KONTEKSTUALISASI KITAB KUNING: UPAYA MEMBANGUN INDONESIA YANG MULTIKULTUR

Penelitian ini menggunakan pendekatan Fenomenologi, yakni penelitian yang mengungkap fakta dalam suatu rentang waktu tertentu berdasarkan pandangan sekelompok orang atau seseorang yang dianggap representatif. Penulisan dilakukan dengan deskriptif eksploratif, dan analisis dilakukan secara kualitatif. Pengumpulan data selain dilakukan melalui studi pustaka, penelitian juga dilakukan dengan observasi partisipasi, wawancara mendalam, dan penelitian melalui situs web. Temuan dalam penelitian ini adalah pertama adanya dinamika pemikiran kalangan Muda Nahdlatul Ulama bergerak secara radikal bila diukur dari akar budaya pemikiran pendahulunya, dari Tradisionalisme Konservatif menjadi Tradisionalisme Radikal. Kedua, gerakan kalangan Muda Nahdlatul Ulama dilakukan melalui proses dekonstruksi bagi rekonstruksi. Basil pembacaan realitas menghasilkan rekonstruksi pemikiran agama, diaplikasikan dalam gerakan bagi penguatan masyarakat sipil, atau Mabady Khaira Ummah dalam konsep Nahdlatul Ulama. Ketiga, Kitab Kuning yang selama ini menjadi landasan Ideologi Ahlussunnah Wal Jamaah, dalam gerakan dan pemikiran kalangan Muda Nahdlatul Ulama, posisi Kitab Kuning mengalami proses desakralisasi dan kontekstualisasi, untuk menjadikan warga Nahdliyyin toleran terhadap perbedaan pemikiran, agama dan budaya. Keempat, konflik-konflik internal yang terjadi antar etnis, antar agama dan antar golongan bersumber dari landasan ideologi yang intoleran. Kontekstualisasi Kitab Kuning merupakan salah satu jalan untuk memberikan landasan ideologi yang lebih terbuka, toleran dan ramah, bagi terciptanya kondisi Indonesia yang lebih damai dalam keragaman

Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing.

Touch sensation hinges on force transfer across the skin and activation of mechanosensitive ion channels along the somatosensory neurons that invade the skin. This skin-nerve sensory system demands a quantitative model that spans the application of mechanical loads to channel activation. Unlike prior models of the dynamic responses of touch receptor neurons in Caenorhabditis elegans (Eastwood et al., 2015), which substituted a single effective channel for the ensemble along the TRNs, this study integrates body mechanics and the spatial recruitment of the various channels. We demonstrate that this model captures mechanical properties of the worm's body and accurately reproduces neural responses to simple stimuli. It also captures responses to complex stimuli featuring non-trivial spatial patterns, like extended or multiple contacts that could not be addressed otherwise. We illustrate the importance of these effects with new experiments revealing that skin-neuron composites respond to pre-indentation with increased currents rather than adapting to persistent stimulation

Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome

Hydralazine, a vasodilator, is commonly used as an adjunctive treatment for moderate to severe hypertension, heart failure and hypertensive emergencies in pregnancy. Hydralazine-induced lupus was first described in 1953. Clinical presentation ranges from arthralgia, myalgia, petechiae, or rash to single or multiorgan involvement. An occurrence of systemic vasculitis is a rare complication. When presented as the pulmonary-renal syndrome, it could have a rapidly progressive course which can be fatal. Here, we describe a case of hydralazine-associated rapidly progressive glomerulonephritis and pulmonary haemorrhage. We use this case to review the current literature and discuss and highlight the importance of a high degree of clinical acumen, early diagnosis and prompt treatment for better clinical outcomes

Collagen 1 fibers and hypoxic tumor microenvironments in breast cancer and their effect on transport of molecules within the tumor matrix

The work presented in this thesis represents a culmination of four years of research work focused on understanding the role of collagen I (Col1) fibers, a major component of the tumor extracellular matrix in breast cancer. We have investigated the relationship of Col1 fibers with metastasis, hypoxia, macromolecular transport, water diffusion and fractional anisotropy using clinical breast cancer specimens and human breast cancer xenografts genetically engineered to fluoresce under hypoxia. The thesis describes in the detail of the rationale, study design, results and discussion for our studies, which have been either published or submitted as four separate papers. The work here also presents multimodal in vivo imaging techniques which could be used clinically for non-invasive diagnoses of breast cancer progression. These techniques will help provide better patient management

Identification Of Proteins Regulating Vldl Sorting Into The Vldl Transport Vesicle (vtv) And Involved In The Biogenesis Of The Vtv

Increased secretion of very low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein, by the liver causes hypertriglyceridemia, which is a major risk factor for the development of atherosclerosis. The rate of VLDL-secretion from the liver is determined by its controlled transport from the endoplasmic reticulum (ER) to the Golgi. The ER-to-Golgi transport of newly synthesized VLDL is a complex multi-step process and is mediated by the VLDL transport vesicle (VTV). Once a nascent VLDL particle is synthesized in the lumen of the ER, it triggers the process of VTV-biogenesis and this process requires coat complex II (COPII) proteins that mediate the formation of classical protein transport vesicles (PTV). Even though, both VTV and PTV bud off the same ER at the same time and require the same COPII proteins, their cargos and sizes are different. The VTV specifically exports VLDL to the Golgi and excludes hepatic secretory proteins such as albumin and the size of the VTV is larger (~ 100 -120 nm) than PTV to accommodate VLDL-sized particles. These observations indicate (i) the existence of a sorting mechanism at the level of the ER; and (ii) the involvement of proteins in addition to COPII components. This doctoral thesis is focused on identification of proteins regulating VLDL sorting into the VTV and involved in the biogenesis of the VTV. In order to identify proteins present exclusively in VTV, we have characterized the proteome of VTV, which suggest CideB (cell death-inducing DFF45-like effector b) and SVIP (small VCP/P97 interacting protein) as candidates, present in VTV but excluded from PTV. We further confirmed the finding by performing co-immunoprecipitation studies and confocal microscopy studies. CideB, a 26-kDa protein was found to interact with apolipoprotein iv B100 (apoB 100), the structural protein of VLDL. Moreover, CideB interacts with two of the COPII components, Sar1 and Sec24. VTV generation was examined after blocking CideB by specific antibodies and by silencing CideB in rat primary hepatocytes. Knockdown of CideB in primary hepatocytes showed significant reduction in VTV generation, however, CideB was concentrated in VTV as compared with the ER suggesting its functional role in the sorting of VLDL into the VTV. SVIP, a small (~ 9-kDa) protein was found to interact with Sar1, a COPII component that initiates the budding of vesicles from ER membrane. SVIP has sites for myristoylation and we found increased recruitment of SVIP on ER membrane upon myristic acid (MA) treatment. Sar1 that lacks sites for myristoylation also is recruited more on ER upon myristoylation indicating that SVIP promotes Sar1 recruitment on ER. Additionally, our data suggest that Sar1 interacts with SVIP and forms a multimer that facilitates the biogenesis of VTV. Interestingly, silencing of SVIP reduced the VTV generation significantly. Conversely, incubation with MA increased the VTV budding, suggesting recruitment of SVIP on ER surface facilitates the VTV budding. We conclude that SVIP recruits Sar1 on ER membrane and makes an intricate COPII coat leading to the formation of a large vesicle, the VTV. Overall, the data presented in this thesis, determines the role of CideB and SVIP in regulating VLDL sorting and VTV biogenesis

Brain segmentation using endogenous contrast mechanism using breath holding fMRI signal for tissue characterization

MRL has fast become the modality of choice for the analysis of the complexity of the human brain. MRJ is a non-invasive method and gives high spatial resolution maps of the brain with soft tissue contrast. Conventional MRI technique modified to be used to image the functionality at high temporal resolution is known as fMRI. In fMRI the BOLD signal we measure is the hemodynamic response to neuronal and vascular changes at rest or in response to a stimulus where the various tissue types will have a different response. While fMRI has been traditionally been used to detect and identify eloquent regions of the cortex corresponding to specific tasks/stimulus, a number of groups have also used tMRI to study cerebrovascular changes and its consequence on the BOLD signal. A number of different perturbation methods including breath holding, hypercapnia, inhalation of various gas mixtures, and injection of acetozolamyde has been used to study spatio-temporal changes in the fMRI signal intensity. Spatiotemporal changes corresponding to changes in cerebral blood flow (CBF), cerebral blood volume (CBV), oxygen extraction fraction (OEF), and other physiological factors are then estimated and differences between diseased regions and healthy regions are then elucidated

COVID-19 And Nepal: A Gender Perspective

The ongoing Corona Virus Disease 19 (COVID-19) pandemic is in its height, the measures taken to control the spread of this pandemic is acute and harsh. With the increasing new cases every hour it has caused a panic among every individual. Economy of the countries are equally affected. However, the direct and indirect impactof this pandemic on gender related needs are least prioritized and discussed. Evidences so far reveal the mortality being proportionately higher in males.This fact may not remain the same in Nepalese context becausewomen are more vulnerable in this low-income country where limited resources are allotted to women’s health. Majority of the workforce at frontline health care are women in the form of nurses, midwives and female community health volunteers (FCHV). Government of Nepal has decided to mobilize FCHVs for COVID-19 response in the community and these FCHVs who provide services at ground levels are at occupational risk of acquiring the infection

Reproductive Health Issues and Use of Family Planning Methods among Married Adolescent Mothers

Introduction: Adolescent pregnancy is a major public health concern in low- and middle-income countries. Nepal ranks among the twenty countries with the highest child marriage rates in the world. Adolescent mothers are at higher risk for poorer maternal and neonatal outcomes. This study intended to find the reproductive health issues and use of family planning methods among married adolescent mothers at a tertiary care center in a western part of Nepal. Methods: This was a cross-sectional study conducted among adolescent mothers who attended the family planning counseling session at Community Medicine Out-patient Department at a tertiary care center. Pre-tested semi-structured questionnaire was used for data collection and variables were entered in SPSSTM version 16. Descriptive statistics were presented in terms of mean and percentage. Results: Among 235 adolescent mothers, the mean age of adolescent mothers was 18.02 years (SD = 1.13). Almost 93.2% had not used any kind of contraceptive methods previously. Limited knowledge, uncomfortable talking about contraception and spousal denial were common reasons for not using contraception. Obstetric related complications were observed in 13.6% and one in ten neonates required neonatal intensive care unit admission during the study period. After the counseling session, six out of ten expressed current choice of long-acting reversible contraceptives method in which Jadelle implant was preferred. Conclusion: Our study among the adolescent mothers showed that use of family planning methods before pregnancy had been very low. Policies need to focus on meeting the unmet need for family planning among married adolescent girls