Research Paper A Convenient One-Pot Synthesis of 2-Amino-4-Phenyl-1,8-Naphthyridine-3-Carbonitrile Derivatives

Abstract: A simple, efficient and one-pot procedure has been described for the synthesis of 2-amino-4-phenyl-1,8-naphthyridine-3-carbonitrile derivatives. A mixture of 2-amino pyridine, malononitrile and aromatic aldehydes were reacted in presence of catalytic amount of 3-nitrophenylboronic acid as catalyst at room temperature to produce 2-amino-4-phenyl-1,8-naphthyridine-3-carbonitriles. The mild reaction condition, short reaction time, high yield and simple experimental operation are the salient future of this method