11,301 research outputs found

    Identifikasi Titik Kemacetan dan Alternatif Penanganannya di Kecamatan Pontianak Timur, Pontianak Selatan, Pontianak Tenggara

    Full text link
    Growth and development of the city have an impact on the problem of traffic systems. The impact associated with the influence of road capacity and traffic volume, which can cause traffic congestion problem. From 3 districts who studied the East Pontianak, Pontianak South, Southeast Pontianak there are 9 point jam, and 2 of them experienced severe congestion that is the intersection of Jalan Sultan Hamid II - Jalan Imam snag - Way Hero - Road Tanjungpura and U-Turn at the next gas station OSO segment Ahmad Yani street. The purpose of this paper is to identify the point - the point of congestion and causes congestion in the districts East Pontianak, Pontianak South, and Southeast Pontianak so may submit management plans and programs of action plans that can be done to address the problem of traffic congestion in the district of East Pontianak, South Pontianak, Pontianak and Southeast for now. In this study, the data obtained by several agencies that BPS and POLRESTA city of Pontianak. The survey has been carried out, namely traffic volume survey conducted on Sunday (17 November 2013), on Monday (18 November 2013), in the morning at 6:00 a.m. to 9:00, lunch at 11:00 to 14:00, afternoon at 4:00 p.m. to 18:00 pm. The geometric survey conducted on Sunday (24 November 2013) .From these survey results taken 2 points were considered to be the most severe congestion that will be calculated and analyzed so that it will acquire the capacity and degree of saturation. The degree of saturation can be used as an indicator of the level of performance of an intersection and road segment. Where the degree of saturation can directly determine the performance of a road. Based on Indonesian Highway Capacity Manual for urban roads in 1997, requires the degree of saturation does not exceed 0.85. Based on the results obtained in 2013 the degree of saturation at Jalan Sultan Hamid II is 0.87, Jalan Imam Bonjol of 0.95, 0.70 at Jalan Pahlawan, Jalan Tanjungpura of 0.89 and a U-Turn at the next gas station OSO road Ahmad Yani direction Roundabout to Untan ie 0:56, 0:57 direction to the PCC that although the degree of saturation of <0.85 but the area can be said to be congested due to the long queue of vehicles that will pass through the U-Turn, disrupt traffic flow on the road Ahmad Yani. This indicates that in 2013 the 2 point of congestion experienced traffic problems. For those reasons, given the alternative solution is to operationalize back Public Transport Buses in particular, so as to reduce the degree of saturation in the region studied

    Reconciliation of object interaction models

    Get PDF
    This paper presents Reconciliation+, a tool-supported method which identifies overlaps between models of different object interactions expressed as UML sequence and/or collaboration diagrams, checks whether the overlapping elements of these models satisfy specific consistency rules, and guides developers in handling these inconsistencies. The method also keeps track of the decisions made and the actions taken in the process of managing inconsistencies

    Understanding the in vivo Uptake Kinetics of a Phosphatidylethanolamine-binding Agent \u3csup\u3e99m\u3c/sup\u3eTc-Duramycin

    Get PDF
    Introduction 99mTc-Duramycin is a peptide-based molecular probe that binds specifically to phosphatidylethanolamine (PE). The goal was to characterize the kinetics of molecular interactions between 99mTc-Duramycin and the target tissue. Methods High level of accessible PE is induced in cardiac tissues by myocardial ischemia (30 min) and reperfusion (120 min) in Sprague–Dawley rats. Target binding and biodistribution of 99mTc-duramycin were captured using SPECT/CT. To quantify the binding kinetics, the presence of radioactivity in ischemic versus normal cardiac tissues was measured by gamma counting at 3, 10, 20, 60 and 180 min after injection. A partially inactivated form of 99mTc-Duramycin was analyzed in the same fashion. A compartment model was developed to quantify the uptake kinetics of 99mTc-Duramycin in normal and ischemic myocardial tissue. Results 99mTc-duramycin binds avidly to the damaged tissue with a high target-to-background radio. Compartment modeling shows that accessibility of binding sites in myocardial tissue to 99mTc-Duramycin is not a limiting factor and the rate constant of target binding in the target tissue is at 2.2 ml/nmol/min/g. The number of available binding sites for 99mTc-Duramycin in ischemic myocardium was estimated at 0.14 nmol/g. Covalent modification of D15 resulted in a 9-fold reduction in binding affinity. Conclusion 99mTc-Duramycin accumulates avidly in target tissues in a PE-dependent fashion. Model results reflect an efficient uptake mechanism, consistent with the low molecular weight of the radiopharmaceutical and the relatively high density of available binding sites. These data help better define the imaging utilities of 99mTc-Duramycin as a novel PE-binding agent

    Excitonic quasiparticles in a spin-orbit Mott insulator

    Full text link
    In condensed matter systems, out of a large number of interacting degrees of freedom emerge weakly coupled particles, in terms of which most physical properties are described. For example, Landau quasiparticles (QP) determine all electronic properties of a normal metal. The lack of identification of such QPs is major barrier for understanding myriad exotic properties of correlated electrons, such as unconventional superconductivity and non-Fermi liquid behaviours. Here, we report the observation of a composite particle in a Mott insulator Sr2IrO4---and exciton dressed with magnons---that propagates with the canonical characteristics of a QP: a finite QP residue and a lifetime longer than the hopping time scale. The dynamics of this charge-neutral bosonic excitation mirrors the fundamental process of the analogous one-hole propagation in the background of ordered spins, for which a well-defined QP has never been observed. The much narrower linewidth of the exciton reveals the same intrinsic dynamics that is obscured for the hole and is intimately related to the mechanism of high temperature superconductivity.Comment: submitted versio

    The relationship between infecting organisms and underlying structural anomalies in children with urinary tract infections

    Get PDF
    Introduction: Urinary tract infections (UTIs) are a common cause of morbidity in childhood with potential for renal scarring and reflux nephropathy which can lead to hypertension and end-stage renal failure. Aim: The aim of this study was to investigate the relationship between the infecting organism and any underlying anomalies of the urinary tract which may predispose to the development of infections and which may alter the management of children with UTIs. Methods and results: A total of 72 cases of UTI were recorded retrospectively (in- and outpatients), with ages ranging from 3 days to 48 months (mean 9.5, median 5 months). Fifty seven (79%) of patients had their first reported urinary tract infection under the age of 1 year.. Fifty eight (80.6%) were E. coli infections. These presented at an older age than non-E. coli infections. Investigations were abnormal in 31 (43%) cases. The mean age for first infection in patients with abnormal investigations was 7.7 months (median 2 months), younger than those with no renal tract abnormalities. Organisms other than E. coli were rarely found when no significant abnormalities were detected with investigation by US and MCUG and this was a statistically significant difference (p<0.001). Renal scarring was identified in 10 (13.9%) patients. Discussion: This study confirms that non-E. coli UTI is associated with underlying renal pathology and that early infections with any organism are more likely to be associated with underlying abnormalities. We also outline an algorithm based on the recent NICE 2007 guidelines which will be adopted by the Paediatric Department, Mater Dei Hospital for the investigation of UTI.peer-reviewe

    Perancangan Pengolahan Air Minum Tenaga Surya Kapasitas 50 M3/hari (dengan Menggunakan Proses Biofiltrasi dan Ultrafiltrasi)

    Full text link
    Drinking water supply for public is big deals for the improvement of environmental and society health. An effort from the government to provide the drinking water supply is to provide a society based of drinking water treatment plant. Some obstacles that have come for the plant in remote areas are the difficulties of getting chemical material for the plant and the lack of energy supply. Drinking water treatment that use chemical materials has a big cost to provide the chemicals. Beside the high cost of treatment, the using of chemicals will harmful the drinking water, because it usually generates such carcinogenic materials. The biofiltration-ultrafiltration treatment is one of the best solutions to replace treatment plant that using chemicals. It has a low cost operation and is more safe than the water treatment that using chemicals. Generator-set (genset), a power generator that easy to get and operate, has uneconomical operation cost. By now, there were many studies proved that in remote areas, the using of Solar Power Plant is more economic than a genset. For those reasons, in this article is designed a solar powered 50 m3/Day drinking water treatment (biofiltration-ultrafiltration process). The result from the design is the solar power plant that can supply the treatment plant for 8 hours

    Phase diagram for nanostructuring CaF2_2 surfaces by slow highly charged ions

    Full text link
    Impacts of individual slow highly charged ions on alkaline earth halide and alkali halide surfaces create nano-scale surface modifications. For different materials and impact energies a wide variety of topographic alterations have been observed, ranging from regularly shaped pits to nano-hillocks. We present experimental evidence for a second threshold for defect creation supported by simulations involving the initial electronic heating and subsequent molecular dynamics. From our findings a unifying phase diagram underlying these diverse observations can be derived. By chemically etching of CaF2_2 samples after irradiation with slow highly charged ions both above and below the potential energy threshold for hillock formation another threshold exists above which triangular pits are observed after etching. This threshold depends on both the potential and kinetic energies of the incident ion. Simulations indicate that this second threshold is associated with the formation of defect aggregates in the topmost layers of CaF2_2

    Morogoro Regional and District Projections

    Get PDF
    \ud This report presents population projections for the period 2003 to 2025 for the Morogoro Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and migration were projected separately as well as HIV/AIDS prevalence. The projected components were then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, and shows Morogoro’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. Population growth for the period 2003 to 2025 shows a decrease in growth rates. The projections show that population growth rate will decrease from 2.3 percent in 2003 (with a population of 1,794,815) to 1.7 percent in 2025 (with a population of 2,818,784). Sex Ratio at birth is projected to increase from 99 male births per 100 females in 2003 to 101 male births per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 105 deaths per 1,000 live births in 2003 to 63 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 171 deaths per 1,000 live births in 2003 to 98 deaths per 1,000 live births in the year 2025. The mortality projected estimates further show that the life expectancy at birth for males is slightly lower compared to that of females. Life expectancy at birth for Morogoro will increase from 50 years in 2003 to 54 years in 2025 for both sexes. For male population, life expectancy at birth will increase from 50 years in year 2003 to 54 years in 2025, while for female population, the life expectancy at birth will increase from 50 years in 2003 to 55 years in 2025. On fertility, TFR will decline from 5.0 children per woman in 2003 to 3.7 children per woman in 2025.\u

    Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide

    Get PDF
    Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem. Inflammatory responses to infections are reproduced by lipopolysaccharide (LPS) engaging Toll-like receptor 4 (TLR4). Apoptosis is a hallmark of lung injury in sepsis. This study was conducted to determine whether preexposure to LPS or hypoxia modulated the survival of pulmonary artery endothelial cells (PAECs). We also investigated the role TLR4 receptor expression plays in apoptosis due to these conditions. Bovine PAECs were cultured in hypoxic or normoxic environments and treated with LPS. TLR4 antagonist TAK-242 was used to probe the role played by TLR4 receptors in cell survival. Cell apoptosis and survival were measured by caspase 3 activity and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) incorporation. TLR4 expression and tumor necrosis factor α (TNF-α) production were also determined. LPS increased caspase 3 activity in a TAK-242-sensitive manner and decreased MTT incorporation. Apoptosis was decreased in PAECs preconditioned with hypoxia prior to LPS exposure. LPS increased TNF-α production, and hypoxic preconditioning blunted it. Hypoxic preconditioning reduced LPS-induced TLR4 messenger RNA and TLR4 protein. TAK-242 decreased to baseline the LPS-stimulated expression of TLR4 messenger RNA regardless of environmental conditions. In contrast, LPS followed by hypoxia substantially increased apoptosis and cell death. In conclusion, protection from LPS-stimulated PAEC apoptosis by hypoxic preconditioning is attributable in part to reduction in TLR4 expression. If these signaling pathways apply to septic patients, they may account for differing sensitivities of individuals to acute lung injury depending on oxygen tensions in PAECs in vivo
    corecore