhesus monkeys and humans, treadmill exercise elevated CTSB in plasma. In humans, changes in CTSB levels correlated with fitness and hippocampus-dependent memory function. Our findings suggest CTSB as a mediator of effects of exercise on cognition

Corrigendum: Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

In the original article, there was a mistake in the legend for Figure 4 as published (the spelling of isosilibin was incorrect). The correct legend appears below. In the original article, there was a mistake in Figure 4 as published (CH3 group was missing in the Silybin structure). The corrected Figure 4 appears below. The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way