Long-time relaxation in pilot-wave theory

We initiate the study of relaxation to quantum equilibrium over long timescales in pilot-wave theory. We simulate the time evolution of the coarse-grained H-function Hbar(t) for a two-dimensional harmonic oscillator. For a (periodic) wave function that is a superposition of the first 25 energy states we confirm an approximately exponential decay of Hbar over five periods. For a superposition of only the first four energy states we are able to calculate Hbar(t) over 50 periods. We find that, depending on the set of phases in the initial wave function, Hbar can decay to a large nonequilibrium residue exceeding 10% of its initial value or it can become indistinguishable from zero (the equilibrium value). We show that a large residue in Hbar is caused by a tendency for the trajectories to be confined to sub-regions of configuration space for some wave functions, and that this is less likely to occur for larger numbers of energy states (if the initial phases are chosen randomly). Possible cosmological implications are briefly discussed.Comment: 23 pages, 11 figures. Significant improvements in v2; new section on confinement of trajectories. Accepted by J. Phys. A: Math. Theo

A Rigorous Derivation of Electromagnetic Self-force

During the past century, there has been considerable discussion and analysis of the motion of a point charge, taking into account "self-force" effects due to the particle's own electromagnetic field. We analyze the issue of "particle motion" in classical electromagnetism in a rigorous and systematic way by considering a one-parameter family of solutions to the coupled Maxwell and matter equations corresponding to having a body whose charge-current density $J^a(\lambda)$ and stress-energy tensor $T_{ab} (\lambda)$ scale to zero size in an asymptotically self-similar manner about a worldline $\gamma$ as $\lambda \to 0$. In this limit, the charge, $q$, and total mass, $m$, of the body go to zero, and $q/m$ goes to a well defined limit. The Maxwell field $F_{ab}(\lambda)$ is assumed to be the retarded solution associated with $J^a(\lambda)$ plus a homogeneous solution (the "external field") that varies smoothly with $\lambda$. We prove that the worldline $\gamma$ must be a solution to the Lorentz force equations of motion in the external field $F_{ab}(\lambda=0)$. We then obtain self-force, dipole forces, and spin force as first order perturbative corrections to the center of mass motion of the body. We believe that this is the first rigorous derivation of the complete first order correction to Lorentz force motion. We also address the issue of obtaining a self-consistent perturbative equation of motion associated with our perturbative result, and argue that the self-force equations of motion that have previously been written down in conjunction with the "reduction of order" procedure should provide accurate equations of motion for a sufficiently small charged body with negligible dipole moments and spin. There is no corresponding justification for the non-reduced-order equations.Comment: 52 pages, minor correction

DETECTING CHANGING POLARIZATION STRUCTURES IN SAGITTARIUS A* WITH HIGH FREQUENCY VLBI

Sagittarius A* is the source of near infrared, X-ray, radio, and (sub)millimeter emission associated with the supermassive black hole at the Galactic Center. In the submillimeter regime, Sgr A* exhibits time-variable linear polarization on timescales corresponding to <10 Schwarzschild radii of the presumed 4 × 10[superscript 6] M[subscript ☉] black hole. In previous work, we demonstrated the potential for total-intensity (sub)millimeter-wavelength very long baseline interferometry (VLBI) to detect time-variable—and periodic—source structure changes in the Sgr A* black hole system using nonimaging analyses. Here, we extend this work to include full polarimetric VLBI observations. We simulate full-polarization (sub)millimeter VLBI data of Sgr A* using a hot spot model that is embedded within an accretion disk, with emphasis on nonimaging polarimetric data products that are robust against calibration errors. Although the source-integrated linear polarization fraction in the models is typically only a few percent, the linear polarization fraction on small angular scales can be much higher, enabling the detection of changes in the polarimetric structure of Sgr A* on a wide variety of baselines. The shortest baselines track the source-integrated linear polarization fraction, while longer baselines are sensitive to polarization substructures that are beam-diluted by connected-element interferometry. The detection of periodic variability in source polarization should not be significantly affected even if instrumental polarization terms cannot be calibrated out. As more antennas are included in the (sub)millimeter-VLBI array, observations with full polarization will provide important new diagnostics to help disentangle intrinsic source polarization from Faraday rotation effects in the accretion and outflow region close to the black hole event horizon.National Science Foundation (U.S.

Knowledge and Perceptions about Clinical Trials and the Use of Biomedical Samples: Findings from a Qualitative Study in Rural Northern Ghana.

INTRODUCTION: Clinical trials conducted in sub-Saharan Africa have helped to address the prevalent health challenges. The knowledge about how communities perceive clinical trials is however only now evolving. This study was conducted among parents whose children participated in past clinical trials in northern Ghana to assess their knowledge and perceptions of clinical trials and the use of biomedical samples. METHOD: This was a qualitative study based on eighty in-depth interviews with parents. The participants were randomly selected from among parents whose children were enrolled in a clinical trial conducted in the Kassena-Nankana districts between 2000 and 2003. The interviews were transcribed and coded into emergent themes using Nvivo 9 software. The thematic analysis framework was used to analyze the data. RESULTS: Study participants reported that clinical trials were carried out to determine the efficacy of drugs and to make sure that these drugs were suitable for human beings to use. The conduct of clinical trials was perceived to have helped to reduce the occurrence of diseases such as malaria, cerebrospinal meningitis and diarrhea. Quality of care was reported to be better in clinical trials than in the routine care. Parents indicated that participation in clinical trials positively influenced their health-seeking behavior. Apprehensions about blood draw and the use to which samples were put were expressed, with suspicion by a few participants that researchers sold blood samples. The issue of blood draw was most contentious. CONCLUSION: Parents perception about the conduct of clinical trials in the study districts is generally positive. However, misconceptions made about the use of blood samples in this study must be taken seriously and strategies found to improve transparency and greater community acceptability

The Sine Gordon Model: Perturbation Theory and Cluster Monte Carlo

We study the expansion of the surface thickness in the 2-dimensional lattice Sine Gordon model in powers of the fugacity z. Using the expansion to order z**2, we derive lines of constant physics in the rough phase. We describe and test a VMR cluster algorithm for the Monte Carlo simulation of the model. The algorithm shows nearly no critical slowing down. We apply the algorithm in a comparison of our perturbative results with Monte Carlo data.Comment: compressed and uuencoded PostScript file, 25 pages, preprints CERN TH.7374/94, MS-TPI-94-

Factors influencing willingness to participate in new drug trial studies: a study among parents whose children were recruited into these trials in northern Ghana.

BACKGROUND: During the last decade, the number of clinical trials conducted in sub-Saharan Africa has increased significantly which has helped to address priority health problems in the region. Navrongo health research centre since it was established in 1989, has conducted several trial studies including rectal artesunate trial in the Kassena-Nankana districts. However, there is little evidence-based for assessing the impact of new drug trials. This study explored factors that motivate parents to allow their children to participate in new drug trials in northern Ghana. METHOD: The study used both quantitative and qualitative methods. The participants were randomly selected from among parents whose children were enrolled in a new drug trial conducted in the Kassena-Nankana districts between 2000 and 2003. QSR Nvivo 9 software was used to code the qualitative data into themes before analysis while STATA software Version 11.2© was used to analyze the quantitative data. RESULTS: The results showed that majority (95.9%) of the parents were willing to allow their children to be enrolled in future new drug trials. The main factors motivating their willingness to allow their children to be enrolled in these trials were quality of health care services offered to trial participants (92.9%), detail medical examination (90.8%), promptness of care provided (94.4%) and quality of drugs (91.9%). Other factors mentioned included disease prevention (99.5%) and improved living standard (96.1%). Parents reported that the conduct of these trials had reduced the frequency of disease occurrences in the communities because of the quality of health care services provided to the children recruited into these trial studies. CONCLUSION: Though the implementation of clinical trials in the study area is believed to have positive impact on health status of people particularly trial participants, measures should however be taken to address safety and likely side effects of new drugs given to trial participants during these trial studies

Testing General Relativity with Accretion-Flow Imaging of SgrA*

The Event Horizon Telescope is a global, very long baseline interferometer capable of probing potential deviations from the Kerr metric, which is believed to provide the unique description of astrophysical black holes. Here, we report an updated constraint on the quadrupolar deviation of Sagittarius A∗ within the context of a radiatively inefficient accretion flow model in a quasi-Kerr background. We also simulate near-future constraints obtainable by the forthcoming eight-station array and show that in this model already a one-day observation can measure the spin magnitude to within 0.005, the inclination to within 0.09°, the position angle to within 0.04°, and the quadrupolar deviation to within 0.005 at 3σ confidence. Thus, we are entering an era of high-precision strong gravity measurements

Variation of water quality across Cooum river in Chennai city

The huge demand for freshwater resources in the 21st century can be attributed to population growth, advanced agricultural practices and industrial usages. This study attempts to evaluate the water quality of Cooum river across Chennai, and was carried out by systematic collection and analysis of 5 water samples from 5 regions. Samples collected at some parts of the city were even found to be not fit for irrigation as they had high acidity, low dissolved oxygen and high amount of dissolved solids. Some samples were also found to have certain microbes which pose health hazards when ingested. The major contaminant sources identified in the areas were the samples were polluted were liquid and solid wastes, discharges from factories and refineries, drainage of sewage, and brine water in estuaries. Keywords: Cooum river, Water quality, Hydrochemistry, Aquatic microbiology, River managemen

The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study.

BACKGROUND:Septic cardiomyopathy (SCM) is common in sepsis and associated with increased morbidity and mortality. Left ventricular global longitudinal strain (LV GLS), measured by speckle tracking echocardiography, allows improved identification of impaired cardiac contractility. The peripheral blood transcriptome may be an important window into SCM pathophysiology. We therefore studied the peripheral blood transcriptome and LV GLS in a prospective cohort of patients with sepsis. RESULTS:In this single-center observational pilot study, we enrolled adult patients (age &gt; 18) with sepsis within 48 h of admission to the ICU. SCM was defined as LV GLS &gt; - 17% based on echocardiograms performed within 72 h of admission. We enrolled 27 patients, 24 of whom had high-quality RNA results; 18 (75%) of 24 had SCM. The group was 50% female and had a median (IQR) age of 59.5 (48.5-67.0) years and admission APACHE II score of 21.0 (16.0-32.3). Forty-six percent had septic shock. After filtering for low-expression and non-coding genes, 15,418 protein coding genes were expressed and 73 had significantly different expression between patients with vs. without SCM. In patients with SCM, 43 genes were upregulated and 30 were downregulated. Pathway analysis identified enrichment in type 1 interferon signaling (adjusted p &lt; 10-5). CONCLUSIONS:In this hypothesis-generating study, SCM was associated with upregulation of genes in the type 1 interferon signaling pathway. Interferons are cytokines that stimulate the innate and adaptive immune response and are implicated in the early proinflammatory and delayed immunosuppression phases of sepsis. While type 1 interferons have not been implicated previously in SCM, interferon therapy (for viral hepatitis and Kaposi sarcoma) has been associated with reversible cardiomyopathy, perhaps suggesting a role for interferon signaling in SCM