Gender inequalities and depression

More gender-equal societies promote better mental health among both men and women and reduce the gender gap in depressive symptom

Age differences in mammography screening reconsidered: life course trajectories in 13 European countries

Background: Breast cancer is the most common cause of cancer mortality among European women. To reduce mortality risk, early detection through mammography screening is recommended from the age of 50 years onwards. Although timely initiation is crucial for cancer prognosis, the temporal dimension has largely been ignored in research. In cross-sectional research designs, it is not clear whether reported age differences reflect ‘true’ age effects and/or presumed period effects resulting from evolving knowledge and screening programmes. Methods: We use longitudinal data from the survey of Health, Ageing and Retirement (SHARELIFE, 2008), which enables to cast light on age differences by providing retrospective information on the age at which women commenced regular mammography screening. Moreover, the cross-national dimension of the SHARE permits framing the results within the context of nationally implemented screening programmes. By means of the Kaplan–Meier procedure, we examine age trajectories for five 10-year birth cohorts in 13 European countries (n = 13 324). Results: Birth cohorts show very similar age trajectories for each country. Along with the observation that large country differences and country-specific deviations coincide with screening programme characteristics, this suggests strong period effects related to implemented national screening programmes. Conclusion: Age differences in mammography screening generally reflect the period effects of national screening policies. This leaves little room for economic theories about human health capital that leave out the institutional context of preventive health care provision

Divorce and the multidimensionality of men and women's mental health: the role of social-relational and socio-economic conditions

Research consistently reveals that the divorced generally face more mental health problems than the married. Less attention however has been paid to positive mental health indicators. Insight in these however may help policy makers and care providers to see both the broader picture and stimulate active coping. Using data from the European Social Survey (2006–2007), differences in both feelings of depression, and in feelings of self-esteem, autonomy, and competence between the married (N = 14,072) and divorced (N = 4,304) are estimated for women and men separately. Drawing on stress and coping theories, we map how specific social-relational and socio-economic conditions relate. Analyses reveal that divorce is related not only to more feelings of depression, but also to lower levels of self-esteem and competence. Difference scores in mental health based on marital status are also found to differ significantly between men and women for competence, with the difference being more pronounced in men. Additionally, social-relational and socio-economic conditions explain much of the gap in depression scores – and to a lesser extent, in self-esteem and competence scores – between the married and divorced. Finally, some interesting gender differences were found in how social-relational and socio-economic conditions relate to mental health when divorced, with women especially seeming to benefit from advantageous socio-economic conditions

Heterologous screening of hybridomas for the development of broad-specific monoclonal antibodies against deoxynivalenol and its analogues

Hapten heterology was introduced into the steps of hybridoma selection for the development of monoclonal antibodies (MAbs) against deoxynivalenol (DON). Firstly, a novel heterologous DON hapten was synthesised and covalently coupled to proteins (i.e. bovine serum albumin (BSA), ovalbumin and horseradish peroxidase) using the linkage of cyanuric chloride (CC). After immunisation, antisera from different DON immunogens were checked for the presence of useful antibodies. Next, both homologous and heterologous enzyme-linked immunosorbent assays were conducted to screen for hybridomas. It was found that heterologous screening could significantly reduce the proportion of false positives and appeared to be an efficient approach for selecting hybridomas of interest. This strategy resulted in two kinds of broad-selective MAbs against DON and its analogues. They were quite distinct from other reported DON-antibodies in their cross-reactivity profiles. A unique MAb 13H1 derived from DON-CC-BSA immunogen could recognise DON and its analogues in the order of HT-2 toxin > 15-acetyl-DON > DON > nivalenol, with IC50 ranging from 1.14 to 7.69 mu g/ml. Another preferable MAb 10H10 generated from DON-BSA immunogen manifested relatively similar affinity to DON, 3-acetyl-DON and 15-acetyl-DON, with IC50 values of 22, 15 and 34 ng/ml, respectively. This is the first broad-specific MAb against DON and its two acetylated forms and thus it can be used for simultaneous detection of the three mycotoxins

In the land of pharma : a qualitative analysis of the reputational discourse of the pharmaceutical industry

The pharmaceutical industry has been battling a negative reputation and has been confronted with accusations such as putting profits before patients and manipulating clinical trial results. In this study, we focus on how pharmaceutical companies address what we define as the Bad Pharma discourse. Drawing on interviews, press releases, corporate documentation and ethnographic fieldwork, we analyse the main themes that are used by the Belgian pharmaceutical industry to construct its reputational discourse, and we focus on how this discourse is shaped by the Bad Pharma discourse. Our results illustrate that on the one hand, the industry contests the Bad Pharma discourse by generating an alternative discourse. On the other hand, they also partly embrace and reframe this Bad Pharma discourse. This way, current societal debates are entextualised in the reputational discourses of the pharmaceutical industry

Nostalgia's Violence

This essay considers some of the ways in which nostalgia figures in contemporary social theory as well as addresses the post/modern character of nostalgia. It does so with the aim of exploring the question of colonial and imperial violence at the heart of nostalgia