Vetores de expansão urbana em Aracaju-SE, Brasil: produção (entrelaçada) de cidade pelo Estado e mercado imobiliário

Esta pesquisa tem como objetivo analisar a produção habitacional oriunda atuação do mercado imobiliário e do Estado e apontar os vetores de expansão urbana em Aracaju-SE, Brasil, entre 2000 a 2014. A capital de Sergipe apresentou dinamismo na produção do espaço a partir da atuação do mercado, de forma mais intensa, a partir da promulgação do Plano Diretor, em 2000, mediante apoio do Estado, através de legislações permissivas, ampliação da infraestrutura viária e incentivo ao crédito imobiliário. Verificou-se um expressivo aumento do número de empreendimentos imobiliários, resultando no adensamento de bairros urbanizados e valorizados, e, por outro lado, a expansão fragmentada e periférica em áreas sem infraestrutura. Para o desenvolvimento deste, foi realizado levantamento bibliográfico, coleta de dados nos órgãos públicos, organizados sob a forma de tabelas e cartografias, que permitiu quantificar e espacializar a dinâmica urbana em Aracaju.This research aims to analyze the housing production from the real estate market and the State and to point out the vectors of urban expansion in Aracaju-SE, Brazil, between 2000 and 2014. The capital of Sergipe presented dynamism in the production of space from the performance of the market, more intensely, after the promulgation of the Master Plan in 2000, through State support, through permissive legislation, expansion of road infrastructure and encouragement of real estate credit. There was a significant increase in the number of real estate developments, resulting in the densification of urbanized and valued neighborhoods, and, on the other hand, the fragmented and peripheral expansion in areas without infrastructure. For the development of this, a bibliographic survey was carried out, data collection in public agencies, organized in the form of tables and cartographies, which allowed quantify and spatialize the urban dynamics in Aracaj

Comment développer une pédagogie 3.0

Comprend des références bibliographiquesLe métier d’enseignant évolue, notamment grâce au développement des outils numériques. Les institutions d’enseignement se doivent d’être vigilantes et de procéder au développement professionnel de leurs formateurs. La contribution présente ici un exemple de dispositif d’accompagnement des enseignants d’une grande école de gestion française afin d’introduire le numérique dans leurs pratiques pédagogiques. Le dispositif détaillé, le SmartLab, comporte quatre dimensions dont deux seront présentées : les « Cafés pédagogiques » et les « Ateliers Smarty ». Un retour d’expériences sera ensuite réalisé via une enquête de satisfaction et un recueil de témoignages pour conclure sur les apports d’un tel dispositif, ses conditions de mise en oeuvre et le contexte favorable nécessaire à ce type d’approche qui permet l’émergence d’un nouveau type de comportement chez les enseignants : "l’intraprenance"

Interaction between Staphylococcus aureus and Pseudomonas aeruginosa is beneficial for colonisation and pathogenicity in a mixed-biofilm

Debate regarding the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa in wounds remains contentious, with the dominant hypothesis describing a situation akin to niche partitioning, whereby both microorganisms are present but occupy distinct regions of the wound without interacting. In contrast, we hypothesised that these microorganisms do interact during early co-colonisation in a manner beneficial to both bacteria. We assessed competitive interaction between S. aureus and P. aeruginosa in biofilm cultured for 24-72 h and bacterial aggregates analogous to those observed in early (<24h) biofilm formation, and interaction with human keratinocytes. We observed that S. aureus predominated in biofilm and non-attached bacterial aggregates, acting as a pioneer for the attachment of P. aeruginosa. We report for the first time that S. aureus mediates a significant (P<0.05) increase in the attachment of P. aeruginosa to human keratinocytes, and that P. aeruginosa promotes an invasive phenotype in S. aureus. We show that co-infected keratinocytes exhibit an intermediate inflammatory response concurrent with impaired wound closure that is in keeping with a sustained pro-inflammatory response which allows for persistent microbial colonisation. These studies demonstrate that, contrary to the dominant hypothesis, interactions between S. aureus and P. aeruginosa may be an important factor for both colonisation and pathogenicity in the chronic infected wound

Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions

This work was supported in part by the European Union, Area NMP.2013.1.1–2: Self-assembly of naturally occurring nanosystems: CellulosomePlus Project number: 604530, and by the EU Seventh Framework Programme (FP7 2007–2013) under the WallTraC project (Grant Agreement no 263916), and BioStruct-X (grant agreement no 283570). This paper reflects the author’s views only. The European Community is not liable for any use that may be made of the information contained herein. CMGAF is also supported by Fundação para a Ciência e a Tecnologia (Lisbon, Portugal) through grants PTDC/BIA-PRO/103980/2008 and EXPL/BIA-MIC/1176/2012. EAB is also funded by a grant (No. 1349/13) from the Israel Science Foundation (ISF), Jerusalem, Israel and by a grant (No. 2013284) from the U.S.-Israel Binational Science Foundation (BSF). E.A.B. is the incumbent of The Maynard I. and Elaine Wishner Chair of Bio-organic Chemistry.Peer reviewedPublisher PD

Prevalence of and Factors Associated with Negative Microscopic Diagnosis of Cutaneous Leishmaniasis in Rural Peru.

Cutaneous leishmaniasis is endemic to South America where diagnosis is most commonly conducted via microscopy. Patients with suspected leishmaniasis were referred for enrollment by the Ministry of Health (MoH) in Lima, Iquitos, Puerto Maldonado, and several rural areas of Peru. A 43-question survey requesting age, gender, occupation, characterization of the lesion(s), history of leishmaniasis, and insect-deterrent behaviors was administered. Polymerase chain reaction (PCR) was conducted on lesion materials at the Naval Medical Research Unit No. 6 in Lima, and the results were compared with those obtained by the MoH using microscopy. Factors associated with negative microscopy and positive PCR results were identified using

Concepções sobre a comunicação matemática de uma futura professora

Este texto apresenta um estudo de caso, de natureza interpretativa, focado nas concepções de comunicação matemática de uma futura professora, que está a iniciar um curso de Educação Básica (1.º ciclo de estudos, que dá acesso aos segundos ciclos de formação de professores – 1.º e 2.º ciclos do ensino básico – e educação de infância). O estudo foi orientado por dois objectivos: (i) conhecer as concepções de uma futura professora sobre a comunicação matemática e o papel que esta desempenha na aprendizagem e no ensino da disciplina; (ii) compreender como evoluem essas concepções sobre a comunicação matemática e qual o papel da formação inicial nesse processo de desenvolvimento. Os dados recolhidos, através de inquérito por entrevista, mostram que a jovem futura professora defende um modo de comunicação reflexiva na aprendizagem da disciplina, que, embora consonante com o seu estilo pessoal, contrasta com a sua experiência de aluna no ensino secundário. A experiência no ensino superior, embora ainda no princípio, revela já a sua influência na forma como concebe o papel da linguagem matemática na comunicação e no valor da discussão na aprendizagem

Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.

Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 and CD68 co-expression. Despite the distinct findings, accurate diagnosis of fibrolamellar carcinoma continues to be a challenge. Recently, fibrolamellar carcinomas were found to harbor a characteristic somatic gene fusion, DNAJB1-PRKACA. A break-apart fluorescence in situ hybridization (FISH) assay was designed to detect this fusion event and to examine its diagnostic performance in a large, multicenter, multinational study. Cases initially classified as fibrolamellar carcinoma based on histological features were reviewed from 124 patients. Upon central review, 104 of the 124 cases were classified histologically as typical of fibrolamellar carcinoma, 12 cases as 'possible fibrolamellar carcinoma' and 8 cases as 'unlikely to be fibrolamellar carcinoma'. PRKACA FISH was positive for rearrangement in 102 of 103 (99%) typical fibrolamellar carcinomas, 9 of 12 'possible fibrolamellar carcinomas' and 0 of 8 cases 'unlikely to be fibrolamellar carcinomas'. Within the morphologically typical group of fibrolamellar carcinomas, two tumors with unusual FISH patterns were also identified. Both cases had the fusion gene DNAJB1-PRKACA, but one also had amplification of the fusion gene and one had heterozygous deletion of the normal PRKACA locus. In addition, 88 conventional hepatocellular carcinomas were evaluated with PRKACA FISH and all were negative. These findings demonstrate that FISH for the PRKACA rearrangement is a clinically useful tool to confirm the diagnosis of fibrolamellar carcinoma, with high sensitivity and specificity. A diagnosis of fibrolamellar carcinoma is more accurate when based on morphology plus confirmatory testing than when based on morphology alone

Phylogeny, ultrastructure, histopathology and prevalence of Myxobolus oliveirai sp. nov., a parasite of Brycon hilarii (Characidae) in the Pantanal wetland, Brazil

This paper presents the morphological, histological and ultrastructural characteristics of Myxobolus oliveirai sp. nov., a parasite of the gill filaments in Brycon hilarii from the Brazilian Pantanal. Out of 216 B. hilariispecimens examined (126 wild and 90 cultivated), 38.1% of wild specimens (n = 48) were infected. The parasites form elongated plasmodia primarily in the tip of gill filaments, reaching about 3 mm in length. A thorough comparison with all the Myxobolus species described from South American hosts, as well as nearly all the Myxobolus species described so far is provided. Partial sequencing of the 18S rDNA gene revealed a total of 1,527 bp. The Myxobolus species parasite of B. hilarii did not match any of the Myxozoa available in GenBank. In the phylogenetic analysis, M. oliveirai sp. nov. composed a monophyletic group with eight other species: five species of Myxobolus parasites of mugilid fishes, two parasites of pangasiid and one of centrarchid. Infection prevalence values of the parasite revealed no significant differences between wet and dry seasons or between males and females. The importance of the infection to the farming of the host species is emphasized.FAPESPCEPTA - ICMBioCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES