Host redshifts from gravitational-wave observations of binary neutron star mergers

Inspiralling compact binaries as standard sirens will soon become an invaluable tool for cosmology when advanced interferometric gravitational-wave detectors begin their observations in the coming years. However, a degeneracy in the information carried by gravitational waves between the total rest-frame mass $M$ and the redshift $z$ of the source implies that neither can be directly extracted from the signal, but only the combination $M(1+z)$, the redshifted mass. Recent work has shown that for binary neutron star systems, a tidal correction to the gravitational-wave phase in the late-inspiral signal that depends on the rest-frame source mass could be used to break the mass-redshift degeneracy. We propose here to use the signature encoded in the post-merger signal to deduce the redshift to the source. This will allow an accurate extraction of the intrinsic rest-frame mass of the source, in turn permitting the determination of source redshift and luminosity distance solely from gravitational-wave observations. This will herald a new era in precision cosmography and astrophysics. Using numerical simulations of binary neutron star mergers of very slightly different mass, we model gravitational-wave signals at different redshifts and use Bayesian parameter estimation to determine the accuracy with which the redshift can be extracted for a source of known mass. We find that the Einstein Telescope can determine the source redshift to $sim 10$--$20$ at redshifts of $z<0.04$.Comment: 10 pages, 4 figures; same as the version before except for acknowledgment

What works for knowledge brokers? Assessing the communication challenge of linking research to policy.

Across universities and other research institutions, knowledge brokers play an important role in linking researchers to potential users of their research. Reporting on a recent survey, Sandra Messenger and Sarah Foxen highlight the challenges that knowledge brokers face and how, as a community of experts, open conversations on communication strategies may help stimulate personal reflection and input into individual and collective approaches to widening researcher awareness of policy engagement opportunities

Identification and characterisation of mutations associated with von Willebrand disease in a Turkish patient cohort

Several cohort studies have investigated the molecular basis of von Willebrand disease (VWD); however, these have mostly focused on European and North American populations. This study aimed to investigate mutation spectrum in 26 index cases (IC) from Turkey diagnosed with all three VWD types, the majority (73%) with parents who were knowingly related. IC were screened for mutations using multiplex ligation-dependent probe amplification and analysis of all von Willebrand factor gene (VWF) exons and exon/intron boundaries. Selected missense mutations were expressed in vitro. Candidate VWF mutations were identified in 25 of 26 IC and included propeptide missense mutations in four IC (two resulting in type 1 and two in recessive 2A), all influencing VWF expression in vitro. Four missense mutations, a nonsense mutation and a small in-frame insertion resulting in type 2A were also identified. Of 15 type 3 VWD IC, 13 were homozygous and two compound heterozygous for 14 candidate mutations predicted to result in lack of expression and two propeptide missense changes. Identification of intronic breakpoints of an exon 17–18 deletion suggested that the mutation resulted from non-homologous end joining. This study provides further insight into the pathogenesis of VWD in a population with a high degree of consanguineous partnerships

Metagenomic domain substitution for the high-throughput creation of non-ribosomal peptide analogues

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Identifying and assessing effectiveness of alternative low-effort nitrogen footprint reductions in small research institutions

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Messenger, S., Lloret, J., Galloway, J. N., & Giblin, A. Identifying and assessing effectiveness of alternative low-effort nitrogen footprint reductions in small research institutions. Environmental Research Letters, 16(3), (2021): 035014, https://doi.org/10.1088/1748-9326/abd9f6.Concern over the ecological damage of excess nitrogen has brought increased attention to the role of research institutions and universities in contributing to this problem. Institutions often utilize the concept of the ecological 'footprint' to quantify and track nitrogen emissions resulting from their activities and guide plans and commitments to reduce emissions. Often, large-scale changes and commitments to reduce nitrogen footprints are not feasible at small institutions due to monetary and manpower constraints. We partnered with managers in the dining and facilities departments at the Marine Biological Laboratory (MBL), a small research institution in Woods Hole, Massachusetts, to develop five low-effort strategies to address nitrogen emissions at the institution using only resources currently available within those departments. Each proposed strategy achieved emissions reductions in their sector and in the overall nitrogen footprint of the MBL. If all modelled strategies are applied simultaneously, the MBL can achieve a 7.7% decrease in its nitrogen footprint. Managers at MBL considered strategies that required no monetary input most feasible. The intersection of carbon and nitrogen emissions also means the modelled strategies had the co-benefit of reducing the MBL's carbon footprint, strengthening the argument for applying these strategies. This paper may serve as a model for similar institutions looking to reduce the ecological impact of their activities.The work of the Nitrogen Footprint Tool Network was supported by Cooperative Agreement No. 83563201 awarded by the U.S. Environmental Protection Agency

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Managing surgical demand when needs outstrip resource:qualitative investigation of colorectal cancer surgery provision in the first wave of the COVID-19 pandemic

Abstract Background At the onset of the COVID-19 pandemic, elective surgical provision was severely affected by the need for hospital reorganization to care for critically ill patients. In response, National Health Service (NHS) England issued national guidance proposing acceptable time intervals for postponing different types of surgical procedure. This study reports healthcare professionals’ private accounts of the strategies adopted to manage the imbalance of demand and resource, using colorectal cancer surgery as a case study. Methods Twenty-seven semistructured interviews were conducted with healthcare professionals between June and November 2020. A key informant sampling approach was used, followed by snowballing to achieve maximum regional variation across the UK. Data were analysed thematically using the constant comparison approach. Results In the context of considerable resource constraint, surgical teams overcame challenges to continue elective cancer provision. They achieved this by pursuing a combination of strategies: relocating surgical services; prioritizing patients within and across surgical specialties; adapting patient treatment plans; and introducing changes to surgical team working practices. Despite national guidance, prioritization decisions were framed as complex, and the most challenging of the strategies to implement, both practically and emotionally. Conclusion There is a need to better support surgeons tasked with prioritizing patients when capacity exceeds demand. </jats:sec