Synthesis of process related impurities of Citicoline and Citicoline sodium

304-314Citicoline is the diphosphate ester of cytidine. The said compound is sensitive to chemical atmosphere and exhibits formation of process/degradation impurities. Herein is reported a comprehensive synthesis of the pharmacopeia impurities of Citicoline and Citicoline sodium with an objective to provide impurities for better understanding and control in the Citicoline preparation process. This report provides synthetic methodologies for the impurities, considering ease of handling, chemistry and eliminating tedious purification. All the impurities are characterized and the structures confirmed

Process Development of Citalopram/Escitalopram Oxalate: Isolation and Synthesis of Novel Impurities

During process optimization of Escitalopram oxalate novel impurities, <b>6</b> and <b>7</b> were observed, which were isolated and characterized, and the proposed structure was confirmed by chemical synthesis. Investigation of the cause of impurities formation improved the yield and purity of the drug product during the bulk API synthesis