Оценка прогностической значимости маркеров грибовидного микоза

Micosis fungoides is a primary skin lymphoma characterized with indolent disease course and favorable prognosis. Опіу at some patients one can observe aggressive development of the disease to malignant stage with the exracutaneous outspread. the modern data about the prognostic factors are presented in the review. Disclosure of these factors allows to forecast the course of disease. there is given attention to integral estimation of survival rates on the ground of tNMB-staging sand estimation of the CUP-index. Definition of combination of different prognostic factors would allow to create prognostic models enabling to diagnose on the early stages of disease the patients with high risk of progression of mycosis fungoides.Грибовидный микоз - первичная лимфома кожи, характеризующаяся индолентным течением и благоприятным прогнозом, и только у небольшой части пациентов наблюдается агрессивное развитие с переходом в опухолевую стадию и внекожным распространением процесса. В обзоре представлены современные сведения о прогностических факторах, обнаружение которых позволит предсказать течение заболевания. Уделено внимание суммарной оценке показателей выживаемости на основании проведения TNMB-стадирования и расчета CLIP-индекса. Определение комбинации различных прогностических факторов позволит создать прогностические модели и на их основе выявлять пациентов с высоким риском прогрессии грибовидного микоза на ранних стадиях заболевания

FACTORS INFLUENCING THE COMPLEXITY OF CONSTRUCTION OF DEPARTMENTAL MOTORWAYS

When planning the construction of a forest road and choosing its rational position on the ground, engineer is constantly faced with the need to take into account the features of the relief, climate, physical and geographical processes and phenomena, surface and underground waters, soil, vegetation, and human economic activity, as factors determining the first first of all, the cost of the construction of a forest road. A correlation analysis carried out for all the arguments has made it possible to establish the most important characteristics of the components of the geographic environment that affect the complexity of constructing a timber road by cost type. The state of theoretical research in the field of construction of departmental motorways has been thoroughly reviewed and analyzed. The analysis made it possible to outline the goals, objectives and general methodology for determining the cost of building roads, depending on the type of work, as well as varying degrees of complexity of road construction, the value of natural resources, and the specific qualities of the territory in the area of the road. The presented results and dependencies may be the basis for determining the basic cost of road construction</jats:p

Assessment of prognostic predictive value at the mycosis fungoides

Micosis fungoides is a primary skin lymphoma characterized with indolent disease course and favorable prognosis. Опіу at some patients one can observe aggressive development of the disease to malignant stage with the exracutaneous outspread. the modern data about the prognostic factors are presented in the review. Disclosure of these factors allows to forecast the course of disease. there is given attention to integral estimation of survival rates on the ground of tNMB-staging sand estimation of the CUP-index. Definition of combination of different prognostic factors would allow to create prognostic models enabling to diagnose on the early stages of disease the patients with high risk of progression of mycosis fungoides

EVALUATION OF HUMAN NATURAL CONDITIONS AND ECONOMIC ACTIVITIES IN THE AREA OF PROPOSED CONSTRUCTION OF A TRUCK HAUL ROAD

At the present stage of development of our country with the widespread use of innovative methods, it is necessary to conduct a comprehensive assessment in order to solve complex problems. The presented article contains evidence of the need for a comprehensive assessment of the natural and man-made conditions for the construction of logging road. The developed methodology for integrated assessment can significantly simplify the process of choosing a rational location of the route and eliminate the intuitive approach to solving this problem. When conducting a comprehensive assessment, the route of the designed logging road is plotted on the cartographic diagrams, and the environmental conditions and human economic activities in the survey area are assessed. The proposed technique allows you to easily and consistently analyze the features of natural and technogenic conditions in the area of logging road construction. An analysis of the main components of the landscapes enables to draw conclusions about the conditions of humidification, the height of the snow cover, the number of days in a year with snowstorms, the relief of the area where the forest road was laid, physical and geological phenomena, characteristics of soil conditions, characteristics of population density, the location of unique natural complexes and the total complexity of road construction conditions. The complexity indicator for the logging road construction reflects the degree of influence of natural conditions, human economic activity and the value of the territories. The methodology presented in the article helps to determine the rational location of the forest road route by assessing the impact of natural conditions and human economic activity on local territories - micro-landscapes, each of which is a natural complex with varying complexity of road construction conditions and land value. The proposed comprehensive assessment enables to compare microlandscapes by the complexity of road construction and find the areas most favorable for logging road construction. A forest road constructed within micro-landscapes with a minimum complexity will meet economic and environmental requirements. The minimum value of the final indicator characterizes the micro landscape with the most favorable conditions for logging road construction. The maximum value of the final complexity indicator characterizes micro-landscapes with the most unfavorable conditions for the construction of a logging road. When choosing the option of laying the route of a forest road, a comparison is proposed to be made according to the weighted average indicator of the complexity of road construction, the average weighted indicator of the value of occupied land and the average weighted total indicator of the complexity of road construction. Indicators of the complexity of logging road construction make it possible to determine the cost of construction by the main types of costs for every road landscape.</jats:p

Pyoderma Faciale — from Clinical Practice

This article considers the clinical observation of the patient with rare and severe form of dermatosis — pyoderma faciale. The effectiveness of systemic corticosteroids with the gradual addition of the oral isotretinoin has been shown. Data on clinical features of this atypical form is provided

Assessment of prognostic predictive value at the mycosis fungoides

Micosis fungoides is a primary skin lymphoma characterized with indolent disease course and favorable prognosis. Опіу at some patients one can observe aggressive development of the disease to malignant stage with the exracutaneous outspread. the modern data about the prognostic factors are presented in the review. Disclosure of these factors allows to forecast the course of disease. there is given attention to integral estimation of survival rates on the ground of tNMB-staging sand estimation of the CUP-index. Definition of combination of different prognostic factors would allow to create prognostic models enabling to diagnose on the early stages of disease the patients with high risk of progression of mycosis fungoides.</jats:p

Mathematical models to determine the influence of road parameters and conditions on vehicular speed

Abstract The study of vehicular movement modes in adverse weather conditions allowed defining the dependence of traffic modes at certain road segments on weather conditions. It is found that the average vehicle speed changes within a year over a wide range depending on road conditions even on its straight horizontal sections. There is a considerable difference in the maximum speed of traffic movement. Complex road sections significantly influence the traffic mode during any period of the year, especially in adverse weather conditions. The road surface condition exerts the greatest impact on the traffic speed. If the adhesion coefficient equals 0.2-0.3 the average traffic speed is 20-25% lower than if that adhesion coefficient equals 0.5-0.6, and in ice conditions the average traffic speed decreases by 40-50%. The proposed calculation formula allows defining the influence of weather conditions on the traffic mode of free-moving cars or cars in a joint traffic flow. It provides for the feasibility study regarding measures aimed to increase the traffic speed in adverse weather conditions of the year. Based on the observations and calculations the correlation dependences of average and maximum traffic speeds on the adhesion coefficient within a 7.0 m-wide road without the hard shoulder were obtained.</jats:p