EfficientNet Algorithm for Classification of Different Types of Cancer

Accurate and efficient classification of different types of cancer is critical for early detection and effective treatment. In this paper, we present the results of our experiments using the EfficientNet algorithm for classification of brain tumor, breast cancer mammography, chest cancer, and skin cancer. We used publicly available datasets and preprocessed the images to ensure consistency and comparability. Our experiments show that the EfficientNet algorithm achieved high accuracy, precision, recall, and F1 scores on each of the cancer datasets, outperforming other state-of-the-art algorithms in the literature. We also discuss the strengths and weaknesses of the EfficientNet algorithm and its potential applications in clinical practice. Our results suggest that the EfficientNet algorithm is well-suited for classification of different types of cancer and can be used to improve the accuracy and efficiency of cancer diagnosis

Thrombectomy in stroke patients with low Alberta Stroke Program Early Computed Tomography Score: Is modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 superior to mTICI 2b?

BACKGROUND AND PURPOSE: Outcomes following mechanical thrombectomy (MT) are strongly correlated with successful recanalization, traditionally defined as modified Thrombolysis in Cerebral Infarction (mTICI) ≥2b. This retrospective cohort study aimed to compare the outcomes of patients with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS; 2-5) who achieved mTICI 2b versus those who achieved mTICI 2c/3 after MT. METHODS: This study utilized data from the Stroke Thrombectomy and Aneurysm Registry (STAR), which combined databases from 32 thrombectomy-capable stroke centers between 2013 and 2023. The study included only patients with low ASPECTS who achieved mTICI 2b, 2c, or 3 after MT for internal carotid artery or middle cerebral artery (M1) stroke. RESULTS: Of the 10,229 patients who underwent MT, 234 met the inclusion criteria. Of those, 98 (41.9%) achieved mTICI 2b, and 136 (58.1%) achieved mTICI 2c/3. There were no significant differences in baseline characteristics between the two groups. The 90-day favorable outcome (modified Rankin Scale score: 0-3) was significantly better in the mTICI 2c/3 group than in the mTICI 2b group (adjusted odds ratio 2.35; 95% confidence interval [CI] 1.18-4.81; P=0.02). Binomial logistic regression revealed that achieving mTICI 2c/3 was significantly associated with higher odds of a favorable 90-day outcome (odds ratio 2.14; 95% CI 1.07-4.41; P=0.04). CONCLUSION: In patients with low ASPECTS, achieving an mTICI 2c/3 score after MT is associated with a more favorable 90-day outcome. These findings suggest that mTICI 2c/3 is a better target for MT than mTICI 2b in patients with low ASPECTS

The Cyclodextrin Glycosyltransferase of Paenibacillus pabuli US132 Strain: Molecular Characterization and Overproduction of the Recombinant Enzyme

The gene encoding the cyclodextrin glycosyltransferase (CGTase) of Paenibacillus pabuli US132, previously described as efficient antistaling agent and good candidate for cyclodextrins production, was cloned, sequenced, and expressed in Escherichia coli. Sequence analysis showed that the mature enzyme (684 amino acids) was preceded by a signal peptide of 34 residues. The enzyme exhibited the highest identity (94%) to the β-CGTase of Bacillus circulans no. 8. The production of the recombinant CGTase, as active form, was very low (about 1 U/mL) in shake flasks at 37°C. This production reached 22 U/mL after 22 hours of induction by mainly shifting the postinduction temperature from 37 to 19°C and using 2TY instead of LB medium. High enzyme production (35 U/mL) was attained after 18 hours of induction in fermentor using the same culture conditions as in shake flask. The recombinant enzyme showed Vmax and Km values of 253 ± 36 μmol of β-cyclodextrin/mg/min and 0.36 ± 0.18 g/L, respectively

Right heart thrombus-in-transit with pulmonary embolism in a patient with primary hypercoagulable state

A 25 year-old female with a history of Caesarian section ten weeks ago presented with symptoms suggestive of pulmonary embolism. Transthoracic echocardiography revealed a free- -floating large thrombus traversing the right atrial cavity. Transesophageal echocardiography confirmed the presence of an unattached thrombus that originated from the most proximal part of the inferior vena cava. Multi-slice computed tomography of the chest and abdomen revealed the thrombus to start from the intra-hepatic part of the inferior vena cava and extend through the right atrium. It also demonstrated multiple thrombi in the pulmonary vasculature, the largest being in the right main pulmonary artery and its lower lobe branch. The patient was triaged for surgical embolectomy under cardio-pulmonary bypass. Follow-up trans-thoracic and transesophageal echocardiography confirmed adequate removal of the thrombus. By genetic examination, she proved to have factor V ’Leiden’ gene and two thrombophilia genes, all of which were positive in the heterozygous state. She had also a high serum homocysteine. (Cardiol J 2010; 17, 4: 408-411

Effect of Soft Tissue Mobilization on Cervical Pain in Nursing Women

Introduction: cervical pain in nursing women is aserious health problem because it certainly limits function and capacity in both work and personal life. Purpose: This study was performed to determine the effectiveness of soft tissue mobilization on the treatment of cervical pain in nursing women. Subjects: sixty breastfeeding women were selected from Fakous Hospital at El Sharqia, diagnosed with neck pain and active myofascial trigger points (MTrPs) in the upper fibres of trapezius muscle. Patients were divided randomly into two groups equal in number: group (A) received convential physical therapy (stretching exercise), group (B) received instrument assisted soft tissue mobilization (IASTM) and convential physical therapy. Methods: The Visual Analogue Scale (VAS) and Neck disability index scale (NDI) were assessed before the study and after four weeks. Results: The mean difference in VAS between groups post treatment was 1.6. There was a significant decrease in VAS of group B compared with that of group A post treatment. The mean difference in NDI between groups post treatment was 5.4%. There was a significant decrease in the NDI of group B compared with that of group A post treatment. Conclusion: soft tissue mobilization can be used on the treatment of cervical pain in nursing women. It has significant effect on Visual Analogue Scale and Neck disability index scale rather than convential physical therapy only

Cultural and social influences on Saudi family travel decisions: A systematic-quantitative synthesis for enhancing domestic tourism competitiveness in the face of international tourism

This research analyzes the cultural and sociological elements affecting Saudi family travel choices (FTD) and their implications for domestic tourist competitiveness (DTC) amid global competition. Employing a mixed-methods approach—combining a systematic literature review (SLR) with partial least squares structural equation modeling (PLS-SEM) on data from 469 Saudi respondents—the research reveals that cultural influences (β = 0.452) and social influences (β = 0.338) significantly drive FTD, which in turn enhances DTC (β = 0.427). Direct impacts of cultural (β = 0.208) and social elements (β = 0.213) on DTC were also significant, whereas foreign tourism allure adversely moderates the FTD-DTC link (β = -0.106). The research correlates with Saudi Arabia’s Vision 2030 and Sustainable Development Goals (SDGs), notably SDG 8 (economic development), SDG 11 (sustainable communities), SDG 12 (responsible consumerism), and SDG 5 (women equality). Practical options include using Halal tourism, AI-driven marketing, and gender-inclusive regulations to boost local competitiveness while protecting cultural identity

The role of STARA competencies in driving AI adoption performance in tourism and hospitality: A systematic-quantitative synthesis of dual mediation analysis of self-efficacy and Techno-Eustress

This study investigates the dual mediation roles of AI self-efficacy and techno-eustress in the relationship between leaders’ STARA (Smart Technology, AI, Robotics, Algorithms) competencies and AI adoption performance in tourism and hospitality. Employing a mixed-methods approach, the research integrates a systematic literature review of 28 peer-reviewed articles with quantitative data from 401 employees in Saudi five-star hotels and tourism firms. The systematic literature review synthesizes conceptualizations of STARA competencies and psychological mediators, while partial least squares structural equation modeling (PLS-SEM) tests hypotheses derived from social cognitive and technostress theories. Results reveal that leaders’ STARA competencies significantly enhance AI adoption performance both directly (β = 0.176) and indirectly via self-efficacy (β = 0.143) and techno-eustress (β = 0.195). The dual mediation model explains 39.3% of AI adoption variance, underscoring the interplay of technical leadership and psychological readiness. The results align with Sustainable Development Goals (SDGs) 8, 9, and 12, linking AI integration to decent work, innovation, sustainable practices, and future economics. The study advances digital leadership theory by integrating psychological mediators into technology adoption frameworks and offers actionable insights for cultivating AI-ready workforces through competency development and stress management

Chimeric vip3Aa16TC Gene Encoding the Toxic Core of the Vegetative Insecticidal Protein Enhanced Bacillus thuringiensis Entomopathogenicity

Vip3 insecticidal protein is produced by Bacillus thuringiensis during the vegetative stage. Its proteolysis by the midgut juice of susceptible larvae formed four major products of approximately 66, 45, 33 and 22 kDa. In this study, we cloned the vip3Aa16TC DNA encoding the “Vip3Aa16 toxic core (TC)” of 33 kDa corresponding to the Vip3Aa16 region from amino acid 200 to 456. The vip3Aa16TC chimeric gene carried by the pHT-vip3Aa16TC plasmid was under the control of the sporulation dependent promoters (BtI-BtII) and the Shine Dalgarno sequence of cry1Ac gene as well as the cry1Ia gene terminator. Western-blot analysis of the culture supernatants of the recombinant B. thuringiensis strain detected Vip3Aa16TC after growing for 14 to 56 h proving that this protein can be produced without the Vip3 amino- and carboxy-terminal regions. Interestingly, the preservation of the Vip3Aa16TC toxicity against the polyphagous lepidopteran Spodoptera littoralis makes it a promising polypeptide for the pest biological control

Effect of Dash Diet and Progressive Muscle Relaxation on Cardiovascular Risks in Postmenopausal Women

Introduction: Hypertension is prevalent in postmenopausal women; therefore, lifestyle changes can help to manage cardiovascular diseases (CVDs).Material and Methods: Ninety hypertensive postmenopausal women aged between 50 and 60 years, with a BMI varying from 30 to 35 kg/m2, were split randomly into three equal groups (n = 30 for each group). Group (A) was treated with a DASH diet weekly and antihypertensive medication (angiotensin-converting enzyme inhibitor (ACEI)), 1 tablet daily; group (B) was treated with progressive muscle relaxation (PMR), 3 times/week plus ACEI; and group (C) was treated with DASH diet weekly, PMR, 3 times/week plus ACEI. The treatment lasted for 3 months. Blood pressure was measured utilizing a sphygmomanometer, lipid profile was evaluated using blood testing, and stress level was evaluated utilizing the Perceived Stress Scale (PSS) before and after therapy.Results: There was a significant lowering in systolic (SBP) and diastolic (DBP) blood pressure (p < 0.05), PSS, significant improvement in lipid profile across groups following therapy in favor of group C (p < 0.01). There was no significant change across groups A and B in SBP and DBP (p > 0.05). There was a significantly improvement in lipid profile in group A compared to that in group B after therapy (p < 0.05). There was a significantly reduction in PSS in group B compared to that in group A after therapy (p < 0.01).Conclusion: The DASH diet and PMR were effective in reducing cardiovascular risks in postmenopausal women