Passing Learning Results By Applying Pairing Strategies In Football Games

The research is a descriptive quantitative study that aims to determine the learning outcomes of students by applying a paired strategy to students of SDN Mamajang 1 Makassar. The independent variable in this study is to analyze the learning outcomes of soccer passing, while the dependent variable is to determine the results of passing in soccer games using a paired strategy. The population in this study were all fifth grade students of SDN Mamajang 1 Makassar as many as 21 students, Based on the data from the research results, the data analysis obtained the average learning outcomes of passing class V students of SDN Mamajang 1 Makassar of 20.33 showed a good category, then the research data and the classical assumption test and hypothesis testing of the paired passing model obtained data with an average value of 85.48. In accordance with the results of data analysis, it shows that the results of passing learning are supported by the success of the paired passing strategy with a contribution of 82% so that it can be concluded that the application of paired strategies can improve the passing of fifth grade students of SDN Mamajang 1 Makassar

Genetic Polymorphic Impact of Metabolizing Enzyme (CYP3A4 and UGT1A4 genes) on Anastrazole Response in Iraqi Breast Cancer Women

1.1. Background and Objective: Anastrazole is an aromatase inhibitor used widely in therapy of breast cancer and has been metabolized by CYP3A4 and UGT1A4 in liver. Breast cancer is the most common cancer type in worldwide and the second causes of death after lung cancer and the one of therapy that use in its treatment is aromatase inhibiter, anastrazole has been indicated CYP3A1 and UGT1A4 are the main metabolizing enzyme, so the interindividual variation in anastrazole response are due to polymorphism of these gene. We have aimed to determine whether CYP3A4*22 and UGT1A4*2 single nucleotide polymorphisms can have affected on the response of anastrazole. 1.2. Method: 100 Iraqi females with hormone positive breast cancer were included in this study. patients were genotyped for SNPs in the CYP3A1 and UGT1A4 genes to research for response to anastrazole thought measured serum level of estradiol (E2) and tumor marker CA15.3. Highly polymorphic CYP3A4*22 (rs35599367) and UGT1A4*2 (rs6755571) were detected with different genotypes in variable percentage in Iraqi breast cancer women. 1.3. Results: For rs35599367 found that the wild genotype(GG) and for rs6755571 the mutant genotype (TT) were most abounded in 100 breast cancer women and also (AA) another mutant genotype of rs6755571 detected but in low percent. Non –significant association between different detected genotype of both SNPs and serum estradiol level, elevation of serum CA15.3 level and development of arthralgia. 1.4. Conclusion: Both SNPs suggesting had no effect on the serum levels of E2 and CA15.3 and development of arthralgia.</jats:p

Naturalness in Literary Translation

Abstract The present article investigates the concept of naturalness in literary translation. The aim of the investigation is to delineate an integrated approach to 'natural' translation, the essence of which lies in creating a compromise between accurate rendition and literary reproduction. Such a compromise entails attaining an artistic verbal smoothness which transcends the level of ordinary language. To this end, natural translation calls for a utilization of the target language's resources that will make the translation read like an authentic target language (TL) work, while preserving the content intact. The article thus identifies naturalness as the achievement of authentic TL style, and unnaturalness as the hybrid language of literal rendition, i.e. translationese that may be unacceptable or unintelligible. It detects the actualization of an authentic style of Arabic rendition on several levels: lexical, sentential, cohesive and idiomatic. On the lexical level, naturalness is delimited in terms of proper choice of appropriate vocabulary. On the sentential level, well-formedness is posited as the feature of naturalness which outlines a rhetorically natural sentence, besides other concomitant features. On the cohesive level, the features of a natural target text are based on the use of cohesive devices to a greater or lesser degree than the source text in general and on the propriety of their use in particular instances. At the idiomatic level, we mention idioms and proverbs but concentrate, with examples, on collocations. Résumé Cet article examine la notion de naturel dans la traduction des textes littéraires dans le but de cerner une approche intégrée de la traduction 'naturelle' qui consiste essentiellement à obtenir un compromis entre un rendu fidèle et une reproduction littéraire. Ce compromis exige une fluidité verbale artistique qui dépasse le niveau de la langue ordinaire. La traduction naturelle doit donc utiliser toutes les ressources de la langue d'arrivée pour que la traduction se lise comme ouvrage littéraire rédigé dans cette langue d'arrivée, tout en respectant fidèlement le contenu. Dans leur article, les auteurs définissent donc le naturel comme l'obtention d'un style authentique dans la langue d'arrivée, et le manque de naturel comme un langage hybride avec un rendu littéral, c'est-à-dire des traductions susceptibles d'être inacceptables ou incompréhensibles. L'article analyse comment mettre en oeuvre, à différents niveaux, un style authentique en arabe: lexicologie, phraséologie, cohérence et usage d'expressions idiomatiques. En ce qui concerne le niveau lexicologique, le naturel se définit comme étant le choix correct d'un vocabulaire approprié. Au niveau phraséologi-que, des phrases formées correctement sont la caractéristique du naturel qui fait apparaître, à côté d'autres propriétés, la rhétorique naturelle de la phrase. Au niveau de la cohérence, les caractéristiques d'un texte rédigé avec naturel dans la langue cible sont basées sur des mécanismes utilisés plus ou moins intensivement que dans le texte d'origine en général et sur leur utilisation appropriée dans certains cas particuliers. Au niveau des expressions idiomatiques, les auteurs mentionnent de telles expressions ainsi que des proverbes, mais se concentrent, en donnant des exemples, sur des collocations.</jats:p

Prognostic Value of Malondialdehyde Serum Levels in Severe Sepsis: A Multicenter Study

OBJECTIVE: The oxidant/antioxidant state in septic patients has only been studied in small series. We wished to determine whether malondialdehyde (MDA) serum levels were associated with severity and 30-day mortality in a large series of patients with sepsis. METHODS: We performed an observational, prospective, multicenter study in six Spanish Intensive Care Units. Serum levels of MDA were measured in a total of 228 patients (145 survivors and 83 non-survivors) with severe sepsis and 100 healthy controls. RESULTS: Serum levels of MDA were higher in severe septic patients than in healthy controls. Non-surviving septic patients had higher MDA values than survivors. MDA serum levels were associated with severity markers (lactic acid, SOFA, APACHE-II) and coagulation indices. Regression analysis showed that MDA serum levels were associated with 30-day survival (Hazard ratio = 1.05; 95% confidence interval = 1.009–1.091; p = 0.016). Receiver operating characteristic analysis showed that the area under curve of MDA serum levels to predict 30-day survival was 0.62 (95% CI = 0.56–0.69; P = 0.002). The risk of death in septic patients with MDA serum levels above 4.11 nmol/mL was higher than in patients with lower values (Hazard Ratio = 2.43; 95% CI = 1.49–3.94; p<0.001). CONCLUSIONS: The novel findings of our study on severe septic patients, to our knowledge the largest series providing data on the oxidative state, are that elevated MDA serum levels probably represent an unbalanced oxidant state and are related with poor prognosis in patients with severe sepsis