Visual privacy as an approach to improve human needs in residential buildings in Egypt

Architecture reflects a nation’s cultural, social, and environmental characteristics. As a result of the recent globalization, countries have lost their distinctive architectural identities; due to this, it is difficult to identify A country’s unique identity locally and regionally. Specifically, in Egypt, houses in the traditional style are considered one of the most iconic architectural styles. There is an amazing local identity and a unique spatial quality in the region that characterizes Egypt. On the other hand, Western influences have caused many of the values and attributes of houses to fade. One of the most prominent values is the home’s loss of visual privacy. Architectural openings were limited to ventilation and lighting only, without considering privacy and meeting the human needs of that society. Therefore, the research paper aims to extract a method for designing treatments to regain the visual privacy of residential homes in Egypt. Depending on the architectural elements of traditional houses in Egypt that helped achieve privacy in the past, such as the Mashrabiya. The research presented several experiments with sequential steps for different perforation percentages (PP) for a perforated screen in front of the room window, coinciding with the study of the mechanism of vision of the human eye and the extent of its accuracy in seeing objects and its field of vision, to determine the maximum perforation percentage that maintains visual privacy. The experiment was conducted on the street with a width of 6m the most common width in Egypt. The research paper found that a PP of 1% to 5% for perforated screens achieves privacy for private and intimate rooms. In comparison, a PP of 10% to 15% is suitable for semi-private places such as reception and living rooms, and finally, a PP of 20% to 25% is suitable for semi-public places such as gardens overlooking the outside. 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Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem cell rolling.

Hematopoietic stem/progenitor cell (HSPC) homing occurs via cell adhesion mediated by spatiotemporally organized ligand-receptor interactions. Although molecules and biological processes involved in this multistep cellular interaction with endothelium have been studied extensively, molecular mechanisms of this process, in particular the nanoscale spatiotemporal behavior of ligand-receptor interactions and their role in the cellular interaction, remain elusive. We introduce a microfluidics-based super-resolution fluorescence imaging platform and apply the method to investigate the initial essential step in the homing, tethering, and rolling of HSPCs under external shear stress that is mediated by selectins, expressed on endothelium, with selectin ligands (that is, CD44) expressed on HSPCs. Our new method reveals transient nanoscale reorganization of CD44 clusters during cell rolling on E-selectin. We demonstrate that this mechanical force-induced reorganization is accompanied by a large structural reorganization of actin cytoskeleton. The CD44 clusters were partly disrupted by disrupting lipid rafts. The spatial reorganization of CD44 and actin cytoskeleton was not observed for the lipid raft-disrupted cells, demonstrating the essential role of the spatial clustering of CD44 on its reorganization during cell rolling. The lipid raft disruption causes faster and unstable cell rolling on E-selectin compared with the intact cells. Together, our results demonstrate that the spatial reorganization of CD44 and actin cytoskeleton is the result of concerted effect of E-selectin-ligand interactions, external shear stress, and spatial clustering of the selectin ligands, and has significant effect on the tethering/rolling step in HSPC homing. Our new experimental platform provides a foundation for characterizing complicated HSPC homing

One Parameter Composite Semigroups of Linear Bounded Operators in Strong Operator Topology of Schatten Class Cp

For semigroups of linear bounded operators on Hilbert spaces, the problem of being in Cp , 0 Keyword

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020